Atrial fibrillation and inflammation

Özaydın, Mehmet

doi:10.4330/wjc.v2.i8.243

Cited by 31 publications

(25 citation statements)

References 88 publications

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“…responsible for the development of atrial fibrillation [1,3,17]. Even the atrial pathoanatomy in lone atrial fibrillation showed inflammatory infiltration, muscle cell necrosis and fibrosis [1,17]. Modern research has confirmed that chronic inflammation has arrhythmogenic effect giving rise to the development of AF in susceptible populations.…”

Section: Discussionmentioning

confidence: 97%

“…Inflammation is closely associated to atrial fibrillation [6] and may be the important medium which links atrial fibrillation with known risk factors (such as high blood pressure and obesity, etc.) responsible for the development of atrial fibrillation [1,3,17]. Even the atrial pathoanatomy in lone atrial fibrillation showed inflammatory infiltration, muscle cell necrosis and fibrosis [1,17].…”

Section: Discussionmentioning

confidence: 99%

“…It has become one of the leading causes for hospitalized patients with AF because AF may induce stroke, heart failure and increase case fatality [1,2,4]. Unfortunately, its fundamental pathological mechanisms are not fully clear.…”

Section: Introductionmentioning

confidence: 99%

“…Atrial fibrillation (AF) is the most common cardiac arrhythmia and increases in prevalence with aging [1][2][3]. It has become one of the leading causes for hospitalized patients with AF because AF may induce stroke, heart failure and increase case fatality [1,2,4].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Analysis of Association of Cystatin C and Atrial Fibrillation

Liu

Sui

2014

Russ J Cardiol

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Some studies have disclosed atrial fibrillation (AF) is associated with inflammation. Cystatin C is not only inflammatory markers but also an independent predictor of cardiovascular events. Aim. We sought to investigate the relationship between serum levels of cystatin C and the occurrence and development of AF. Material and methods. 235 paroxysmal and persistent AF (AF1 group) and 254 permanent AF (AF2 group) patients in AF group and 221 healthy people in control group were prospectively measured for cystatin C, other inflammatory markers, biochemical indicators, left atrial diameter (LAD), left ventricular diameter (LVD) and left ventricular ejection fraction (LVEF). Results.(1) Compared with control and AF1 groups, AF2 group had higher values of cystatin C, high sensitivity C reactive protein (hsCRP), LAD and LVD whereas lower values of LVEF (P<0.05). (2) After adjust for age, gender and body mass index (BMI), correlation analysis showed that serum level of cysta tin C was closely related to hsCRP, LAD, systolic blood pressure (SBP) and creatinine, the correlation coefficient were respectively 0, 614, 0,520, 0,463 and 0,538 (all P<0,01), but negatively associated with LVEF (r= -0,356, P=0,012) in AF group. (3) Multivariate regression analysis showed the hsCRP, cystatin C, LAD and LVEF entered finally into the regression equation (cystatin C, OR: 3.25, 95%CI: 1.05-10.17, P=0,008). Conclusion. The serum levels of cystatin C has significant correlation with AF, which indicates cystatin C may play an important role in the process of AF development. КЛИНИЧЕСКИЙ АНАЛИЗ АССОЦИАЦИИ ЦИСТАТИНА С И ФИБРИЛЛЯЦИИ ПРЕДСЕРДИЙPing Liu, Shujian Sui, Dongling Xu В некоторых исследованиях было выявлено, что фибрилляция предсердий (ФП) связана с воспалением. Цистатин С является не только воспалительным маркером, но и независимым предиктором сердечно-сосудистых событий. Цель. Мы попытались выяснить отношения между уровнем цистатина С в сыворотке крови и возникновением и развитием ФП. Материал и методы. 235 пациента с пароксизмальной и персистирующей ФП (ФП1 группа), 254 пациента с постоянной ФП (ФП2 группа) и 221 здоровых людей в контрольной группе были под наблюдением для измерения цистатина С, других воспалительных маркеров, биохимических показателей, диаметра левого предсердия (LAD), диаметра левого желудочка (LVD) и фракции выброса левого желудочка (ФВ ЛЖ). Результаты. (1) В сравнении с группой контроля, группы ФП1 и ФП2 имели более высокие значения уровня цистатина С, высокую чувствительность C реактивного белка (hsCRP), LAD и LVD в тоже время -низкие значения ФВ ЛЖ (P<0,05). (2) После ранжирования по возрасту, полу и индексу массы тела (ИМТ), корреляционный анализ показал, что сывороточный уровень цистатина С тесно связан с hsCRP LAD, систолическим артериальным давле-нием (САД) и креатинином, коэффициенты корреляции были, соответст-венно, 0,614, 0,520, 0,463 and 0,538 (P<0,01), но отрицательно ассоцииро-ваны с ФВ ЛЖ (r= -0,356, P=0,012) в группе с ФП. (3) Многофакторный рег-рессионный анализ показал, что hsCRP, цистатин С, ...

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Analysis of Association of Cystatin C and Atrial Fibrillation

Liu

Sui

2014

Russ J Cardiol

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical Analysis of Association of Cystatin C and Atrial Fibrillation

Liu

Sui

2014

Russ J Cardiol

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Some studies have disclosed atrial fibrillation (AF) is associated with inflammation. Cystatin C is not only inflammatory markers but also an independent predictor of cardiovascular events. Aim. We sought to investigate the relationship between serum levels of cystatin C and the occurrence and development of AF. Material and methods. 134 paroxysmal and persistent AF (AF1 group) and 121 permanent AF (AF2 group) patients in AF group and 154 healthy people in control group were prospectively measured for cystatin C, other inflammatory markers, biochemical indicators, left atrial diameter (LAD), left ventricular diameter (LVD) and left ventricular ejection fraction (LVEF). Results.(1) Compared with control and AF1 groups, AF2 group had higher values of cystatin C, high sensitivity C reactive protein (hsCRP), LAD and LVD whereas lower values of LVEF (P<0.05). (2) After adjust for age, gender and body mass index (BMI), correlation analysis showed that serum level of cystatin C was closely related to hsCRP, LAD, systolic blood pressure (SBP) and creatinine, the correlation coefficient were respectively 0.658, 0.502, 0.475 and 0.530 (P<0.01), but negatively associated with LVEF (P=0.011) in AF group. (3) Multivariate regression analysis showed the hsCRP, cystatin C, LAD and LVEF entered finally into the regression equation (cystatin C, OR: 3.41, 95%CI: 1.09-11.08, P=0.009). Conclusion. The serum levels of cystatin C has significant correlation with AF, which indicates cystatin C may play an important role in the process of AF development. КЛИНИЧЕСКИЙ АНАЛИЗ АССОЦИАЦИИ ЦИСТАТИНА С И ФИБРИЛЛЯЦИИ ПРЕДСЕРДИЙPing Liu, Shujian Sui, Dongling Xu В некоторых исследованиях было выявлено, что фибрилляция предсердий (ФП) связана с воспалением. Цистатин С является не только воспалительным маркером, но и независимым предиктором сердечно-сосудистых событий. Цель. Мы попытались выяснить отношения между уровнем цистатина С в сыворотке крови и возникновением и развитием ФП. Материал и методы. 134 пациента с пароксизмальной и персистирующей ФП (ФП1 группа), 121 пациент с постоянной ФП (ФП2 группа) и 154 здоровых людей в контрольной группе были под наблюдением для измерения цистатина С, других воспалительных маркеров, биохимических показателей, диаметра левого предсердия (LAD), диаметра левого желудочка (LVD) и фракции выброса левого желудочка (ФВ ЛЖ). Результаты. (1) В сравнении с группой контроля, группы ФП1 и ФП2 имели более высокие значения уровня цистатина С, высокую чувствительность C реактивного белка (hsCRP), LAD и LVDб в тоже время -низкие значения ФВ ЛЖ (P<0,05). (2) После ранжирования по возрасту, полу и индексу массы тела (ИМТ), корреляционный анализ показал, что сывороточный уровень цистатина С тесно связан с hsCRP LAD, систолическим артериальным давлением (САД) и креатинином, коэффициенты корреляции были, соответственно, 0.658, 0.502, 0.475 и 0.530 (P<0.01), но отрицательно ассоциированы с ФВ ЛЖ (Р=0,011) в группе с ФП. (3) Многофакторный регрессионный анализ показал, что hsCRP, цистатин С, LAD и ФВ ЛЖ в конечном счете входя...

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Impact of Intensive Glycemic Control on the Incidence of Atrial Fibrillation and Associated Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus (from the Action to Control Cardiovascular Risk in Diabetes Study)

Fatemi

Yuriditsky

Tsioufis

et al. 2014

The American Journal of Cardiology

146

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Atrial fibrillation (AF) is prevalent among individuals with type 2 diabetes mellitus (DM), and is associated with markers of poor glycemic control; however the impact of glycemic control on incident AF and outcomes is unknown. We sought to prospectively evaluate if intensive glycemic control in individuals with DM impacts incident AF, and to evaluate morbidity and mortality among individuals with DM and incident AF. We studied 10,082 individuals with DM from the ACCORD cohort in a randomized, double-blind fashion. Participants were randomized to an intensive therapeutic strategy targeting a glycated hemoglobin level of <6.0%, or a standard strategy targeting a glycated hemoglobin of 7.0-7.9%. Incident AF occurred in 159 patients (1.58%) over the follow-up period at a rate of 5.9/1,000 person-years in the intensive-therapy group, and a rate of 6.37/1,000 person-years in the standard-therapy group (p=0.52). In a multivariate model, predictors of incident AF were age, weight, diastolic blood pressure, heart rate, and heart failure history. Patients with DM and new-onset AF had a HR of 2.65 for all-cause mortality (95% CI 1.8-3.86, p<0.0001), HR of 2.1 for myocardial infarction (95% CI 1.33-3.31, p=0.0015), and HR of 3.80 for development of heart failure (95% CI 2.48-5.84, p<0.0001). In conclusion, intensive glycemic control did not impact rate of new-onset AF. Patients with DM and incident AF had an increased risk for morbidity and mortality as compared to those without AF.

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Atrial fibrillation and inflammation

Cited by 31 publications

References 88 publications

Clinical Analysis of Association of Cystatin C and Atrial Fibrillation

Clinical Analysis of Association of Cystatin C and Atrial Fibrillation

Clinical Analysis of Association of Cystatin C and Atrial Fibrillation

Impact of Intensive Glycemic Control on the Incidence of Atrial Fibrillation and Associated Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus (from the Action to Control Cardiovascular Risk in Diabetes Study)

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