Atraumatic splenic ruptures triggered both remission and death in a single case of blastic plasmacytoid dendritic cell neoplasm

Spontaneous Regression of Blastic Plasmacytoid Dendritic Cell Neoplasm Following Sepsis by <i>Serratia marcescens</i>: A Case Report and Literature Review

“…To date, four cases of spontaneous remission of BPDCN have been reported (16)(17)(18)(19) in the English literature, and we will review the five total cases, including our present one (Table). Four of the patients were men, and one was a woman.…”

“…SR in BPDCN is rare, partly due to the short history of the disease. To our knowledge, there have been only four reported cases of spontaneous remission of BPDCN ( 16 - 19 ) in the English literature, none of which were related to sepsis. We herein report the first case of spontaneous regression of BPDCN, with a decrease in tumor cells in the bone marrow following severe sepsis induced by Serratia marcescens .…”

Rapidly progressing blastic plasmacytoid dendritic cell neoplasm causing diffuse skin thickening: A case report with sequential computed tomography examinations

“…CT has been mainly used to assess the extent and depth of the skin lesions, as well as the metastases in patients with BPDCN [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] . CT shows round and ovoid homogeneous cutaneous mass with soft tissue density with or without subcutaneous invasion as seen in the present case.…”

“…Although there has been at least eleven reports of BPDCN with CT findings, knowledge of chronological changes of CT findings has been limited. To our knowledge, only two case reports demonstrated the sequential CTs, both of which showed the chronological changes of the involved spleen [ 13 , 14 ], we first report the time course of skin lesions of BPDCN with sequential CT examinations [7] . CT demonstrated that multiple skin nodules fused to each other, resulting in a thickening of the entire skin, with some surface erosions and crusting in this case.…”

“…Rapid progression to the terminal leukemic phase is common, resulting in a short mean survival of 12–16 months [3] . To our knowledge, there have been at least 11 reports with CT findings [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , including 4 18 F- fluorodeoxyglucose positron emission tomography / CT ( 18 F-FDG PET/CT) reports, associated with BPDCN; however, knowledge of chronological changes on sequential CT examinations have been limited [ 13 , 14 ]. We herein report a case of a patient with rapidly progressing BPDCN with a sequential evaluation on CT.…”