Atrial Fibrillation Is Associated with a Marker of Endothelial Function and Oxidative Stress in Patients with Acute Myocardial Infarction

Stamboul, Karim; Lorin, Julie; Lorgis, Luc; Guenancia, Charles; Beer, Jean‐Claude; Touzery, Claude; Rochette, Luc; Vergely, Catherine; Cottin, Yves; Zeller, Marianne

doi:10.1371/journal.pone.0131439

Cited by 22 publications

(16 citation statements)

References 40 publications

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“…Asymmetric dimethylarginine has been proposed to have prognostic value in determining AF in high‐risk patients (Stamboul et al, 2015) and the adverse events such as mortality and stroke in AF (Chao et al, 2013; Horowitz et al, 2018). Treatment with 10 mg daily rosuvastatin for 3 months following elective electrical cardioversion decreased recurrence of AF through reduction of ADMA levels (Xia, Yin, Li, Song, & Qu, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Higher ADMA levels were associated with increased risk of AF recurrence following electrical cardioversion (Xia et al, 2008) and catheter ablation (Yang et al, 2011). It has been suggested that ADMA could have prognostic value in predicting AF in high‐risk patients (Stamboul et al, 2015). Besides, studies have indicated the predictive value of ADMA in determining the adverse events such as mortality and stroke in AF (Chao et al, 2013; Horowitz et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Effect of fish oil on circulating asymmetric dimethylarginine and adiponectin in overweight or obese patients with atrial fibrillation

Khorrami

Hosseinzadeh‐Attar

Esmaillzadeh

et al. 2020

Food Science & Nutrition

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Obesity and adipose-derived peptides might be involved in the pathogenesis of atrial fibrillation (AF). Adiponectin plays a major role in the modulation of several metabolic pathways, and asymmetric dimethylarginine (ADMA) has been suggested to be predictive of AF and associated adverse events. The aim of this study was to investigate the effect of fish oil supplementation on circulating adiponectin and ADMA in overweight or obese patients with persistent AF. In this randomized, double-blind, placebo-controlled trial, 80 overweight or obese (body mass index (BMI) ≥ 25 kg/m 2 ) patients with persistent AF were randomly assigned to two groups to receive either 2 g/day fish oil or placebo, for 8 weeks. Serum levels of adiponectin and ADMA, and anthropometric indexes were measured. This study showed that serum adiponectin concentrations increased significantly following fish oil supplementation compared with the placebo group (13.15 ± 7.33 vs. 11.88 ± 6.94 µg/ml; p = .026). A significant reduction was also observed in serum ADMA levels in the fish oil compared with the placebo group following the intervention (0.6 ± 0.13 vs. 0.72 ± 0.15 µmol/L; p = .001). The changes in serum adiponectin and ADMA concentrations remained significant after adjustments for baseline values, age, sex, and changes of BMI and waist circumference (p = .011 and p = .001, respectively). In conclusion, 8 weeks supplementation with fish oil increased serum adiponectin and decreased ADMA concentrations in overweight or obese patients with persistent AF. As adiponectin and ADMA are suggested to be involved in many pathways associated with AF, the current findings might be promising in the clinical management of this disease, an issue that needs further investigations. K E Y W O R D Sadiponectin, asymmetric dimethylarginine, atrial fibrillation, fish oil, obesity

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of fish oil on circulating asymmetric dimethylarginine and adiponectin in overweight or obese patients with atrial fibrillation

Khorrami

Hosseinzadeh‐Attar

Esmaillzadeh

et al. 2020

Food Science & Nutrition

View full text Add to dashboard Cite

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“…Similar to myeloperoxidase another marker of oxidative stress, whose atrial tissue concentrations are strongly related to AF 51 but no significant association with systemic measurements was observed, 52;53 circulating arginine derivatives may not adequately mirror the local burden and its long-term changes in relation to AF. Since ADMA has repeatedly been demonstrated to be related to ventricular and atrial arrhythmias 17;18 and AF 19;20 a lack of predictive ability for incident AF does not preclude a significant role of ADMA and arginine derivatives in pathophysiological causative pathways.…”

Section: Discussionmentioning

confidence: 99%

“…15;16 Circulating concentrations of ADMA are increased in experimental atrial tachyarrhythmias, 17 severe postoperative arrhythmias 18 and in AF. 19;20 …”

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confidence: 99%

Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation

Schnabel

Maas

Wang

et al. 2016

American Heart Journal

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Background Oxidative stress plays an important role in the development of atrial fibrillation (AF). Arginine derivatives including asymmetric dimethylarginine (ADMA) are central to nitric oxide metabolism and nitrosative stress. Whether blood concentrations of arginine derivatives are related to incidence of AF is uncertain. Methods and Results In 3310 individuals (mean age 58±10 years, 54% women) from the community-based Framingham Study we prospectively examined the relations of circulating levels of ADMA, L-arginine, symmetric dimethylarginine (SDMA), and the ratio of L-arginine/ADMA to incidence of AF using proportional hazards regression models. Over a median follow-up time of 10 years 247 AF cases occurred. Using age- and sex-adjusted regression models, ADMA was associated with a hazard ratio of 1.15 per one standard deviation increase in loge-biomarker concentration (95% confidence interval 1.02 to 1.29, P=0.02) for AF, which was no longer significant after further risk factor adjustment (hazard ratio 1.09, 95% confidence interval 0.97 to 1.23, P=0.15). Neither L-arginine nor symmetric dimethylarginine was related to new-onset AF. A clinical model comprising clinical risk factors for AF (for age, sex, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, diabetes, hypertension treatment, myocardial infarction, and heart failure) (C-statistic: 0.781; 95% confidence interval, 0.753 to 0.808) was not improved by the addition of ADMA (0.782; 95% confidence interval, 0.755 to 0.809). Conclusions ADMA and related arginine derivatives were not associated with incident AF in the community after accounting for other clinical risk factors and confounders. Its role in the pathogenesis of AF needs further refinement.

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“…[1][2][3][4][5] Unfortunately, AF is highly associated with substantial morbidity and mortality increases after myocardial infarction. [6][7][8] Editorial p. 3 Innate immune factors play important roles in most cardiac diseases. [9][10][11] As data has shown in recent research, toll-like receptors increase in either plasma or tissues as innate immune factors in ischemia heart diseases and arrhythmias diseases.…”

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confidence: 99%

Toll-Like Receptors 2 and 4 Predict New-Onset Atrial Fibrillation in Acute Myocardial Infarction Patients

Zhang

Shao

2018

Int. Heart J.

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SummaryMyocardial infarction (MI) can cause new-onset atrial fibrillation (AF) due to cardiac remodeling. As a recent study has shown, inflammatory factors are closely tied to cell death and survival in myocardial ischemia injury. Toll-like receptors (TLRs) have been shown to participate in the process of myocardial infarction as innate immune factors.The subjects were divided into 3 groups: healthy controls (n = 82), MI patients (n = 84), and AFMI (newonset atrial fibrillation after myocardial infarction) patients (n = 85). Peripheral blood mononuclear cell (PBMC) TLR mRNA expression was detected by rt-PCR. Western blot was used to analyze PBMC TLRs and their downstream signal protein expression. PBMCs were presented as TLR2 expression or TLR4 expression using flow cytometry.From mRNA to protein detection, PBMC TLR2 and TLR4 were significantly higher in the AFMI group than in the control group and MI group. A similar tendency was also observed in the expression of downstream signaling proteins. When further analyzed with TLR2 and TLR4 antibodies by flow cytometry, PBMC levels also appeared to be higher in AFMI patients than those in MI patients and the healthy control group.In our study, PBMC TLRs and their downstream signaling proteins were significantly higher in the acute myocardial infarction patients with new-onset atrial fibrillation compared with healthy people and acute myocardial infarction patients without new-onset atrial fibrillation. They have the potential to be novel biomarkers for new-onset atrial fibrillation after acute myocardial infarction.(Int Heart J 2018; 59: 64-70) Key words: Innate immune A s one component of the global burden of cardiac arrhythmia disease, atrial fibrillation (AF) is generally divided into valvular and non-valvular AF. Myocardial infarction (MI) is an independent risk factor for new-onset AF which occurs in 6% to 21% of acute MI patients due to post myocardial infarction remodeling. [1][2][3][4][5] Unfortunately, AF is highly associated with substantial morbidity and mortality increases after myocardial infarction. 6-8) Editorial p.3Innate immune factors play important roles in most cardiac diseases. [9][10][11] As data has shown in recent research, toll-like receptors increase in either plasma or tissues as innate immune factors in ischemia heart diseases and arrhythmias diseases. [12][13][14] Notably, TLR4 could directly stimulate macrophages and induce atheroma formation, while TLR4 deficiency has been shown to have a protective effect against myocardial ischemic injury. 15,16) Furthermore, there is some evidence for TLR4 in ventricular remodeling after acute myocardial infarction. 17,18) However, the effect of TLR2 on heart disease remains controversial. In TLR2 knock-out mice, there was no obvious difference in infarct size compared to wild type mice, although a negative effect on fibrosis in the non-infarcted area and a positive effect on left ventricular remodeling have been reported. 19,20) However, TLR2 also has been found to trigger atrial fibrillation and fa...

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Atrial Fibrillation Is Associated with a Marker of Endothelial Function and Oxidative Stress in Patients with Acute Myocardial Infarction

Cited by 22 publications

References 40 publications

Effect of fish oil on circulating asymmetric dimethylarginine and adiponectin in overweight or obese patients with atrial fibrillation

Effect of fish oil on circulating asymmetric dimethylarginine and adiponectin in overweight or obese patients with atrial fibrillation

Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation

Toll-Like Receptors 2 and 4 Predict New-Onset Atrial Fibrillation in Acute Myocardial Infarction Patients

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