ATP2B1 genotypes rs2070759 and rs2681472 polymorphisms and risk of hypertension in Saudi population

Althwab, Sami A.; Ahmed, Ahmed A.; Rasheed, Zafar; Alkhowailed, Mohammad S.; Hershan, Almonther; Alsagaby, Suliman A.; Alblihed, Mohamed A.; Alaqeel, Aqeel; Alrehaili, Jihad; Alhumaydhi, Fahad A.; Alkhamiss, Abdullah; Abdulmonem, Waleed Al

doi:10.1080/15257770.2021.1973034

Cited by 2 publications

(5 citation statements)

References 35 publications

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“…Another meta‐analysis highlighted a significant association of rs17249754 (G/A) (OR = 1.19, 95% CI: 1.10−1.28) and rs2681472 (A/G) (OR = 1.15, 95% CI: 1.12−1.17) with the risk of hypertension, as well as with high SBP and DBP 20 . The ATP2B1 genotypes rs2070759 and rs2681472 were also strongly associated with the risk of hypertension in the Saudi population 38 . Another case‐control study in West Africa that involved patients with essential hypertension and normotensive individuals reported a strong association between ATP2B1 rs17249754 and hypertension 40 …”

Section: Discussionmentioning

confidence: 94%

“…Previous genome‐wide and gene‐centric studies have established strong associations of the ATP2B1 locus with SBP and DBP, as well as with hypertension 8,10,37,38 . Among East Asians, ATP2B1 rs2681472 is associated with a risk of CAD 39 .…”

Section: Discussionmentioning

confidence: 99%

“…20 The ATP2B1 genotypes rs2070759 and rs2681472 were also strongly associated with the risk of hypertension in the Saudi population. 38 Another case-control study in West Africa that involved patients with essential hypertension and normotensive individuals reported a strong association between ATP2B1 rs17249754 and hypertension. The ATP2B1 rs12817819 allele is associated with an increased risk of RHT in hypertension participants with CAD or suspected ischemic heart disease.…”

Section: Discussionmentioning

confidence: 99%

“…Previous genome‐wide and gene‐centric studies have established strong associations of the ATP2B1 locus with SBP and DBP, as well as with hypertension. 8 , 10 , 37 , 38 Among East Asians, ATP2B1 rs2681472 is associated with a risk of CAD. 39 Among the 29 000 participants from the CHARGE consortium, the odds of developing hypertension was higher by 17% for rs2681472 carriers.…”

Section: Discussionmentioning

confidence: 99%

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ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population

Kobayashi,

Yatsu,

Haruna

et al. 2024

J of Clinical Hypertension

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Single‐nucleotide polymorphisms (SNP) of ATP2B1 gene are associated with essential hypertension but their association with resistant hypertension (RHT) remains unexplored. The authors examined the relationship between ATP2B1 SNPs and RHT by genotyping 12 SNPs in ATP2B1 gene of 1124 Japanese individuals with lifestyle‐related diseases. Patients with RHT had inadequate blood pressure (BP) control using three antihypertensive drugs or used ≥4 antihypertensive drugs. Patients with controlled hypertension had BP controlled using ≤3 antihypertensive drugs. The association between each SNP and RHT was analyzed by logistic regression. The final cohort had 888 (79.0%) and 43 (3.8%) patients with controlled hypertension and RHT, respectively. Compared with patients homozygous for the minor allele of each SNP in ATP2B1, a significantly higher number of patients carrying the major allele at 10 SNPs exhibited RHT (most significant at rs1401982: 5.8% vs. 0.8%, p = .014; least significant at rs11105378: 5.7% vs. 0.9%, p = .035; most nonsignificant at rs12817819: 5.1% vs. 10%, p = .413). After multivariate adjustment for age, sex, systolic BP, and other confounders, the association remained significant for rs2681472 and rs1401982 (OR: 7.60, p < .05 and OR: 7.62, p = .049, respectively). Additionally, rs2681472 and rs1401982 were in linkage disequilibrium with rs11105378. This study identified two ATP2B1 SNPs associated with RHT in the Japanese population. rs1401982 was most closely associated with RHT, and major allele carriers of rs1401982 required significantly more antihypertensive medications. Analysis of ATP2B1 SNPs in patients with hypertension can help in early prediction of RHT and identification of high‐risk patients who are more likely to require more antihypertensive medications.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population

Kobayashi,

Yatsu,

Haruna

et al. 2024

J of Clinical Hypertension

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“…", since not everyone, even GWAS/EAWAS-significant polymorphism, will determine the susceptibility to AH in the study population. In this regard, replication studies are becoming particularly relevant [24][25][26][27][28], aimed at confirming (or, conversely, refuting) the role of GWAS gene polymorphism in the AH formation in residents of a particular territory having their own characteristics of the genetic "constitution", the action of environmental factors, intergenic and gene-environmental relationships, etc., predetermining and features of the candidate genes involvement in the disease (AH) formation.…”

Section: Introductionmentioning

confidence: 99%

Risk Effects of rs1799945 Polymorphism of the HFE Gene and Intergenic Interactions of GWAS-Significant Loci for Arterial Hypertension in the Caucasian Population of Central Russia

Иванова

Churnosova

Abramova

et al. 2023

IJMS

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The aim of this case-control replicative study was to investigate the link between GWAS-impact for arterial hypertension (AH) and/or blood pressure (BP) gene polymorphisms and AH risk in Russian subjects (Caucasian population of Central Russia). AH (n = 939) and control (n = 466) cohorts were examined for ten GWAS AH/BP risk loci. The genotypes/alleles of these SNP and their combinations (SNP–SNP interactions) were tested for their association with the AH development using a logistic regression statistical procedure. The genotype GG of the SNP rs1799945 (C/G) HFE was strongly linked with an increased AH risk (ORrecGG = 2.53; 95%CIrecGG1.03–6.23; ppermGG = 0.045). The seven SNPs such as rs1173771 (G/A) AC026703.1, rs1799945 (C/G) HFE, rs805303 (G/A) BAG6, rs932764 (A/G) PLCE1, rs4387287 (C/A) OBFC1, rs7302981 (G/A) CERS5, rs167479 (T/G) RGL3, out of ten regarded loci, were related with AH within eight SNP–SNP interaction models (<0.001 ≤ pperm-interaction ≤ 0.047). Three polymorphisms such as rs8068318 (T/C) TBX2, rs633185 (C/G) ARHGAP42, and rs2681472 (A/G) ATP2B1 were not linked with AH. The pairwise rs805303 (G/A) BAG6–rs7302981 (G/A) CERS5 combination was a priority in determining the susceptibility to AH (included in six out of eight SNP–SNP interaction models [75%] and described 0.82% AH entropy). AH-associated variants are conjecturally functional for 101 genes involved in processes related to the immune system (major histocompatibility complex protein, processing/presentation of antigens, immune system process regulation, etc.). In conclusion, the rs1799945 polymorphism of the HFE gene and intergenic interactions of BAG6, CERS5, AC026703.1, HFE, PLCE1, OBFC1, RGL3 have been linked with AH risky in the Caucasian population of Central Russia.

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ATP2B1 genotypes rs2070759 and rs2681472 polymorphisms and risk of hypertension in Saudi population

Cited by 2 publications

References 35 publications

ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population

ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population

Risk Effects of rs1799945 Polymorphism of the HFE Gene and Intergenic Interactions of GWAS-Significant Loci for Arterial Hypertension in the Caucasian Population of Central Russia

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