Atrial Fibrillation Increases Sympathetic and Parasympathetic Neurons in the Intrinsic Cardiac Nervous System

Yu, Ying; Wei, Mengying; Liu, Li; Lian, Miaojun; Qu, Xiu Fen; Yu, Guang

doi:10.1111/pace.12450

Cited by 20 publications

(14 citation statements)

References 29 publications

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“…Recently, it has been shown that atrial GP neurons are hypertrophied following HF, 51,56 providing evidence of anatomical and neurochemical changes following cardiac disease 51 . Not only do the intrinsic GPs participate in triggering and initiating AF, but they also modulate the electrical remodelling of the atria 42,57 . These changes would be expected to affect neuronal cell communication, detrimentally affecting ganglionic physiology, and could in part, explain the attenuation in GP neurotransmission following HF 51,58 .…”

Section: Intrinsic Cardiac Nervous Systemmentioning

confidence: 99%

“…The cardiac ANS plays an essential role in epicardial GP regulation of AF onset and progression 40 . AF‐associated oxidative stress, 42,125 may cause cardiac nerve injury, which triggers the re‐expression of NGF or other neurotrophic factors in the non‐neuronal cells around the site of injury 42,102 . NGF over‐expression is associated with myocardial hyperinnervation and atrial fibrosis, 102,126 whereas increase in atrial sympathetic innervation contribute to the generation and maintenance of AF by exerting significant effects on automaticity, refractoriness, and conduction velocity 43,102,113,127,128 .…”

Section: The Role Of Nerve Growth Factor In Response To Pathological mentioning

confidence: 99%

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Pleiotropic activity of nerve growth factor in regulating cardiac functions and counteracting pathogenesis

Pius-Sadowska

2021

ESC Heart Failure

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Cardiac innervation density generally reflects the levels of nerve growth factor (NGF) produced by the heart-changes in NGF expression within the heart and vasculature contribute to neuronal remodelling (e.g. sympathetic hyperinnervation or denervation). Its synthesis and release are altered under different pathological conditions. Although NGF is well known for its survival effects on neurons, it is clear that these effects are more wide ranging. Recent studies reported both in vitro and in vivo evidence for beneficial actions of NGF on cardiomyocytes in normal and pathological hearts, including prosurvival and antiapoptotic effects. NGF also plays an important role in the crosstalk between the nervous and cardiovascular systems. It was the first neurotrophin to be implicated in postnatal angiogenesis and vasculogenesis by autocrine and paracrine mechanisms. In connection with these unique cardiovascular properties of NGF, we have provided comprehensive insight into its function and potential effect of NGF underlying heart sustainable/failure conditions. This review aims to summarize the recent data on the effects of NGF on various cardiovascular neuronal and non-neuronal functions. Understanding these mechanisms with respect to the diversity of NGF functions may be crucial for developing novel therapeutic strategies, including NGF action mechanism-guided therapies.

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Section: Intrinsic Cardiac Nervous Systemmentioning

confidence: 99%

Section: The Role Of Nerve Growth Factor In Response To Pathological mentioning

confidence: 99%

Pleiotropic activity of nerve growth factor in regulating cardiac functions and counteracting pathogenesis

Pius-Sadowska

2021

ESC Heart Failure

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“…Autonomic neural remodeling (higher average density and heterogeneity of both tyrosine hydroxylase and choline acetyltransferase) was shown to exist in the PV-LA junction and GPs after prolonged atrial pacing in a canine model 21,22) . An LA GP ablation alone (before the PV antrum isolation) was shown to decrease the occurrence of PV firing and to decrease the inducibility of sustained AF 23) .…”

Section: Discussionmentioning

confidence: 98%

I Impact of Atrial Fibrillation on the Vagal Response to Ganglionated Plexi Stimulation: Comparison Between Patients with and without Atrial Fibrillation

Takahashi

Watanabe

Okumura

et al. 2019

Nichidai Igaku Zasshi

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an extensive PVI was significantly associated with an AF recurrence 7-10). High-frequency stimulation from the left atrial endocardium has been used for the localization of left atrial ganglionated plexi 11). However, the degree and area of a vagal response to high-frequency stimulation to the left atrial GP sites have not been compared between patients with and without AF. The purpose of this study was to elucidate the effect of AF on the vagal response to high-frequency stimulation. Methods Study patients This study consisted of 32 AF patients (26 men, 6 women; age 55.9 ± 7.0 years) who underwent an extensive encircling PVI (EEPVI) by RFA for paroxysmal AF

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“…In a canine model of AF, Jayachandran et al showed that the density of the sympathetic nerve was increased and it played a role in the induction and maintenance of AF following myocardial infarction [ 14 – 17 ]. Moreover, Ng et al reported enhanced sympathetic and parasympathetic nerve growth in the left atrium in a canine model of heart failure and AF [ 18 , 19 ], whereas Choi et al found that AF was triggered by endogenous cardiac discharges in dogs [ 20 ]. Similar findings were observed in human AF.…”

Section: Discussionmentioning

confidence: 99%

Clinical Effects of “Selective Drug” Regulating Vagus Nerve Signal Pathway in Vagally-Mediated Atrial Fibrillation

Lou

Tang

et al. 2018

Med Sci Monit

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BackgroundThe cardiac autonomic nervous system plays a crucial role in genesis and development of atrial fibrillation (AF) through the G protein signal transduction pathway. Therefore, intervening in the G protein signal transduction pathway may be a new “selective drug” method to regulate autonomic nerve activity to prevent vagally-mediated AF.Material/MethodsSeventeen adult beagles were randomized into 3 groups: shame-operation control group (group A, n=5), empty vector gene control group (group B, n=6), and Gαi2ctp gene experimental group (group C, n=6). Group A was injected with normal saline into the anterior atrial wall, and group B and group C animals were injected with recombinant adenovirus with empty vector or Gαi2ctp vector in the same region. AF was induced by the method of rapid atrial pacing in groups B and C. To determine the clinical effect of vagal modulation, the effective refractory periods (ERP) and field action potential duration (FAPD) were evaluated by electrophysiological study. The expression levels of tyrosine hydroxylase (TH) and choline acetyl transferase (CHAT) in different parts were determined with immunohistochemistry.ResultsAfter successful Gαi2ctp gene transfer, in group B, the ERP and FAPD significantly decreased (P<0.05), and TH and CHAT expression observably increased (P<0.05), while those differences were absent between groups A and C (P>0.05).ConclusionsRecombinant adenovirus-mediated overexpression of Gαi2ctp in canine myocardial cells can interfere with the activity of the vagus nerve, reverse the development and progression of electrical remodeling, and reduce the incidence of AF.

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Atrial Fibrillation Increases Sympathetic and Parasympathetic Neurons in the Intrinsic Cardiac Nervous System

Abstract: This study provides evidence for the remodeling in atrial intrinsic cardiac ganglia in the dogs with pacing induced AF. A significant increase of sympathetic and parasympathetic neurons was present in atrial intrinsic cardiac ganglia.

Cited by 20 publications

References 29 publications

Pleiotropic activity of nerve growth factor in regulating cardiac functions and counteracting pathogenesis

Pleiotropic activity of nerve growth factor in regulating cardiac functions and counteracting pathogenesis

I Impact of Atrial Fibrillation on the Vagal Response to Ganglionated Plexi Stimulation: Comparison Between Patients with and without Atrial Fibrillation

Clinical Effects of “Selective Drug” Regulating Vagus Nerve Signal Pathway in Vagally-Mediated Atrial Fibrillation

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