Atrial fibrillation and stroke in adult patients with atrial septal defect and the long-term effect of closure

Abstract

Patients with ASD had a higher risk of first-time AF after closure than the comparison cohort. There was no effect of closure on the use of AF-related medicine in patients with prevalent AF.

Risk of Atrial Fibrillation in Patients with Congenital Heart Disease: Results of a Propensity Score-Matched, Nationwide Cohort Study

“…CHD patients are vulnerable to arrhythmia events, especially atrial fibrillation (AF) 3-6 ). Indeed, the relationship between CHD and AF occurrence is clear 3-8 ).…”

“…CHD patients are vulnerable to arrhythmia events, especially atrial fibrillation (AF) 3-6 ). Indeed, the relationship between CHD and AF occurrence is clear 3-8 ). Patients with CHD-complicated AF may have a higher risk of AF-related complications (stroke, heart failure, and bleeding) resulting in early death; hence, they deserve increased attention 3-8 ).…”

Atrial fibrillation and stroke after atrial septal defect closure. Is earlier closure warranted?

“…Nyboe et al 9 also demonstrate that ASD is associated with significant morbidity. Patients with ASD had a twofold higher risk of stroke as compared with an age-matched and gender-matched comparison cohort, either closed or not.…”

“…Nyboe et al 9 present data on the impact of ASD closure on the risk of AF and stroke by using the Danish National Patient Registry. They identified 1168 adult patients who were diagnosed with isolated ASD from 1977 to 2009.…”

“…To evaluate the effect of ASD closure on the burden of AF in patients with pre-existing AF, the authors used a unique approach 9. They focused on the use of antiarrhythmic drug therapy and anticoagulation by using the Danish National Prescription Registry (excluding patients with mechanical heart valve or deep vein thrombosis).…”