Atrial Heterogeneous Autonomic Neural Remodeling in Rabbits with Experimental Atrial Fibrillation and the Effect of Intervention by Rosuvastatin

Zhang, Bei; Wang, Ximin; Zhan, Li; Wang, Weizong; Zhang, Yong; Liu, Ju; Hou, Yinglong

doi:10.1111/pace.12859

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…These results demonstrate that the decreased density of sympathetic nerves in the atrium increases autonomic nerve dysfunction during AF occurrence and maintenance by affecting the electrophysiological characteristics, including APD, ERP, and alternans threshold (45). Therefore, during heterogeneous autonomic nerve dysfunctions after AF, the most evident changes in homogeneous nerve distribution in the atrial septum may indicate a high incidence of focal excitability and reentry formation in AF (43).…”

Section: S1r and Neuron Remodelingmentioning

confidence: 75%

Chronic stimulation of the sigma-1 receptor ameliorates autonomic nerve dysfunction and atrial fibrillation susceptibility in a rat model of depression

Liu

Yang

et al. 2018

American Journal of Physiology-Heart and Circulatory Physiology

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Aims The present study assessed the effect of Sigma-1 receptor (S1R) stimulation on autonomic nerve dysfunction and atrial fibrillation susceptibility in rat depression models. Methods and Results Male rats were randomly divided into four treatment groups for four weeks: saline (CTL), saline+ intragastric administration of SA4503 (agonist of the S1R, CTS), chronic unpredictable mild stress (CUMS) to produce depression(MDD), and CUMS+ intragastric administration of SA4503 (MDS). After 4 weeks, depression-like behaviors, such as sucrose preference, body weight, and immobility during forced swimming improved in the MDS group. Compared with CTL, MDD showed augmented sympathetic activity, reduced parasympathetic activity, decreased heart rate variability, and significantly lowered S1R expression in the atrium and in hippocampal tissues (all P<0.01). However, the MDS group showed mitigation of most of the above alterations and improved electrical remodeling (all P<0.01). Furthermore, the MDS group showed shortened activation latencies, increases in the effective refractory period, and lower frequency of AF incidence duration and fibrosis compared to MDD (all P<0.01). Conclusions The results indicate that S1R stimulation reduces sympathetic activity and atrial fibrillation susceptibility by improving depressive behaviours, modulating cardiac autonomic nerve balance, lightening nerve remodeling, and up-regulating S1R expression.

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Section: S1r and Neuron Remodelingmentioning

confidence: 75%

Chronic stimulation of the sigma-1 receptor ameliorates autonomic nerve dysfunction and atrial fibrillation susceptibility in a rat model of depression

Liu

Yang

et al. 2018

American Journal of Physiology-Heart and Circulatory Physiology

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“…A recent study observed the effects of rosuvastatin on effective atrial refractory pacing, the induction of atrial fibrillation, and changes in atrial autonomic nerves in an AF model induced by rapid pacing in rabbits. The results showed that persistent rapid atrial pacing can cause heterogeneous autonomic neural remodeling in different parts of the atrium and can lead to AF, which can be reversed by rosuvastatin [ 25 ]. Huang et al found that in patients receiving statin in clinical practice, the CHADS 2 score can help identify AMI patients who will benefit from the use of statin to prevent AF [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of 2 Different Dosages of Rosuvastatin on Prognosis of Acute Myocardial Infarction Patients with New-Onset Atrial Fibrillation in Jinan, China

et al. 2020

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Epicardial fat and atrial fibrillation: the perils of atrial failure

et al. 2022

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Obesity is a heterogeneous condition, characterized by different phenotypes and for which the classical assessment with body mass index may underestimate the real impact on cardiovascular (CV) disease burden. An epidemiological link between obesity and atrial fibrillation (AF) has been clearly demonstrated and becomes even more tight when ectopic (i.e. epicardial) fat deposition is considered. Due to anatomical and functional features, a tight paracrine cross-talk exists between epicardial adipose tissue (EAT) and myocardium, including the left atrium (LA). Alongside—and even without—mechanical atrial stretch, the dysfunctional EAT may determine a pro-inflammatory environment in the surrounding myocardial tissue. This evidence has provided a new intriguing pathophysiological link with AF, which in turn is no longer considered a single entity but rather the final stage of atrial remodelling. This maladaptive process would indeed include structural, electric, and autonomic derangement that ultimately leads to overt disease. Here, we update how dysfunctional EAT would orchestrate LA remodelling. Maladaptive changes sustained by dysfunctional EAT are driven by a pro-inflammatory and pro-fibrotic secretome that alters the sinoatrial microenvironment. Structural (e.g. fibro-fatty infiltration) and cellular (e.g. mitochondrial uncoupling, sarcoplasmic reticulum fragmentation, and cellular protein quantity/localization) changes then determine an electrophysiological remodelling that also involves the autonomic nervous system. Finally, we summarize how EAT dysfunction may fit with the standard guidelines for AF. Lastly, we focus on the potential benefit of weight loss and different classes of CV drugs on EAT dysfunction, LA remodelling, and ultimately AF onset and recurrence.

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Atrial Heterogeneous Autonomic Neural Remodeling in Rabbits with Experimental Atrial Fibrillation and the Effect of Intervention by Rosuvastatin

Abstract: Persistent rapid atrial pacing can lead to heterogeneous ANR in different parts of the rabbit atrium and may cause AF, which can be reversed by rosuvastatin. The inhibitory function of rosuvastatin may be associated with its role in reversing atrial ANR.

Cited by 4 publications

References 20 publications

Chronic stimulation of the sigma-1 receptor ameliorates autonomic nerve dysfunction and atrial fibrillation susceptibility in a rat model of depression

Chronic stimulation of the sigma-1 receptor ameliorates autonomic nerve dysfunction and atrial fibrillation susceptibility in a rat model of depression

Effect of 2 Different Dosages of Rosuvastatin on Prognosis of Acute Myocardial Infarction Patients with New-Onset Atrial Fibrillation in Jinan, China

Epicardial fat and atrial fibrillation: the perils of atrial failure

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