Atrial fibrillation risk on Parkinson’s disease – a systematic review and meta-analysis

Cereja, Fátima; Alves, Mariana; Ferreira, Joaquim J.; Caldeira, Daniel

doi:10.1007/s11239-023-02792-z

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…[ [246][247][248][249] Rheumatoid arthritis Small, significant association, but confounded with use of small molecule drugs. Also associated with greater risk of cardiovascular disease.…”

Section: Comments Selected Referencesmentioning

confidence: 99%

Fibrinaloid Microclots and Atrial Fibrillation

Kell,

Lip,

Pretorius

2024

Biomedicines

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Atrial fibrillation (AF) is a comorbidity of a variety of other chronic, inflammatory diseases for which fibrinaloid microclots are a known accompaniment (and in some cases, a cause, with a mechanistic basis). Clots are, of course, a well-known consequence of atrial fibrillation. We here ask the question whether the fibrinaloid microclots seen in plasma or serum may in fact also be a cause of (or contributor to) the development of AF. We consider known ‘risk factors’ for AF, and in particular, exogenous stimuli such as infection and air pollution by particulates, both of which are known to cause AF. The external accompaniments of both bacterial (lipopolysaccharide and lipoteichoic acids) and viral (SARS-CoV-2 spike protein) infections are known to stimulate fibrinaloid microclots when added in vitro, and fibrinaloid microclots, as with other amyloid proteins, can be cytotoxic, both by inducing hypoxia/reperfusion and by other means. Strokes and thromboembolisms are also common consequences of AF. Consequently, taking a systems approach, we review the considerable evidence in detail, which leads us to suggest that it is likely that microclots may well have an aetiological role in the development of AF. This has significant mechanistic and therapeutic implications.

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“…[ [246][247][248][249] Rheumatoid arthritis Small, significant association, but confounded with use of small molecule drugs. Also associated with greater risk of cardiovascular disease.…”

Section: Comments Selected Referencesmentioning

confidence: 99%

Fibrinaloid Microclots and Atrial Fibrillation

Kell,

Lip,

Pretorius

2024

Biomedicines

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“…Previous studies have indicated that PD is associated with an increased risk of ischemic stroke [7‒9], while atrial fibrillation has been found to be associated with stroke in various patient groups [10]. However, some observational findings do not support an increased risk of atrial fibrillation in patients with PD [11, 12]. Whether causal relationship exists between PD and AF warrants further study.…”

Section: Introductionmentioning

confidence: 98%

Causal Relationship between Parkinson’s Disease with Heart and Vascular Disease: A Two-Sample Mendelian Randomization Study

Chen,

Zhang,

et al. 2024

Eur Neurol

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Introduction: The aim of this study was to investigate the causal relationship between Parkinson’s disease (PD) and myocardial infarction (MI), atrial fibrillation and flutter (AF), and venous thromboembolism (VTE) by Mendelian randomization (MR) analysis. Methods: By using data from publicly available genome-wide association studies from databases, single nucleotide polymorphisms were screened as instrumental variables, and the MR analysis was finished by inverse-variance weighted (IVW), MR-egger, weighted median methods. Results: The primary IVW method showed a negative association between genetically predicted PD and risk of MI (OR = 0.9989; 95% CI: 0.9980–0.9998; p = 0.02). However, PD was not significantly associated with AF or VTE. Conclusion: This study suggests a negative association between PD with MI, which implies that PD has a protective effect on MI.

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Atrial fibrillation risk on Parkinson’s disease – a systematic review and meta-analysis

Cited by 2 publications

References 14 publications

Fibrinaloid Microclots and Atrial Fibrillation

Fibrinaloid Microclots and Atrial Fibrillation

Causal Relationship between Parkinson’s Disease with Heart and Vascular Disease: A Two-Sample Mendelian Randomization Study

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