Atracurium, Vecuronium, and Intraocular Pressure in Humans

The Effect of Propofol and Alfentanil on the Increase in Intraocular Pressure Due to Succinylcholine and Intubation

“…Using a barbiturate and an intubating dose of a nondepolarizing muscle relaxant is often described as the method of choice for the emergency repair of a ruptured globe as non-depolarizing muscle relaxants do not raise IOP, as confirmed in this study (8)(9)(10)(11). This technique, however, has serious disadvantages including the risk of aspiration during the relatively long time the airway is unprotected.…”

Intraocular Pressure during Rapid Sequence Induction: Use of Moderate-dose Sufentanil or Fentanyl and Vecuronium or Atracurium

“…Rapid sequence induction using large doses of the nondepolarizing muscle relaxants vecuronium or atracurium is feasible, 1 and these relaxants themselves have no adverse effects on IOP. 2 A recent study demonstrated that several IV induction agents used in conjunction with atracurium and intratracheal lignocaine were effective in preventing a hypertensive lOP response to intubation. 3 decrease IOP.8 Therefore, we prospectively studied combinations of moderate dose sufentanil or fentanyl with vecuronium or atracurium following thiopentone as part of a rapid induction sequence and assessed subsequent effects on lOP, intubating oonditions, and cardiovascular stability.…”