Atractylenolide-I covalently binds to CYP11B2, selectively inhibits aldosterone synthesis, and improves hyperaldosteronism

Liu, Wenjuan; Li, Zhenqiang; Chu, Simeng; Ma, Xuan; Wang, Xiaoying; Jiang, Min; Bai, Gang

doi:10.1016/j.apsb.2021.09.013

Cited by 14 publications

(7 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, other studies have used 60 or 120 mg/kg ATL I to ameliorate acetaminophen-induced acute liver injury [33]. Another study used 10 to 40 mg/kg ATL I to inhibit aldosterone synthesis and improve hyperaldosteronism [52]. Taking these together, we believe that the dose of ATL I we used in the present study was safe.…”

Section: Discussionmentioning

confidence: 66%

“…To establish diet-induced obesity models, mice were fed a high-fat diet (D12492, Research Diets, New Brunswick, NJ, USA) for 8 weeks before ATL I (CSN16457, CSNpharm, Shanghai, China) (high dose (h): 4 mg/kg, ATL I medium dose (m): 2 mg/kg, and ATL I low dose (l): 1 mg/kg) treatment for another four weeks. Dimethyl sulfoxide (DMSO) (ST2335, Beyotime, Shanghai, China) was set as vehicle, and saline was set as negative control [52]. All animal care and experimental studies were approved by and in accordance with the guidelines of the Animal Ethics Committee of Guangdong Medical University.…”

Section: Animal Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

ATL I, Acts as a SIRT6 Activator to Alleviate Hepatic Steatosis in Mice via Suppression of NLRP3 Inflammasome Formation

et al. 2022

View full text Add to dashboard Cite

Accumulating evidence has highlighted that sirtuin-6 (SIRT6) plays an important role in hepatic gluconeogenesis and lipogenesis. We aim to investigate the underlying mechanisms and pharmacological interventions of SIRT6 on hepatic steatosis treatment. Herein, our results showed that atractylenolide I (ATL I) activated the deacetylase activity of SIRT6 to promote peroxisome proliferator-activated receptor alpha (PPARα) transcription and translation, while suppressing nuclear factor NF-kappa-B (NFκB)-induced NACHT, LRR, and PYD domains containing protein 3 (NLRP3) inflammasome formation. Together, these decreased the infiltration of F4/80 and CD11B positive macrophages, accompanied by decreased mRNA expression and serum levels of tumor necrosis factor alpha (TNF-α), interleukin-6 (IL6), and interleukin-1 beta (IL1β). Additionally, these changes decreased sterol regulatory element-binding protein-1c (SREBP-1c) expression, while restoring carnitine O-palmitoyltransferase 1a (Cpt1a) expression, to decrease the size of adipocytes and adipose deposition, which, in turn, reversed high-fat diet (HFD)-induced liver weight and body weight accumulation in C57 mice. SIRT6 knockout or hepatic SIRT6 knockout in C57 mice largely abolished the effect of ATL I on ameliorating hepatic steatosis. Taken together, our results suggest that ATL I acts as a promising compound that activates SIRT6/PPARα signaling and attenuates the NLRP3 inflammasome to ameliorate hepatic inflammation and steatosis.

show abstract

Section: Discussionmentioning

confidence: 66%

Section: Animal Treatmentmentioning

confidence: 99%

ATL I, Acts as a SIRT6 Activator to Alleviate Hepatic Steatosis in Mice via Suppression of NLRP3 Inflammasome Formation

et al. 2022

View full text Add to dashboard Cite

show abstract

“…For example, TCM includes multiple types of antidiarrheal drugs, each exerting different effects on symptoms and the intestinal bacterial community despite all being used to treat diarrhea [ 16 ]. The beneficial efficacies of TCM are summarized in terms of various treatment outcomes, such as qi-tonifying and drying dampness , which have facilitated clinical applications [ 17 , 18 ]. These concise descriptions were closely related to the organic functions of the human body.…”

Section: The Modernization Of Traditional Chinese Medicinementioning

confidence: 99%

Lab-on-a-chip: an advanced technology for the modernization of traditional Chinese medicine

Lu,

Yuan,

Han

et al. 2024

Chin Med

View full text Add to dashboard Cite

Benefiting from the complex system composed of various constituents, medicament portions, species, and places of origin, traditional Chinese medicine (TCM) possesses numerous customizable and adaptable efficacies in clinical practice guided by its theories. However, these unique features are also present challenges in areas such as quality control, screening active ingredients, studying cell and organ pharmacology, and characterizing the compatibility between different Chinese medicines. Drawing inspiration from the holistic concept, an integrated strategy and pattern more aligned with TCM research emerges, necessitating the integration of novel technology into TCM modernization. The microfluidic chip serves as a powerful platform for integrating technologies in chemistry, biology, and biophysics. Microfluidics has given rise to innovative patterns like lab-on-a-chip and organoids-on-a-chip, effectively challenging the conventional research paradigms of TCM. This review provides a systematic summary of the nature and advanced utilization of microfluidic chips in TCM, focusing on quality control, active ingredient screening/separation, pharmaceutical analysis, and pharmacological/toxicological assays. Drawing on these remarkable references, the challenges, opportunities, and future trends of microfluidic chips in TCM are also comprehensively discussed, providing valuable insights into the development of TCM.

show abstract

“…ATL I and III are hypotensive and useful in the treatment of aldosteronism [ 109 ] and pre-eclampsia. Pre-eclampsia is a common hypertension disease that increases the risk of maternal and fetal morbidity and mortality during pregnancy [ 110 ].…”

Section: Pharmacological Effects Of Atractylenolidesmentioning

confidence: 99%

Chemical Constitution, Pharmacological Effects and the Underlying Mechanism of Atractylenolides: A Review

Xie

Lin

et al. 2023

Molecules

View full text Add to dashboard Cite

Atractylenolides, comprising atractylenolide I, II, and III, represent the principal bioactive constituents of Atractylodes macrocephala, a traditional Chinese medicine. These compounds exhibit a diverse array of pharmacological properties, including anti-inflammatory, anti-cancer, and organ-protective effects, underscoring their potential for future research and development. Recent investigations have demonstrated that the anti-cancer activity of the three atractylenolides can be attributed to their influence on the JAK2/STAT3 signaling pathway. Additionally, the TLR4/NF-κB, PI3K/Akt, and MAPK signaling pathways primarily mediate the anti-inflammatory effects of these compounds. Atractylenolides can protect multiple organs by modulating oxidative stress, attenuating the inflammatory response, activating anti-apoptotic signaling pathways, and inhibiting cell apoptosis. These protective effects extend to the heart, liver, lung, kidney, stomach, intestine, and nervous system. Consequently, atractylenolides may emerge as clinically relevant multi-organ protective agents in the future. Notably, the pharmacological activities of the three atractylenolides differ. Atractylenolide I and III demonstrate potent anti-inflammatory and organ-protective properties, whereas the effects of atractylenolide II are infrequently reported. This review systematically examines the literature on atractylenolides published in recent years, with a primary emphasis on their pharmacological properties, in order to inform future development and application efforts.

show abstract

Atractylenolide-I covalently binds to CYP11B2, selectively inhibits aldosterone synthesis, and improves hyperaldosteronism

Cited by 14 publications

References 58 publications

ATL I, Acts as a SIRT6 Activator to Alleviate Hepatic Steatosis in Mice via Suppression of NLRP3 Inflammasome Formation

ATL I, Acts as a SIRT6 Activator to Alleviate Hepatic Steatosis in Mice via Suppression of NLRP3 Inflammasome Formation

Lab-on-a-chip: an advanced technology for the modernization of traditional Chinese medicine

Chemical Constitution, Pharmacological Effects and the Underlying Mechanism of Atractylenolides: A Review

Contact Info

Product

Resources

About