Atrial Natriuretic Peptide Attracts Human Spermatozoa in Vitro

Zamir, Nadav; Riven-Kreitman, Rivka; Manor, Mira; Makler, Amnon; Blumberg, Shmaryahu; Ralt, Dina; Eisenbach, Michael

doi:10.1006/bbrc.1993.2449

Cited by 47 publications

(37 citation statements)

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“…Upon ANP and NPR1 binding, ANP activates the cyclic GMPdependent protein kinase pathway (PKG) and induces acrosome reactions in pig, cow and human sperm (Zamir et al 1995, Rotem et al 1998, Zhang et al 2006. This reaction might provide additional evidence regarding the role of ANP as a human sperm chemoattractant (Zamir et al 1993, Anderson et al 1995.…”

Section: Chemotaxismentioning

confidence: 99%

Oviduct: roles in fertilization and early embryo development

Winuthayanon

2017

Journal of Endocrinology

206

191

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Animal oviducts and human Fallopian tubes are a part of the female reproductive tract that hosts fertilization and pre-implantation development of the embryo. With an increasing understanding of roles of the oviduct at the cellular and molecular levels, current research signifies the importance of the oviduct on naturally conceived fertilization and pre-implantation embryo development. This review highlights the physiological conditions within the oviduct during fertilization, environmental regulation, oviductal fluid composition and its role in protecting embryos and supplying nutrients. Finally, the review compares different aspects of naturally occurring fertilization and assisted reproductive technology (ART)-achieved fertilization and embryo development, giving insight into potential areas for improvement in this technology.

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Section: Chemotaxismentioning

confidence: 99%

Oviduct: roles in fertilization and early embryo development

Winuthayanon

2017

Journal of Endocrinology

206

191

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“…aggregation, chemotaxis, computer-aided sperm analysis, heat, hyperactivation motility A variety of chemicals and hormones, such as progesterone or atrial natriuretic peptide, cause chemotaxis of sperm [6,13,15,23]. It is important to understand the concept of sperm attraction and why infertility occurs in dysfunctional sperm.…”

Section: Introductionmentioning

confidence: 99%

Aggregation of Human Sperm at Higher Temperature Is Due to Hyperactivation

Keppler

Chan

Patton

et al. 1999

Archives of Andrology

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“…Studies that have used atrial natriuretic peptide as a chemoattractant for human sperm have suggested the involvement of a guanylate cyclase receptor (39,40) similar to the resact receptor of sea urchin sperm (41). However, mechanistic information for naturally occurring chemoattractants in vertebrates such as follicular fluid is not available.…”

Section: Discussionmentioning

confidence: 99%

Allurin, a 21-kDa sperm chemoattractant from Xenopus egg jelly, is related to mammalian sperm-binding proteins

Olson

Xiang

Ziegert

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

119

111

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Previously, we demonstrated that a protein from Xenopus egg jelly exhibits sperm chemoattractant activity when assayed by either video microscopy or by sperm passage across a porous filter. Here we describe the isolation and purification of allurin, the protein responsible for this activity. Freshly oviposited jellied eggs were soaked in buffer, and the conditioned medium was loaded onto an anion exchange column and eluted with an NaCl gradient. The active fraction was purified further by RP-HPLC, the chemoattractant protein appearing as a single sharp peak. The amino acid sequence of the protein, determined by direct sequencing and cloning of cDNAs coding for the protein, consisted of 184 amino acids having a molecular mass of 21,073 Da. The protein shares homology with the mammalian cysteine-rich secretory protein (CRISP) family that includes testes-specific spermatocyte protein 1, a cell adhesion protein which links spermatocytes to Seritoli cells, and acidic epididymal glycoproteins that bind to sperm and have been implicated in sperm-egg fusion. Phylogenetic analysis suggests that allurin evolved from the ancestral protein that gave rise to the mammalian CRISP family. Addition of allurin to this family portends that the CRISP family represents a group of ''sperm escort'' proteins, which bind to sperm at various steps in their life history, facilitating passage from one functional stage to the next. Allurin stands out in this regard, representing both the first vertebrate sperm chemoattractant to be purified and sequenced and the first member of the CRISP family to be found in the female reproductive tract. sperm chemotaxis ͉ fertilization ͉ TPX-1 ͉ AEG ͉ CRISP

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Atrial Natriuretic Peptide Attracts Human Spermatozoa in Vitro

Cited by 47 publications

References 0 publications

Oviduct: roles in fertilization and early embryo development

Oviduct: roles in fertilization and early embryo development

Aggregation of Human Sperm at Higher Temperature Is Due to Hyperactivation

Allurin, a 21-kDa sperm chemoattractant from Xenopus egg jelly, is related to mammalian sperm-binding proteins

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