Atrial fibrillation after coronary artery bypass grafting is associated with sympathetic activation

Kalman, Jonathan M.; Munawar, Muhammad; Howes, L. G.; Louis, William J.; Buxton, B.; Gutteridge, Geoffrey A; Tonkin, Andrew

doi:10.1016/0003-4975(95)00718-0

Cited by 319 publications

(217 citation statements)

References 14 publications

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“…Catecholamines and 5-HT have been proposed to initiate AF (8,9). The relevance of these in vitro arrhythmias is corroborated by the clinical finding that high sympathetic nervous system activity during and after cardiac surgery causes premature beats and transient postoperative AF in approximately one-third of patients (10).…”

Section: Fig 1 Bone Cells Express Avprs Immunofluorescence Microgrmentioning

confidence: 92%

“…Arrhythmias of this sort may trigger extrasystoles that could lead to paroxysmal AF or transient postoperative AF, the latter of which is often prevented by treatment with βAR blockers (10). In contrast, βAR blockers neither affect the incidence of chronic AF (33) nor convert AF into SR (34) in patients with advanced heart failure, inconsistent with a contribution of endogenous catecholamines.…”

Section: Kn-93 Reduces Ne-evoked Increases Of I Cal In Patients Withmentioning

confidence: 99%

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Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation

Christ

Rozmaritsa²,

Engel³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Fig. 1. Bone cells express Avprs. Immunofluorescence micrographs (A) and Western immunoblotting (B)show the expression of Avpr1α in osteoblasts and osteoclasts, and as a function of osteoblast (mineralization) and osteoclast (with Rankl) differentiation. The expression of Avp (ligand) and Avpr1α (receptor) in osteoblasts is regulated by 17β-estradiol, as determined by quantitative PCR (C) and Western immunoblotting (D). (Magnification: A, 63×.) Because Avp is a small peptide, its precursor neurophysin II is measured. Statistics: Student t test, P values shown compared with 0 h. Stimulation of Erk phosphorylation (p-Erk) as a function of total Erk (t-Erk) by Avp (10 −8 M) in osteoclast precursors (preosteoclasts), osteoclasts (OC), and osteoblasts establishes functionality of the Avpr1α in the presence or absence of the receptor inhibitor SR49059 (10 −8 M) (E). Western immunoblotting showing the expression of Avpr2 in preosteoclasts, OCs (F), and osteoblasts (G) isolated from Avpr1α −/− mice, as well as in MC3T3.E1 osteoblast precursors (G). Functionality of Avpr2 was confirmed by the demonstration that cells from Avpr1α −/− mice remained responsive to AVP in reducing the expression of osteoblast differentiation genes, namely Runx2, Osx, Bsp, Atf4, Opn, and Osteocalcin (quantitative PCR, P values shown) (H). Only relevant bands from Western blots are shown, with gaps introduced where empty lanes are excised to conserve space.

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Section: Fig 1 Bone Cells Express Avprs Immunofluorescence Microgrmentioning

confidence: 92%

Section: Kn-93 Reduces Ne-evoked Increases Of I Cal In Patients Withmentioning

confidence: 99%

Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation

Christ

Rozmaritsa²,

Engel³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…Moreover, the management of these arrhythmias has been shown to significantly extend the length of hospitalization. 4,5 The Maze procedure has evolved into the gold standard of treatment for medically refractory atrial fibrillation (AF) during the past decade. The atrial incisions of the procedure are designed to block potential macroreentrant pathways and narrow the atrial tissue to block propagation of microreentrant wavelets.…”

mentioning

confidence: 99%

Atrial Tachyarrhythmias After the Maze Procedure

Ishii¹,

Gleva²,

Gamache³

et al. 2004

Circulation

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“…The incidence of POAF has increased continuously over the past decades and it's believed to be either due to aging of the population undergoing heart surgery or deployment of more sensitive methods of surveillance of AF, such as telemetric monitoring. 11,12 According to MEDLINE database reports published between 2010 and June 2014 by using the keyword atrial fibrillation, coronary artery bypass grafting. The author found 10 to 65 % of patients developing AF post operatively depending on patient's profile, type of surgery, method of arrhythmia surveillance and definition of arrhythmia.…”

Section: Discussionmentioning

confidence: 99%

Atrial Fibrillation; To Determine the Frequency and Its Predisposing Factors in Patients After Coronary Artery Bypass Grafting.

Riaz

2017

TPMJ

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ABSTRACT… Introduction: Atrial Fibrillation (AF) is one of the most common arrhythmia after coronary artery bypass grafting (CABG). Many risk factors have been identified for the development of postoperative AF with varied level of evidence. AF is associated with increased risk of morbidity and mortality causing prolong hospital stay and utilizing more resources. Our study was aimed to identify high risk population for developing post-operative AF and to draw recommendations for its prevention. Objectives: Our objective was to determine the frequency of Atrial Fibrillation (AF) and its predisposing factors in patients after Coronary Artery Bypass Grafting (CABG). Setting: The study was conducted at Cardiac Surgery Department / Faisalabad Institute of Cardiology, Faisalabad. Duration of Study: 15-12-2014 to 14-07-2015. Study Design: Cross sectional study. Results: The result showed that out of 130 patients undergoing CABG surgery, 104 (80.3%) male and 26 (19.7%) females, 9(7%) patients suffered AF in post-operative phase. A significant association was found between postoperative AF and advanced age (p = 0.011), obesity (p = 0.028), low EF (p = 0.000), and post-operative use of β-blocker (p = 0.007). Significant difference was found between postoperative AF and days stayed in hospital (p = 0.000) and magnesium level at first day (p = 0.038). On the other hand there was no significant relationship found between AF and prolongs cross clamp and bypass time. Conclusion: Advance age, obesity, congestive heart failure, low ejection fraction and withdrawal from beta blockers in post-operative period have been identified as a significant risk factors for the development of post-operative atrial fibrillation. Key words:Atrial Fibrillation, Coronary Artery Bypass Grafting, Postoperative Arrhythmia. Article Citation: Riaz R, Ahmad N, Abbas S. Atrial fibrillation; To determine the frequency and its predisposing factors in patients after coronary artery bypass grafting.

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Atrial fibrillation after coronary artery bypass grafting is associated with sympathetic activation

Cited by 319 publications

References 14 publications

Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation

Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation

Atrial Tachyarrhythmias After the Maze Procedure

Atrial Fibrillation; To Determine the Frequency and Its Predisposing Factors in Patients After Coronary Artery Bypass Grafting.

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