Atrial fibrillation after vaccination for COVID-19: analysis of the vaccine adverse event reporting system

Kumar, Ashish; Shariff, Mariam; Bhat, Vivek; DeSimone, Christopher P.; Deshmukh, Abhishek

doi:10.1007/s10840-022-01263-4

Cited by 13 publications

(13 citation statements)

References 5 publications

(4 reference statements)

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“…Other studies have investigated the incidence of cardiovascular adverse events following the COVID-19 vaccination in the general population, using databases such as Vigibase [8], VAERS [9] or IEMS [10]. To our knowledge, our present study would be the second one to specifically investigate the rates of cardiovascular adverse events leading to emergency room visits and hospitalizations following COVID-19 vaccination.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Adverse Events after COVID-19 Vaccination

Morales

Maroo

Kewan

et al. 2023

Int J Anaesth Crit Care

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Section: Discussionmentioning

confidence: 99%

Cardiovascular Adverse Events after COVID-19 Vaccination

Morales

Maroo

Kewan

et al. 2023

Int J Anaesth Crit Care

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“…Some cases of cardiac arrhythmias, including non-sustained ventricular tachycardia [ 86 ], atrial fibrillation [ 87 ], high-degree atrioventricular block [ 88 ], have also been described without previous clinical signs of myocarditis; however, these observations were made without definitely ruling out any myocardial injury by using cardiac MRI. A large study enrolling 7934 high school students after mRNA vaccination and ECG screening revealed that the second dose of anti-SARS-CoV-2 vaccination with a mRNA-based vaccine can have significant cardiac adverse effects.…”

Section: Covid-19 Vaccination-associated Arrhythmiasmentioning

confidence: 99%

Cardiac Arrhythmias in Post-COVID Syndrome: Prevalence, Pathology, Diagnosis, and Treatment

Huseynov

Akın

Duerschmied

et al. 2023

Viruses

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An increase in post-COVID patients with late sequelae of acute COVID-19 infection is emerging as an ongoing challenge for physicians and healthcare professionals. Since the beginning of the pandemic, it has rapidly become evident that the acute infection is not limited to the respiratory tract but that several organs, including the cardiovascular system, can be affected. Moreover, in a significant proportion of patients (ranging from about 10 to up to 50%) with former COVID-19, cardiopulmonary symptoms such as dyspnea, palpitations, restricted physical capacity, and cardiac arrhythmias can persist weeks and months after the acute SARS-CoV-2 infection. The spectrum of COVID-19-associated arrhythmias is rather wide, most likely due to various pathomechanisms. In this article, the prevalence of cardiac arrhythmias and underlying pathologies are reviewed, including direct myocardial injury and abnormal consequences with an impact on cardiac electric instability. The hyperinflammatory reaction of the host immune system is specifically considered. Moreover, several distinct rhythm disorders occurring in post-COVID patients are discussed with regard to their clinical management.

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“…New-onset A-fib is most commonly associated with Pfizer followed by Moderna and Johnson and Johnson vaccines [ 99 ]. According to Vaccine Adverse Reporting System (VAERS), after administration of 532 million doses of vaccine, the number of total and new-onset A-fib cases reported is 2611 and 315, respectively [ 99 ]. The average incidence of A-fib cases is approximately 5 per 1 million doses vaccine administered [ 99 ].…”

Section: Main Textmentioning

confidence: 99%

“…According to Vaccine Adverse Reporting System (VAERS), after administration of 532 million doses of vaccine, the number of total and new-onset A-fib cases reported is 2611 and 315, respectively [ 99 ]. The average incidence of A-fib cases is approximately 5 per 1 million doses vaccine administered [ 99 ]. Another meta-analysis study indicated that the incidence of A-fib post COVID-19 vaccination is around 1–76 per 10,000 vaccine doses administered [ 100 ].…”

Section: Main Textmentioning

confidence: 99%

COVID-19 HEART unveiling as atrial fibrillation: pathophysiology, management and future directions for research

2023

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Background COVID-19 infections are known to cause numerous systemic complications including cardiovascular disorders. In this regard, clinicians recently noticed that patients recovering from COVID-19 infections presented with diverse set of cardiovascular disorders in addition to those admitted to ICU (intensive care unit). COVID-19 heart has multifaceted presentation ranging from dysrhythmias, myocarditis, stroke, coronary artery disease, thromboembolism to heart failure. Atrial fibrillation is the most common cardiac arrhythmia among COVID-19 patients. In the background section, we briefly discussed epidemiology and spectrum of cardiac arrhythmias in COVID-19 patients. Main body In this state-of-the-art review we present here, we present the information regarding COVID-19-induced A-fib in sections, namely mechanism of action, clinical presentation, diagnosis and treatment. Unfortunately, its occurrence significantly increases the mortality and morbidity with a potential risk of complications such as cardiac arrest and sudden death. We included separate sections on complications including thromboembolism and ventricular arrhythmias. Since its mechanism is currently a gray area, we included a separate section on basic science research studies that are warranted in the future to comprehend its underlying pathogenic mechanisms. Conclusions Taken together, this review builds upon the current literature of COVID-19-induced A-fib, including pathophysiology, clinical presentation, treatment and complications. Furthermore, it provides recommendations for future research moving forward that can open avenues for developing novel remedies that can prevent as well as hasten clinical recovery of atrial fibrillation in COVID-19 patients.

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Atrial fibrillation after vaccination for COVID-19: analysis of the vaccine adverse event reporting system

Cited by 13 publications

References 5 publications

Cardiovascular Adverse Events after COVID-19 Vaccination

Cardiovascular Adverse Events after COVID-19 Vaccination

Cardiac Arrhythmias in Post-COVID Syndrome: Prevalence, Pathology, Diagnosis, and Treatment

COVID-19 HEART unveiling as atrial fibrillation: pathophysiology, management and future directions for research

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