Abstract:Mitophagy is essential for the maintenance of mitochondrial quality control (MQC) and neuronal survival. Defects in mitophagy have been implicated in the onset and progression of Parkinson’s disease (PD). However, the underlying mechanisms of mitophagy in the pathogenesis of PD remains unclear. Here, the AAA+ ATPase Thorase was identified being essential for mitophagy. Mice lacking Thorase exhibited PD-like behavior and α-synucleinopathy in the brains. Genetic deletion of Thorase exacerbated phenotypes of α-sy… Show more
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