Atrial natriuretic factor: a protective role after acute renal ischemia?: Is there room for it in kidney transplantation?*

Gianello, Pierre; Squifflet, Jean‐Paul; Carlier, Marianne; Lambotte, Luc; Ketelslegers, J. M.; Alexandre, Guy P.

doi:10.1111/j.1432-2277.1990.tb01885.x

Cited by 2 publications

(2 citation statements)

References 58 publications

(33 reference statements)

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“…These have included the administration of intravenous mannitol [11], intravenous furosemide, and saline infusion [12]. More recent data has accumulated in regard to the use of calcium channel blocking drugs, and atrial natriuretic peptide as alternative agents to protect against RAARF [7,14]. Furthermore, the use of low osmolar radiocontrast media has been found to be associated with a decreased incidence of RAARF as compared to high osmolar agents, particularly in patients with diabetes mellitus and underlying renal insufficiency [3].…”

Section: Discussionmentioning

confidence: 99%

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Negative fluid balance and the occurrence of radiocontrast associated acute renal failure

Pfaffle

Moses

Chan

et al. 1994

Geriatric Nephrol Urol

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The factors that influence the occurrence and course of radiocontrast associated acute renal failure (RAARF) were evaluated in ten elderly patients who developed postcardiac catheterization renal failure following the use of low osmolar (iohexol) radiocontrast material. Data from these patients was compared to that of ten similar patients who did not develop RAARF. Mean ages (73 -4-1.2 vs. 72 4-1.7 years, p > 0.05), and baseline serum creatinines (1.7 -4-0.1 vs. 1.8 -4-0.1 mg/dl, p > 0.05), were not different. The amount of contrast material administered was similar in both groups. Mean fluid balance in patients with RAARF was negative 571 -4-107 ml on the study day, while patients without RAARF were positive 707 -4-222 ml (p < 0.05). There were no significant differences between either group in regard to concomitant medications, or associated diseases. Also, no significant differences between the prophylactic use of furosemide infusion or the occurrence of diabetes mellitus were observed in either group. There was, however, an increased risk for RAARF in patients with diabetes mellitus who also developed negative fluid balance (p < 0.05). The data suggest that negative fluid balance of relatively small degree (500 ml) in association with the administration of radiocontrast material may be a major factor in the development of RAARE

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Section: Discussionmentioning

confidence: 99%

“…Differences between the groups of patients with and without RAARF were analyzed by Fisher's exact test for dichotomous variables and by independent sample t-tests for continuous level variables [14]. An alpha level of 0.05 was established for statistical significance.…”

Section: Methodsmentioning

confidence: 99%

Negative fluid balance and the occurrence of radiocontrast associated acute renal failure

Pfaffle

Moses

Chan

et al. 1994

Geriatric Nephrol Urol

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Effects of apigenin on the expression levels of B‑cell lymphoma‑2, Fas and Fas ligand in renal ischemia‑reperfusion injury in rats

Liu

Wang

et al. 2017

Exp Ther Med

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The aim of the present study was to investigate the effect and possible mechanism of apigenin on renal ischemia-reperfusion (I/R) injury in rats, as well as in in vitro experiments. In total, 36 rats were subjected to 45 min of renal ischemia, with or without treatment prior to ischemia with different concentrations of apigenin (2, 10 and 50 mg/kg) administered intravenously. All rats were sacrificed at 24 h after I/R injury. The serum creatinine (Cr) and blood urea nitrogen (BUN) levels were analyzed, and histological examination was conducted. In addition, the expression levels of B-cell lymphoma 2 (Bcl-2) and Fas/Fas ligand (FasL) were detected by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction and western blot analysis. For in vitro experiments, the NRK-52E cell line was employed. The viability, apoptosis and expression levels of Fas, FasL and Bcl-2 were examined in the culture of NRK-52E cells following the I/R. The results indicated that apigenin significantly decreased the levels of serum Cr and BUN induced by renal I/R, demonstrating an improvement in renal function. The histological evidence of renal damage associated with I/R was also mitigated by apigenin in vivo. Furthermore, apigenin increased the cell viability and decreased cell apoptosis in the culture of NRK52E after I/R in vitro. Compared with the I/R group, the expression of Bcl-2 was upregulated and the expression levels of Fas and FasL were downregulated by apigenin at the mRNA and protein levels in vivo and in vitro. In conclusion, apigenin appeared to increase the expression of Bcl-2 and reduce Fas/FasL expression in renal I/R injury, providing evident protection against renal I/R injury in rats.

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Atrial natriuretic factor: a protective role after acute renal ischemia?: Is there room for it in kidney transplantation?*

Cited by 2 publications

References 58 publications

Negative fluid balance and the occurrence of radiocontrast associated acute renal failure

Negative fluid balance and the occurrence of radiocontrast associated acute renal failure

Effects of apigenin on the expression levels of B‑cell lymphoma‑2, Fas and Fas ligand in renal ischemia‑reperfusion injury in rats

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