Atrial Fibrillation and the Renin-Angiotensin-Aldosterone System

Perlini, Stefano; Belluzzi, Fabio; Salinaro, Francesco; Musca, Francesco

doi:10.5772/53917

Cited by 2 publications

(2 citation statements)

References 150 publications

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“…12,13 AF is associated with the activation of the sympathetic nervous system, renin-angiotensin-aldosterone system, and impaired insulin resistance. [14][15][16] These factors can further promote endothelial dysfunction and result in micro-and macroarterial disease. The presence of systemic vascular disease and the haemodynamic perturbations of AF can augment the severity of one another in these often comorbid disease states.…”

Section: Af and Vascular Diseasementioning

confidence: 99%

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This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment

Zenger

Rizzi

Steinberg

et al. 2023

Arrhythm Electrophysiol Rev

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AF is an independent and strong predictor of long-term cognitive decline. However, the mechanism for this cognitive decline is difficult to define and likely multifactorial, leading to many different hypotheses. Examples include macro- or microvascular stroke events, biochemical changes to the blood–brain barrier related to anticoagulation, or hypo-hyperperfusion events. This review explores and discusses the hypothesis that AF contributes to cognitive decline and dementia through hypo-hyperperfusion events occurring during cardiac arrhythmias. We briefly explain several brain perfusion imaging techniques and further examine the novel findings associated with changes in brain perfusion in patients with AF. Finally, we discuss the implications and areas requiring more research to further understand and treat patients with cognitive decline related to AF.

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Section: Af and Vascular Diseasementioning

confidence: 99%

“…The presence of systemic vascular disease and the haemodynamic perturbations of AF can augment the severity of one another in these often comorbid disease states? [ 14 , 15 ]…”

Section: Af and Vascular Diseasementioning

confidence: 99%

This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment

Zenger

Rizzi

Steinberg

et al. 2023

Arrhythm Electrophysiol Rev

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News on angiotensin II and atrial fibrillation : from the molecular to the pathophysiological.

et al. 2021

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Introducción: la fibrilación auricular es la arritmia más prevalente en el mundo y acarrea elevadas cifras de morbilidad y mortalidad. Numerosos estudios han demostrado la participación del sistema renina angiotensina en la patogenia de la fibrilación auricular, y en varios de estos, se especula el mecanismo subyacente que involucra un proceso de remodelación del tejido auricular. Objetivo: exponer literatura relacionada con los mecanismos fisiopatológicos de la Fibrilación Auricular, su impacto en el riesgo cardiovascular, y aspectos relacionados entre angiotensina II y fibrilación auricular. Métodos: se llevó a cabo una revisión no sistemática de la literatura utilizando términos clave tales como “Atrial Fibrillation” y “Angiotensin II”, además de sinónimos, los cuales fueron combinados con los conectores “AND” y “OR”, tanto en inglés como en español, en las bases de datos PubMed, ScienceDirect, Embase, EBSCO, y MEDLINE. Resultados: la fibrosis atrial constituye una alteración estructural que propicia el mantenimiento de la Fibrilación Auricular, y la Angiotensina II contribuye en este proceso ampliamente mediante la estimulación de procesos inflamatorios, disminución en la actividad de colagenasa, aumento en la expresión de MAPK, y cambios en las propiedades electrofisiológicas cardíacas a través de la unión al receptor AT1. Conclusiones: conocer la fisiopatología de la fibrilación auricular a nivel molecular, permite dilucidar aún más el contexto y las posibles complicaciones de los pacientes afectados, facilitando la generación de hipótesis que contribuyan al diagnóstico oportuno, preciso y efectivo, el desarrollo de nuevas dianas terapéuticas, así como un mejor enfoque en el área clínica.

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Atrial Fibrillation and the Renin-Angiotensin-Aldosterone System

Cited by 2 publications

References 150 publications

This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment

This is Your Brain, and This is Your Brain on Atrial Fibrillation: The Roles of Cardiac Malperfusion Events and Vascular Dysfunction in Cognitive Impairment

News on angiotensin II and atrial fibrillation : from the molecular to the pathophysiological.

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