Atrazine exposure in zebrafish induces aberrant genome-wide methylation

Wang, Shiyan; Bryan, Chris; Xie, Junkai; Zhao, Han; Li, Lin; Tai, Janiel Ahkin Chin; Horzmann, Katharine A.; Sánchez, Oscar F.; Zhang, Min; Freeman, Jennifer L.; Yuan, Ching

doi:10.1016/j.ntt.2022.107091

Cited by 11 publications

(3 citation statements)

References 77 publications

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“…In accordance with previous studies, ATZ is toxic to several organisms, with ecotoxicity studies involving hydrobios, earthworms, algae, and others. 31,32 Pesticides ingested into organisms are metabolized by the liver, which is the main metabolic organ, and lead to various hepatic disorders. Apoptosis and alterations in metabolite composition of liver cells of mice induced by ATZ have been reported.…”

Section: Discussionmentioning

confidence: 99%

Exogenous Melatonin Alleviates Atrazine-Induced Glucose Metabolism Disorders in Mice Liver via Suppressing Endoplasmic Reticulum Stress

Yang,

Wang,

Jian

et al. 2023

J. Agric. Food Chem.

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Atrazine (ATZ) is a widely used herbicide that has toxic effects on animals. Melatonin (MLT) is a natural hormone with strong antioxidant properties. However, the effect of MLT on the glucose metabolism disorder caused by ATZ is still unclear. Mice were divided into four groups randomly and given 21 days of gavage: blank control group (Con), 5 mg/kg MLT group (MLT), 170 mg/kg ATZ group (ATZ), and 170 mg/kg ATZ and 5 mg/kg MLT group (ATZ + MLT). The results show that ATZ alters mRNA levels of metabolic enzymes related to glycogen synthesis and glycolysis and increased metabolites (glycogen, lactate, and pyruvate). ATZ causes abnormalities in glucose metabolism in mouse liver, interfering with glycemia regulation ability. MLT can regulate the endoplasmic reticulum to respond to disordered glucose metabolism in mice liver. This study suggested that MLT has the power to alleviate the ATZ-induced glycogen overdeposition and glycolytic deficit.

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Section: Discussionmentioning

confidence: 99%

Exogenous Melatonin Alleviates Atrazine-Induced Glucose Metabolism Disorders in Mice Liver via Suppressing Endoplasmic Reticulum Stress

Yang,

Wang,

Jian

et al. 2023

J. Agric. Food Chem.

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“……………………………. (10) Where F is the fractional attainment of equilibrium obtained by this, q t /q e and K fd (meq -1 s 1/2 ) is the rate constant derived from a plot of In (1-F) against t. The values obtained as shown in Table 2 below indicate a very close range of R 2 values between those obtained from intraparticle diffusion and liquid film diffusion, implying that both surface sorption and penetration into the material's pore occurred almost the same rate, but more penetration into the material.…”

Section: Adsorption Kinetic Studymentioning

confidence: 99%

“…Once in groundwater, it degrades slowly, primarily through microbial activities. Its effects in humans and animals mainly involve the endocrine system and hormonal imbalance [10]. These pesticides adversely affect aquatic life and the ecosystem, causing biodiversity loss and being carcinogenic in nature [11].…”

Section: Introductionmentioning

confidence: 99%

Kinetic and Equilibrium Isotherm of Pesticides (Atrazine) Adsorption Unto Activated Carbon of Calabash (Lagenaria Siceraria)

Chukwudi-Madu

Agboeze

Chime

et al. 2022

EPRA

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The adsorption of pesticides (Atrazine) from water onto activated carbon prepared from calabash was investigated. The kinetic and equilibrium study was carried out, and data obtained showed that time duration, the concentration of the solution, the dosage of activated carbon and the pH of the solution greatly influenced the adsorption process. The adsorption kinetic study of the pesticide was done using various models. The result best fits pseudo-second-order using the coefficient regression value (0.9922) and intraparticle diffusion. Equilibrium isotherm data were analysed using the Langmuir isotherm model and Freundlich isotherm model. The result of the regression value provided Freundlich isotherm as the best fit to the experimental data, indicating the presence of heterogeneous layer sorption from the regression value of 0.7294. This study suggested that the activated carbon of calabash as a low-cost material is suitable for the adsorption of pesticides from water. Hence it could be applied as a cheap and effective material in removing pesticides in water bodies or industrial waste before disposal. KEYWORDS: Pesticides, activated carbon, adsorption capacity, isotherm, kinetic study, calabash.

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DNA Methylation Profiling of Ovarian Tissue of Climbing Perch (Anabas testudienus) in Response to Monocrotophos Exposure

Rasal,

Mohapatra,

Kumar

et al. 2023

Mar Biotechnol

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Atrazine exposure in zebrafish induces aberrant genome-wide methylation

Cited by 11 publications

References 77 publications

Exogenous Melatonin Alleviates Atrazine-Induced Glucose Metabolism Disorders in Mice Liver via Suppressing Endoplasmic Reticulum Stress

Exogenous Melatonin Alleviates Atrazine-Induced Glucose Metabolism Disorders in Mice Liver via Suppressing Endoplasmic Reticulum Stress

Kinetic and Equilibrium Isotherm of Pesticides (Atrazine) Adsorption Unto Activated Carbon of Calabash (Lagenaria Siceraria)

DNA Methylation Profiling of Ovarian Tissue of Climbing Perch (Anabas testudienus) in Response to Monocrotophos Exposure

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