Atrial Natriuretic Factor

Bold, Adolfo J. de; Sonnenberg, H.; Ackermann, Uwe; Blaine, Edward H.; Briggs, Josephine P.; Cole, Barbara R.; Keeler, R.; Solomon, Sidney; Spinelli, Frank; Trippodo, N. C.; Maack, Thomas

doi:10.1007/978-1-4612-5284-9_24

Cited by 9 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ANP is secreted into the blood and is capable of inducing natriuresis and diuresis as well as being able to lower the blood pressure (1,5,17,22). Studies have shown that in water-deprived animals there is a significant decrease of plasma ANP levels (11,21) and a corresponding increase of plasma ANP in volume-loaded animals (13).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Immunohistochemical localization of ANP in the pulmonary veins of the rat.

Larsen

Arjamaa

Järvinen

et al. 1987

Acta Histochem. Cytochem

View full text Add to dashboard Cite

The presence of atrial natriuretic peptide (ANP) in the striated myocytes of pulmonary veins in rat was studied by immunohistochemical methods. In general, the immunoreactivity of the pulmonary myocardium was less intense than found in the left atrium.In the inner circular layer of the pulmonary myocardium, some striated myocytes were moderately granular stained.The staining was mainly localized to the paranuclear areas, while some granules were also distributed throughout the sarcoplasm.Cardiac muscle cells are present in the adventitia of the pulmonary venous wall of the rat and other rodentia (7-10, 12, 15, 18). The striated muscle coat of the pulmonary veins is continuous with the myocardium of the left atrium, and contributes to the major thickness of the wall in the extrapulmonary veins, whereas, it turn thinner in the intrapulmonary veins and finally disappears. The striated myocytes are structurally similar to those found in the atrium. Also, "atrial specific granules" (ASG) have been reported to be present in some of the myocytes of the extrapulmonary portion of the veins (14). These specific granules, including A-granules and B-granules (2), are morphologically similar to the ASG of the atria. In the atria, the specific granules have been shown to contain "atrial naturiuretic peptide" (ANP) by immunocytochemical methods (3,4,16,19,23,25). ANP has been demonstrated to play a role in the body fluid homeostasis by increasing the natriuresis and the diuresis as well as being capable of reducing the blood pressure (1,5,17,22).Based on the structural similarities between the ASG in the striated heart muscle cells of the pulmonary veins and the atria, this study has aimed at demonstrating the presence of ANP in the pulmonary myocardium by immunohistochemical methods. MATERIALS AND METHODS Tissue samples:The heart of the Wistar rats was arrested by injection of ice-cold fixative into the right atrium. The fixative used was composed of 4% formaldehyde, 0.25 M sucrose and 0.01 M sodium phosphate buffer (pH 7.4). Thereafter the hearts were excised 471

show abstract

Section: Discussionmentioning

confidence: 99%

“…In the atria, the specific granules have been shown to contain "atrial naturiuretic peptide" (ANP) by immunocytochemical methods (3,4,16,19,23,25). ANP has been demonstrated to play a role in the body fluid homeostasis by increasing the natriuresis and the diuresis as well as being capable of reducing the blood pressure (1,5,17,22).…”

mentioning

confidence: 99%

Immunohistochemical localization of ANP in the pulmonary veins of the rat.

Larsen

Arjamaa

Järvinen

et al. 1987

Acta Histochem. Cytochem

View full text Add to dashboard Cite

show abstract

“…In this study, the authors showed that the deficient 5HT transmission in forebrain regions involved in water-electrolyte regulation is associated with sodium retention and increased water intake. ANP, the hormone produced by atrial cardiomyocytes, is critically involved in water-electrolyte regulation, and its inhibitory influence on sodium appetite and water intake has been demonstrated (de Bold et al 1981(de Bold et al , 1991Antunes-Rodrigues et al 1985). More recently, Franchini et al (2002) obtained evidence consistent with the involvement of 5HT pathways in this behaviour by showing an increase in c-Fos expression in rat midbrain raphe neurons during the spontaneous or induced manifestation of sodium appetite.…”

mentioning

confidence: 99%

Effect of Brain Serotoninergic Stimulation on Sodium Appetite of Euthyroid and Hypothyroid Rats

Badauê‐Passos¹,

Ventura²,

Silva³

et al. 2003

Experimental Physiology

View full text Add to dashboard Cite

The aim of the present work was to investigate the role of the serotoninergic system in the control of sodium appetite of hypothyroid rats (HTR) by administering drugs that affect the serotoninergic activity, and to compare the same homeostatic behaviour in euthyroid rats (ETR) also given these drugs. Fenfluramine (FEN; 5.0 mg kg _1 , I.P.), which releases serotonin in the brain, significantly reduced the intake of 1.8 % NaCl in HTR subjected to water and sodium depletion (depleted) or water, sodium and food deprivation (deprived) by 31 and 45 %, respectively, 120 min after FEN injection, compared to HTR that received vehicle alone. Similarly, administration of FEN to ETR reduced 1.8 % NaCl intake in depleted and deprived rats by 64 and 46 %, respectively. The presynaptic serotonin reuptake inhibitor fluoxetine (20.0 mg kg _1 , I.P.) led to the inhibition of sodium appetite in HTR during the initial 30 min in depleted rats and for up to 60 min post-injection in deprived rats, while sodium appetite inhibition persisted for longer periods in ETR. The 5HT2C receptor agonist mCPP (5.0 mg kg _1 , I.P.) caused a drastic reduction in sodium appetite in HTR and ETR in depleted and deprived rats, respectively, after 120 min. Prior administration of the 5HT2C receptor antagonist LY53857 (5.0 mg kg _1 , I.P.) completely blocked the inhibitory action of mCPP on sodium appetite in both HTR and ETR. In summary, our results suggest that the recruitment of serotoninergic neurons involved in the modulation of sodium appetite seems to be decreased in hypothyroidism due to a probable deficiency in the cerebral signalling pathway.

show abstract

“…20 Hypofunctions of these neurons have been implicated in the pathophysiology of excess water drinking or polydipsia, a symptom that is commonly seen in chronic schizophrenia. 21,22 As such, the effects of the ovarian steroid on ANP neurons may not be directly associated with the mechanism underlying positive and negative symptoms of the illness.…”

Section: Molecular Psychiatrymentioning

confidence: 99%

Progesterone modulation of D5 receptor expression in hypothalamic ANP neurons, the role of estrogen

et al. 2000

View full text Add to dashboard Cite

Increasing evidence now suggest that estrogen may play a protective role against the onset and incidence of psychosis in schizophrenia. In women, the onset of schizophrenia occurs far later than it does in men and there is a peak incidence of the illness after menopause. 2-4 Moreover, estrogen supplements given together with antipsychotic drugs improve clinical outcomes. 6 One of the theories postulates that estrogen induces neurons in critical regions of the brain to respond favourably to dopamine in a manner not yet understood. This is consistent with the 'Dopamine Hypothesis' of schizophrenia, which postulates an overactivity of dopamine neurons or heightened responsiveness of D 2 receptors to dopamine or both may play an important role in positive symptoms of the illness. 7,8 Recent evidence from PET scan studies further suggests that reduced abundance or underfunction of D 1 D 5 receptors or both in the prefrontal cortex may link to the negative symptom of schizophrenia. 1 Taken together, it now appears that an overactivity of D 2 -like receptors and an underactivity of D 1 -like receptors or both may underlie the pathophysiology of the illness. This notion is substantiated by clinical observations as anti-psychotic drugs that block D 2 receptors are effective in alleviating positive symptoms, 9,10 whilst those enhancing the activity of D 1 -like receptors may improve negative symptoms. 11 Recently, we have reported that estrogen selectively augments the expression of D 5 receptors, a member of the D 1 -like receptor family, but not D 1 receptors, in central neurons. 5 Interestingly, D 5 receptors are constitutively active and play an important role in maintaining functional activities of the host cells through the cAMP pathway. 12 The possibility that this neurobiological effect of estrogen on D 5 receptors may affect critical regions of the brain and confer protection against psychosis in schizophrenia needs to be considered. However, besides estrogen, mammalian ovaries also produce another important ovarian steroid, progesterone. In women, progesterone and estrogen are produced and released from ovaries in a sequential manner during the menstrual cycle. The two steroids interact at many levels to induce neurophysiological changes pertinent to behavioural modification. 13,14 Unlike estrogen, the role of progesterone in modulating dopamine responsiveness in central neurons, however, remains elusive.Employing a well characterised long-term rat hypothalamic cell culture system, we have recently identified that atrial natriuretic factor (ANP)-producing neurons constitute a common convergent site for integration of ovarian steroid and dopamine actions. 5 In this system, estrogen induces the expression of progesterone receptors in ANP neurons and augments neuronal functions by increasing the expression of constitutively active D 5 receptors that generate cAMP in a ligand-independent manner. Adopting the same approach, we have now exploited our hypothalamic culture system to examine the effect of progesterone, a...

show abstract

Atrial Natriuretic Factor

Cited by 9 publications

References 0 publications

Immunohistochemical localization of ANP in the pulmonary veins of the rat.

Immunohistochemical localization of ANP in the pulmonary veins of the rat.

Effect of Brain Serotoninergic Stimulation on Sodium Appetite of Euthyroid and Hypothyroid Rats

Progesterone modulation of D5 receptor expression in hypothalamic ANP neurons, the role of estrogen

Contact Info

Product

Resources

About