Atrial Natriuretic Factor Inhibits Vasotocin-Induced Water Reabsorption in the Toad Urinary Bladder

Samson, Willis K.; Vanatta, John C.

doi:10.3181/00379727-181-rc1

Cited by 30 publications

(9 citation statements)

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“…Because our subjects may have received a submaximal water load, however, we cannot entirely exclude the possibility that the increase in free water resulted from events in the collecting duct, even including inhibition of vasopressin release and/or antagonism of vasopressin action. In this regard, ANF has been shown to decrease plasma vasopressin in dehydrated or hemorrhaged animals (12) and to antagonize vasotocin-induced water transport by the toad urinary bladder (42). Further study will therefore be required to clarify the mechanism(s) of ANF-induced water diuresis.…”

Section: Resultsmentioning

confidence: 99%

Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion.

Cody¹,

Atlas²,

Laragh³

et al. 1986

J. Clin. Invest.

684

183

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We investigated atrial natriuretic factor (ANF) in humans, measuring plasma immunoreactive (ir) ANF (in femtomoles per milliliter), and renal, hormonal, and hemodynamic responses to ANF infusion, in normal subjects (NL) and congestive heart failure patients (CHF). Plasma irANF was 11±0.9 fmol/ml in NL and 71±9.9 in CHF (P < 0.01); the latter with twofold night ventricular increment (P < 0.05). In NL, ANF infusion of 0.10 ig/ kg per min (40 pmol/kg per min) induced increases (P < 0.05) of absolute (from 160±23 to 725±198 iseq/min) and fractional(1-4%) sodium excretion, urine flow rate (from 10±1.6 to 20±2.6 ml/min), osmolar (from 3.2±0.6 to 6.8±1.2 ml/min) and free water (from 6.8±1.6 to 13.6±1.6 ml/min) clearances, and filtration fraction (from 20±1 to 26±2%). Plasma renin and aldosterone decreased 33% and 40%, respectively (P < 0.01). Systolic blood pressure fell (from 112±3 to 104±5 mmHg, P < 0.05) in seated NL; but in supine NL, the only hemodynamic response was decreased pulmonary wedge pressure (from 11±1 to 7±1 mmHg, P < 0.05). In CHF, ANF induced changes in aldosterone and pulmonary wedge pressure, cardiac index, and systemic vascular resistance (all P < 0.05); however, responses of renin and renal excretion were attenuated. ANF infusion increased hematocrit and serum protein concentration by 5-7% in NL (P < 0.05) but not in CHF.

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Section: Resultsmentioning

confidence: 99%

Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion.

Cody¹,

Atlas²,

Laragh³

et al. 1986

J. Clin. Invest.

684

183

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“…Dillingham and Anderson (33) have also reported that ANF inhibits vasopressin-stimulated osmotic water permeability in rabbit cortical collecting ducts, although 2 nM ANF was required for a significant effect; and Samson and Vanetta (34) have reported that ANF inhibits vasotocin-induced water reabsorption in the toad urinary bladder.…”

Section: Discussionmentioning

confidence: 99%

Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.

Nonoguchi¹,

Sands²,

Knepper³

1988

J. Clin. Invest.

110

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“…As ANF has been shown to inhibit the hormone-induced cAMP accumulation in several systems, 7 ' ' 6i l7 it might interfere with the action of AVP and thereby limit water reabsorption in the collecting duct. Such an interaction between ANF and antidiuretic hormone has been shown to occur in isolated perfused CCT of the rabbit 24 as well as in the urinary bladder of the toad, 25 a tissue that shares many similarities with the mammalian collecting duct. In the CCT the effect of ANF on the hydraulic conductivity response induced by chlorophenylthio-cAMP or forskolin was also investigated.…”

Section: Discussionmentioning

confidence: 98%

Effects of atrial natriuretic factor and vasopressin on cyclic nucleotides in cultured kidney cells.

1988

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The cellular mechanism of the action of atrial natriuretic factor (ANF) is thought to involve activation of guanylate cyclase. Increasing evidence shows a direct tubular effect of ANF. Part of the ANF-induced diuresis has been suggested to be due to inhibition of the action of arginine vasopressin (AVP) in the cortical collecting tubule. In this study we investigated the effect of ANF on cyclic nucleotide production in primary cultures of cortical collecting tubule cells immunodissected with a monoclonal antibody. ANF caused a dose-dependent stimulation in cyclic guanosine 3',5'-monophosphate (cGMP) production; the half-maximal stimulation was observed at approximately 1 nM of ANF. ANF (0.01-100 nM) had no effect on cyclic adenosine 3',5'-monophosphate (cAMP) accumulation in cortical collecting tubule cultures. AVP caused a dose-dependent increase in cAMP production, and this effect was not altered by the simultaneous addition of ANF (100 nM). Similarly, ANF-induced cGMP stimulation was not influenced by AVP (10 nM). We conclude that 1) ANF has a direct stimulatory action on cGMP production by cultured cortical collecting tubule cells and 2) any interaction between ANF and AVP is likely to occur at steps distal to cyclic nucleotide formation.

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Atrial Natriuretic Factor Inhibits Vasotocin-Induced Water Reabsorption in the Toad Urinary Bladder

Cited by 30 publications

References 0 publications

Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion.

Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion.

Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.

Effects of atrial natriuretic factor and vasopressin on cyclic nucleotides in cultured kidney cells.

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