Atrial natriuretic peptide and red cell 2,3-diphosphoglycerate in patients with chronic mountain sickness

Abstract

These findings suggest that overproduction of ANP and 2,3-DPG at high altitudes may play an important role in the pathophysiology of chronic mountain sickness.

SENP1, but not fetal hemoglobin, differentiates Andean highlanders with chronic mountain sickness from healthy individuals among Andean highlanders

“…Previous studies in Han Chinese and Tibetans have reported high levels of BNP, vascular endothelial growth factor, and endothelin-1 in individuals with CMS compared with healthy highlanders [43,44]. We measured pro-BNP levels in HAs and those with CMS, but obtained different results.…”

Atrial natriuretic peptide-dependent modulation of hypoxia-induced pulmonary vascular remodeling

“…In clinical studies, a significant negative correlation between pulmonary oxygen tension, plasma ANP level, pulmonary artery pressure and pulmonary vascular resistance has been observed in normal subjects and patients with heart and lung disease (Adnot et al, 1989;Chen, 2005;Ge et al, 2001;Klinger and Cutaia, 1996). ANP binds to type A natriuretic Life Sciences 79 (2006) 1357 -1365 www.elsevier.com/locate/lifescie peptide receptors (NPR-A) in the pulmonary circulation, relaxing preconstricted pulmonary arteries and inducing pulmonary vasodilation in rat, dog or human exposed to hypoxia (Foster et al, 1997;Hohne et al, 2003;Jin et al, 1990Jin et al, , 1991Rogers et al, 1997).…”

Plasma proANP1-98 Response During High Altitude Stress: Effect of Age and Ethnicity

“…This is an important observation as it is well known that the incidence of chronic mountain sickness increases with age, and the disease is associated with overproduction of ANP. 12,31,32 The hemoglobin value of Ͻ21.3 32 in HANs of this study rules out excessive erythrocytosis.…”