Atrazine-induced environmental nephrosis was mitigated by lycopene via modulating nuclear xenobiotic receptors-mediated response

Xia, Jun; Lin, Jianhua; Li, Xue-Nan; Zhang, Cong; Li, Nan; Du, Zheng-Hai; Li, Yanhua; Li, Jinlong

doi:10.1016/j.jnutbio.2017.09.006

Cited by 35 publications

(25 citation statements)

References 89 publications

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“…Lye, a type of carotenoid, is currently a popular food ingredient. Many articles have reported that Lye can inhibit inflammation and prevent spermatogenic disorders and nephrotoxicity 17,22‐26 . Additionally, in the daily diet, a large part of Lye comes from tomatoes, watermelons, pink grapefruit and other red vegetables or fruits 38,39 .…”

Section: Discussionmentioning

confidence: 99%

“… 13 In recent years, interest in Lye has increased rapidly, because the studies have shown that carotenoids have certain beneficial effects on human health and diseases, such as cardiovascular protection, 16 inhibiting the proliferation of malignant tumours such as prostate cancer and breast cancer 17‐19 . It had also been reported that Lye could not only play an anti‐inflammatory role in the animal models, but also can prevent the spermatogenic disorders and nephrotoxicity 20‐24 . The mechanism involved may include the Nrf2 pathway that gets regulated to exert an anti‐inflammatory and antioxidant effect 25 .…”

Section: Introductionmentioning

confidence: 99%

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Lycopene inhibits IL‐1β‐induced inflammation in mouse chondrocytes and mediates murine osteoarthritis

Zhan

Yan

Kong

et al. 2021

J Cellular Molecular Medi

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Osteoarthritis (OA) is a common chronic degenerative condition in the elderly, in which inflammation plays a key role in disease pathology. Lycopene (Lye), a member of the carotenoid family, has been reported to have anti‐inflammatory effects. The purpose of this study was to investigate the effect of Lye on the inflammation of chondrocytes and the mouse OA model. Chondrocytes were treated with interleukin (IL)‐1β, and the mouse OA model was induced by the surgical destabilization of the medial meniscus (DMM). The results showed that Lye could inhibit the expression of inflammatory factors and alleviate the degradation of extracellular matrix (ECM). Additionally, Lye could activate the Nrf2/HO‐1 pathway and reverse the activations of NF‐κB and STAT3 signal pathway induced by IL‐1β, suggesting that its anti‐inflammatory effect may be mediated via these pathways. The animal experiments showed that Lye could decrease the Osteoarthritis Research Society International (OARSI) scores of the knee, indicating that it could inhibit the occurrence and development of OA in mouse. Overall, our results indicated that Lye might be used as a novel drug for OA treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lycopene inhibits IL‐1β‐induced inflammation in mouse chondrocytes and mediates murine osteoarthritis

Zhan

Yan

Kong

et al. 2021

J Cellular Molecular Medi

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“…A large number of organophosphates are also PXR activators albeit often in a species-dependent manner [ 214 ]. A prototypical triazine compound, atrazine, strongly induced CYP2B6 expression without any apparent human CAR activation [ 44 ] or EGF receptor binding [ 100 ], a finding that may be explained by increased expression of CAR [ 215 ] and contribution to CYP2B6 induction by atrazine-activated PXR.…”

Section: Metabolic Effects Of Edc Classes Potentially Mediated By mentioning

confidence: 99%

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

Küblbeck

Niskanen

Honkakoski

2020

Cells

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During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has emerged as a master activator of drug- and xenobiotic-metabolizing enzymes and transporters that govern the clearance of both exogenous and endogenous small molecules. Recent studies indicate that CAR participates, together with other nuclear receptors (NRs) and transcription factors, in regulation of hepatic glucose and lipid metabolism, hepatocyte communication, proliferation and toxicity, and liver tumor development in rodents. Endocrine-disrupting chemicals (EDCs) constitute a wide range of persistent organic compounds that have been associated with aberrations of hormone-dependent physiological processes. Their adverse health effects include metabolic alterations such as diabetes, obesity, and fatty liver disease in animal models and humans exposed to EDCs. As numerous xenobiotics can activate CAR, its role in EDC-elicited adverse metabolic effects has gained much interest. Here, we review the key features and mechanisms of CAR as a xenobiotic-sensing receptor, species differences and selectivity of CAR ligands, contribution of CAR to regulation hepatic metabolism, and evidence for CAR-dependent EDC action therein.

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“…In fact, resveratrol, a natural AhR antagonist, inhibits proteinuria, hypoalbuminemia and hyperlipidemia in nephritic rats (Nihei et al, 2001). Atrazine exposure has been shown to cause environmental nephrosis via direct kidney injury, whereas supplementary lycopenes provide significant protection against atrazine-induced renal injury and environmental nephrosis via their inhibition of the activation of AhR and the expression of cytochrome P450 isoforms (Xia et al, 2018). On the other hand, ARNT, a transcriptional co-activator of AhR, has been implicated in renal fibrosis and is sought as a therapeutic target in CKD; strong experimental support exists for a mechanistic model in which FK506 induces renoprotection (Tampe et al, 2018;Haase, 2019).…”

Section: Activated Ahr Aggravates Renal Damagementioning

confidence: 99%

The Aryl Hydrocarbon Receptor in Chronic Kidney Disease: Friend or Foe?

Wang

et al. 2020

Front. Cell Dev. Biol.

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The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes cell responses to small molecules derived from the diet, microorganisms, metabolism and pollutants. The AhR signal regulates many basic cellular processes, including cell cycle progression, adhesion, migration, apoptosis and cell proliferation. Many studies have shown that AhR is associated with chronic kidney disease (CKD) and its complications. This article reviews the current knowledge about the role of AhR in CKD, showing that AhR mediates CKD complications, including cardiovascular disease, anemia, bone disorders, cognitive dysfunction and malnutrition, and that it influences drug metabolism in individuals with CKD. AhR enhances the intestinal barrier function to reduce the harmful effects of uremic toxins. Therefore, understanding the complex roles of AhR during CKD is important to be able to target this transcription factor safely and effectively for CKD prevention and treatment.

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Atrazine-induced environmental nephrosis was mitigated by lycopene via modulating nuclear xenobiotic receptors-mediated response

Cited by 35 publications

References 89 publications

Lycopene inhibits IL‐1β‐induced inflammation in mouse chondrocytes and mediates murine osteoarthritis

Lycopene inhibits IL‐1β‐induced inflammation in mouse chondrocytes and mediates murine osteoarthritis

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

The Aryl Hydrocarbon Receptor in Chronic Kidney Disease: Friend or Foe?

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