2003
DOI: 10.1007/bf03190867
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Atrial natriuretic peptide contributes to the antihypertensive action of many drugs

Abstract: Data derived from a 10 years research program of our team demonstrate that many categories of antihypertensive drugs like beta-adrenergic blockers, alpha1-adrenergic blockers, ACE inhibitors, AT1-receptor antagonists and calcium-entry blockers increase plasma atrial natriuretic peptide (ANP) levels after a medium-term treatment of patients suffering from moderate essential hypertension. ANP always increases despite the drop of the arterial pressure and the fact that the left atrial and ventricular diameters re… Show more

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Cited by 5 publications
(2 citation statements)
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“…This is a very important finding because the relation between the plasma levels of ANP and the systolic blood pressure rate reflects mechanisms of the antihypertensive action of the drug after a medium term treatment. Nebivolol follows the same rule as~ adrenergic blockers of older generation as well as antihypertensive drugs of other classes (3)(4)(5)(6)(8)(9)(10)(11)(12)(13)(14)(15).…”
Section: Discussionmentioning
confidence: 99%
“…This is a very important finding because the relation between the plasma levels of ANP and the systolic blood pressure rate reflects mechanisms of the antihypertensive action of the drug after a medium term treatment. Nebivolol follows the same rule as~ adrenergic blockers of older generation as well as antihypertensive drugs of other classes (3)(4)(5)(6)(8)(9)(10)(11)(12)(13)(14)(15).…”
Section: Discussionmentioning
confidence: 99%
“…According to the investigation, ANP seems to be an important mediator between the p-adrenergic blockers and the therapy of arterial hypertension. Since then, interest has been expanded to investigate other antihypertensive agents and their linkage to ANP and the results of such investigation have been confirmative (1)(2)(3)(4).…”
mentioning
confidence: 99%