Atrial conduction abnormalities in patients with systemic progressive sclerosis

Mizuno, Reiko; Fujimoto, Shinichi; Nakano, Hiroshi; Nakajima, Tamio; Kimura, Asako; Nakagawa, Yoshihito; Dohi, Kazuhiro

doi:10.1093/oxfordjournals.eurheartj.a015211

Cited by 24 publications

(19 citation statements)

References 22 publications

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“…Atrial disruption caused by fibrosis has been suggested as the mechanism underlying IAB. Fibrosis was associated with both ischemic heart disease 29 and nonischemic heart disease, including systemic sclerosis, 29,30 dilated cardiomyopathy, 31 hypertrophic cardiomyopathy, 31 lymphoma, 32 and increased atrial strain because of valvular heart disease. 33 Histological studies demonstrated that right atrial tissue (including BB tissue) of patients with IAB shows apparent fibrosis, 34,35 though fibrosis of BB alone has not been described.…”

Section: Bb Blockmentioning

confidence: 99%

Bachmann’s Bundle

Campenhout

Yaksh

Kik

et al. 2013

Circ: Arrhythmia and Electrophysiology

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Section: Bb Blockmentioning

confidence: 99%

Bachmann’s Bundle

Campenhout

Yaksh

Kik

et al. 2013

Circ: Arrhythmia and Electrophysiology

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“…27) In our study of patients with PAF, the duration of PA-TMF was inversely correlated with LAA-FV, suggesting that PA-TMF reflects LA electrical and structural remodeling, resulting in prolonged inter-atrial conduction time, thereby enabling the estimation of LAA-FV in patients with PAF. The geometrical distance between the two atria may also be an important determining factor for inter-atrial conduction time.…”

Section: Discussionmentioning

confidence: 59%

“…26) Mizuno, et al previously reported that inter-atrial conduction time determined using TTE and ECG was delayed in patients with progressive systemic sclerosis. 27) They showed that the time interval between initiation of the P-wave and onset and the peak of the A-wave Each parameter was compared with LAA-FV using single regression analysis. A probability (P) value < 0.05 was considered statistically significant and marked by an asterisk.…”

Section: Discussionmentioning

confidence: 99%

Left Atrial Remodeling Assessed by Transthoracic Echocardiography Predicts Left Atrial Appendage Flow Velocity in Patients With Paroxysmal Atrial Fibrillation

et al. 2016

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SummaryAtrial fibrillation (AF) is associated with an increased risk of stroke and other thromboembolic events. Left atrial (LA) thrombus formation is closely related to LA dysfunction, particularly to decreased LA appendage flow velocity (LAA-FV) in patients with AF. We estimated LAA-FV using parameters noninvasively obtained by transthoracic echocardiography (TTE) in patients with paroxysmal AF.Echocardiographic and clinical parameters were assessed in 190 patients with nonvalvular paroxysmal AF showing sinus heart rhythm during transesophageal echocardiography (TEE) and TTE.LAA-FV (60 ± 22 cm/s) significantly correlated with the time interval between the initiation of the P-wave on ECG and that of the A-wave of transmitral flow on TTE (PA-TMF, correlation coefficient, −0.32; P < 0.001), LA dimension (LAD, −0.31; P < 0.001), septal a' velocity of tissue Doppler imaging (TDI, 0.35; P < 0.001), E/e' ratio (−0.28, P < 0.001), E velocity of transmitral flow (−0.20, P = 0.008), E/A ratio of transmitral flow (−0.18, P = 0.02), CHA2DS2-VASc score (−0.15, P = 0.04), and BNP plasma level (−0.32, P = 0.002). Multivariate analysis revealed that PA-TMF (standardized partial regression coefficient, −0.17; P = 0.03), a' velocity (0.24, P = 0.004), and LAD (−0.20, P = 0.01) were independent predictors of LAA-FV (multiple correlation coefficient R, 0.44; P < 0.001).Parameters of atrial remodeling, ie, decreased a' velocity, increased LAD, and PA-TMF during sinus rhythm may be useful predictors of LA blood stasis in patients with nonvalvular PAF. LAA-FV can be estimated using these TTE parameters instead of TEE. (Int Heart J 2016; 57: 177-182)

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“…This method can be used to predict paroxysmal AF. The distance between the two atria is a significant determinative factor for atrial conduction, and inter-nodal pathways may play a major role in inter-AEMD [20]. Previous studies demonstrated that AEMD durations were significantly prolonged in patients with paroxysmal AF [4,19].…”

Section: Discussionmentioning

confidence: 99%

“…The results of each question were totalled to measure generalised anxiety, with higher scores linked to greater anxiety (range 0-56). Anxiety severity was classified as mild (HAM-A: 0-17), mild to moderate (HAM-A: [18][19][20][21][22][23][24], and moderate to severe (HAM-A: 25-30).…”

Section: Study Populationmentioning

confidence: 99%

Atrial electromechanical delay analysed by tissue Doppler echocardiography is prolonged in patients with generalised anxiety disorders

Öksüz¹,

Yarlıoğlueş²,

Öztürk³

et al. 2017

Kardiol Pol

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A b s t r a c tBackground: It has been shown that psychological status is associated with the likelihood of atrial fibrillation (AF). Prolongation of the duration of atrial electromechanical delay (AEMD) is known to be a precursor for AF development.Aim: Therefore, we aimed to evaluate AEMD in patients with anxiety disorder. Methods:In this prospective study, a total of 82 anxiety disorder and 80 healthy subjects were enrolled. Symptoms of anxiety were evaluated by using the Hamilton Anxiety Rating Scale (HAM-A). P-wave dispersion (PWD) was measured on a 12-lead electrocardiogram. Both intra-and inter-AEMD were measured with tissue Doppler imaging. Results:Basal characteristics were similar between the two groups. PWD, inter-and right intra-AEMD were significantly prolonged in patients with anxiety disorders, compared to the control group (p < 0.05). In the correlation analysis, HAM-A was significantly and moderately correlated with right intra-and inter-AEMD, and PWD. Conclusions:Patients suffering from anxiety disorders are characterised by prolonged AEMD, which can provide significant contributions to evaluate the risk for AF development in this group.

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Atrial conduction abnormalities in patients with systemic progressive sclerosis

Cited by 24 publications

References 22 publications

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Left Atrial Remodeling Assessed by Transthoracic Echocardiography Predicts Left Atrial Appendage Flow Velocity in Patients With Paroxysmal Atrial Fibrillation

Atrial electromechanical delay analysed by tissue Doppler echocardiography is prolonged in patients with generalised anxiety disorders

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