ATRA Entrapped in DSPC Liposome Enhances Anti-metastasis Effect on Lung and Liver During B16F10 Cell Line Metastasis in C57BL6 Mice

Reji, Reshma; Siddikuzzaman,; Grace, V. M. Berlin

doi:10.2174/1871520616666160927103458

Cited by 3 publications

(1 citation statement)

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“…Moreover, ATRA reduced IL13-induced secretion of MMP-12 [108]. Similarly, ATRA treatment inhibited tumor nodules in C57BL/6 mice injected with B16F10 murine melanoma cells compared to metastatic controls, especially in the lungs and liver [109]. Furthermore, a long period of paclitaxel administration leads to the EMT phenotype and related metastasis and resistance.…”

Section: All-trans Retinoic Acidsmentioning

confidence: 92%

Carotenoids in Cancer Metastasis—Status Quo and Outlook

et al. 2020

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Metastasis represents a major obstacle in cancer treatment and the leading cause of cancer-related deaths. Therefore, the identification of compounds targeting the multi-step and complex process of metastasis could improve outcomes in the management of cancer patients. Carotenoids are naturally occurring pigments with a plethora of biological activities. Carotenoids exert a potent anti-cancer capacity in various cancer models in vitro and in vivo, mediated by the modulation of signaling pathways involved in the migration and invasion of cancer cells and metastatic progression, including key regulators of the epithelial–mesenchymal transition and regulatory molecules, such as matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), urokinase plasminogen activator (uPA) and its receptor (uPAR), hypoxia-inducible factor-1α (HIF-1α), and others. Moreover, carotenoids modulate the expression of genes associated with cancer progression and inflammatory processes as key mediators of the complex process involved in metastasis. Nevertheless, due to the predominantly preclinical nature of the known anti-tumor effects of carotenoids, and unclear results from certain carotenoids in specific cancer types and/or specific parts of the population, a precise analysis of the anti-cancer effects of carotenoids is essential. The identification of carotenoids as effective compounds targeting the complex process of cancer progression could improve the outcomes of advanced cancer patients.

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Section: All-trans Retinoic Acidsmentioning

confidence: 92%