Atrial Fibrillation and Primary Aldosteronism: A Meta-Analysis

Abstract

Primary Aldosteronism (PA) is a condition notoriously causing serious damage to cardiovascular system. It is reported that regardless of high blood pressure high level of long exposition of aldosterone determine target organ damage and predisposes to atrial fibrillation. Arterial hypertension is a major risk factor for atrial fibrillation (AF) and between 50% and 90% of AF patients have hypertension [22]. PA patients were reported to have a highly significant 12-fold higher risk of AF than essential hypertensive patients [23]. We searched on PubMed, Cochrane library and Web of science for clinical studies on the prevalence of arrhythmias such as atrial fibrillation and cerebrovascular events among PA patients. In this meta-analysis we want to evaluate the risk of AF associated to hyperaldosteronism because there are results not always clear that deserve a further investigation. The results show us that AF is a prevalence risk associated with PA vs EH. As for the stroke events, the results show that AF as prevalence is not associated with PA vs EH.