Atrial fibrillation and cognitive disorders: An overview on possible correlation

Puccio, Danilo; Vizzini, MC; Baiamonte, Valentina; Lunetta, Monica; Evola, Salvatore; Galassi, Alfredo R.; Novo, Giuseppina

doi:10.1016/j.mad.2020.111326

Cited by 1 publication

(4 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nonetheless, the impact of AF-type on longitudinal cognition was present in multivariate models suggesting some genuine effect of AF-type on cognition. Although AF and cognitive drop are likely to share one or more underlying pathogenic mechanisms, their possible pathophysiological aspects are still not fully understood ( 1 , 26 ). Therefore, future studies with a control group are needed to explore the interplay between AF-type and other cardiovascular risk factors and comorbidities in relation to cognitive drop over time.…”

Section: Discussionmentioning

confidence: 99%

“…Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting people of all ages ( 1 , 2 ). As its incidence and prevalence increase with age, it is estimated that about 17.9 million adults aged over 55 years in 2060 will experience AF in the European Union ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

“…First, studies differ in methodological aspects such as sample size, duration of follow-up periods and statistical methods, as well as with respect to the assessments of cognitive performance ( 1 , 13 ). Second, not all studies systematically adjusted for known confounders in multivariable models since AF and cognitive decline share multiple risk factors and comorbidities ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

“…Finally, it has been shown that next to increasing age, the prevalence of heart failure, hypertension, diabetes, coronary artery, and cerebrovascular diseases increases with progression from paroxysmal to non-paroxysmal (persistent or permanent) AF subtype ( 15 ). Although the progression of AF and the development of cognitive decline share common risk factors ( 1 ), the association of AF and its subtypes with change in cognitive function as well as the possible effects of comorbidities have not been investigated. Additionally, it is unknown if non-paroxysmal AF, characterized as persistent or permanent and with increased symptom severity, is more involved in change of cognitive function than paroxysmal AF ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mid-term changes in cognitive functions in patients with atrial fibrillation: a longitudinal analysis of the Swiss-AF cohort

Wueest

Zuber

Coslovsky

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundLongitudinal association studies of atrial fibrillation (AF) and cognitive functions have shown an unclear role of AF-type and often differ in methodological aspects. We therefore aim to investigate longitudinal changes in cognitive functions in association with AF-type (non-paroxysmal vs. paroxysmal) and comorbidities in the Swiss-AF cohort.MethodsSeven cognitive measures were administered up to five times between 2014 and 2022. Age-education standardized scores were calculated and association between longitudinal change in scores and baseline AF-type investigated using linear mixed-effects models. Associations between AF-type and time to cognitive drop, an observed score of at least one standard deviation below individual's age-education standardized cognitive scores at baseline, were studied using Cox proportional hazard models of each cognitive test, censoring patients at their last measurement. Models were adjusted for baseline covariates.Results2,415 AF patients (mean age 73.2 years; 1,080 paroxysmal, 1,335 non-paroxysmal AF) participated in this Swiss multicenter prospective cohort study. Mean cognitive scores increased longitudinally (median follow-up 3.97 years). Non-paroxysmal AF patients showed smaller longitudinal increases in Digit Symbol Substitution Test (DSST), Cognitive Construct Score (CoCo)and Trail Making Test part B (TMT-B) scores vs. paroxysmal AF patients. Diabetes, history of stroke/TIA and depression were associated with worse performance on all cognitive tests. No differences in time to cognitive drop were observed between AF-types in any cognitive test.ConclusionThis study indicated preserved cognitive functioning in AF patients, best explained by practice effects. Smaller practice effects were found in non-paroxysmal AF patients in the DSST, TMT-B and the CoCo and could indicate a marker of subtle cognitive decline. As diabetes, history of stroke/TIA and depression—but not AF-type—were associated with cognitive drop, more attention should be given to risk factors and underlying mechanisms of AF.

show abstract

Section: Discussionmentioning

confidence: 99%