Atrial Fibrillation Burden in Young Patients With Congenital Heart Disease

Abstract

The risk of AF in children and young adults with CHD was 22 times higher than that in matched control subjects. Up to the age of 42 years, 1 of 12 patients with CHD had developed AF, and 1 of 10 patients with CHD with AF had developed heart failure. The patient groups with the most complex congenital defects carried the greatest risk of AF and could be considered for targeted monitoring.

Risk of Atrial Fibrillation in Patients with Congenital Heart Disease: Results of a Propensity Score-Matched, Nationwide Cohort Study

“…This study is different from other investigations examining the association between CHD and AF in that it does not focus on AF during subsequent years for a certain type of CHD or a specified age group, making this study unique, relevant, and informative 3-8, 11-13 ).…”

“…The link between CHD and risk of incident AF has been demonstrated, mainly through underlying medical comorbidities, post-surgery fibrosis, cardiac remodeling, or increased loading condition 3-8, 11-13 ). This study is different from other investigations examining the association between CHD and AF in that it does not focus on AF during subsequent years for a certain type of CHD or a specified age group, making this study unique, relevant, and informative 3-8, 11-13 ).…”

“…CHD patients are vulnerable to arrhythmia events, especially atrial fibrillation (AF) 3-6 ). Indeed, the relationship between CHD and AF occurrence is clear 3-8 ). Patients with CHD-complicated AF may have a higher risk of AF-related complications (stroke, heart failure, and bleeding) resulting in early death; hence, they deserve increased attention 3-8 ).…”

“…Indeed, the relationship between CHD and AF occurrence is clear 3-8 ). Patients with CHD-complicated AF may have a higher risk of AF-related complications (stroke, heart failure, and bleeding) resulting in early death; hence, they deserve increased attention 3-8 ). Although the association and the underlying mechanism have been explored previously, early studies primarily focused on the association between a certain type of CHD and concerned the risk of AF among CHD patients who were children and young adults 3-8 ).…”

“…Patients with CHD-complicated AF may have a higher risk of AF-related complications (stroke, heart failure, and bleeding) resulting in early death; hence, they deserve increased attention 3-8 ). Although the association and the underlying mechanism have been explored previously, early studies primarily focused on the association between a certain type of CHD and concerned the risk of AF among CHD patients who were children and young adults 3-8 ). To add to the existing literature on patients with CHD and AF from a clinical perspective, using National Health Insurance data, the authors conducted this observational-epidemiology study with propensity score matching analysis and multivariable Cox proportional hazards models to evaluate the risk of AF among CHD patients.…”