ATP serves an anti-inflammatory role by enhancing β-defensin-2 response in acute pneumonia of rat

Shen, Zhenwei; Zhou, Yun; Qu, Le; Han, Lei

doi:10.3892/br.2017.906

Cited by 3 publications

(3 citation statements)

References 30 publications

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“… 10 Recently, it was hypothesized that HBD-2 could suppress dendritic cell-mediated secretions of pro-inflammatory cytokines such as IL-1β, IL-12, and TNF-α in Inflammatory Bowel Disease (IBD) 28 as well as decrease IL-6 and TNF-α in lung tissues. 29 Also, HBD-3 reduces the secretion of IL-6 and IL-8, showing hopeful potential as adjuvant therapy for the treatment of inflammatory periodontitis. 9 …”

Section: Discussionmentioning

confidence: 99%

Human beta-defensin 1 circulating level and gene polymorphism in non-segmental vitiligo Egyptian patients

Farag¹,

Shoeib²,

Labeeb³

et al. 2023

Anais Brasileiros de Dermatologia

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Section: Discussionmentioning

confidence: 99%

Human beta-defensin 1 circulating level and gene polymorphism in non-segmental vitiligo Egyptian patients

Farag¹,

Shoeib²,

Labeeb³

et al. 2023

Anais Brasileiros de Dermatologia

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“…the mice showed ameliorated survival after skin flap infection by PA introduced through catheters (Casal et al ., 2019 ). Likewise, the overexpression of β‐defensin 2 in rats improved the outcome of PA lung infection, demonstrating the important protection exerted by these CAMPs in vivo (Shen et al ., 2017 ). As recently demonstrated for diverse HNPs (Zheng et al ., 2018 ), besides their obviously beneficial bactericidal activity (McHugh et al ., 2019 ), defensins show pro‐inflammatory properties which, depending on their levels and context of infection, can lead to excessive and harmful consequences for the host.…”

Section: Bacterial Envelope‐targeting Mammalian Humoral Innate Immuni...mentioning

confidence: 99%

Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug‐resistant Gram‐negatives

et al. 2022

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Mammalian innate immunity employs several humoral ‘weapons’ that target the bacterial envelope. The threats posed by the multidrug‐resistant ‘ESKAPE’ Gram‐negative pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) are forcing researchers to explore new therapeutic options, including the use of these immune elements. Here we review bacterial envelope‐targeting (peptidoglycan and/or membrane‐targeting) proteins/peptides of the mammalian immune system that are most likely to have therapeutic applications. Firstly we discuss their general features and protective activity against ESKAPE Gram‐negatives in the host. We then gather, integrate, and discuss recent research on experimental therapeutics harnessing their bactericidal power, based on their exogenous administration and also on the discovery of bacterial and/or host targets that improve the performance of this endogenous immunity, as a novel therapeutic concept. We identify weak points and knowledge gaps in current research in this field and suggest areas for future work to obtain successful envelope‐targeting therapeutic options to tackle the challenge of antimicrobial resistance.

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“…β-defensins are ubiquitously expressed by epithelial cells throughout the body, but β-defensin-1, -2, and -3 are the most studied respiratory tract β-defensins [ 116 , 176 ]. In addition to their antimicrobial role, β-defensins have been found to serve as both proinflammatory mediators [ 177 , 178 , 179 ] and attenuators [ 180 , 181 , 182 ] of the innate immune response, with the former better understood than the latter [ 183 ]. θ-defensins are not naturally expressed in humans and only exist in our genome as pseudogenes [ 116 ].…”

Section: Components Of the Extracellular Barrier In The Respiratormentioning

confidence: 99%

Leveraging 3D Model Systems to Understand Viral Interactions with the Respiratory Mucosa

Iverson

Kaler

Agostino

et al. 2020

Viruses

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Respiratory viruses remain a significant cause of morbidity and mortality in the human population, underscoring the importance of ongoing basic research into virus–host interactions. However, many critical aspects of infection are difficult, if not impossible, to probe using standard cell lines, 2D culture formats, or even animal models. In vitro systems such as airway epithelial cultures at air–liquid interface, organoids, or ‘on-chip’ technologies allow interrogation in human cells and recapitulate emergent properties of the airway epithelium—the primary target for respiratory virus infection. While some of these models have been used for over thirty years, ongoing advancements in both culture techniques and analytical tools continue to provide new opportunities to investigate airway epithelial biology and viral infection phenotypes in both normal and diseased host backgrounds. Here we review these models and their application to studying respiratory viruses. Furthermore, given the ability of these systems to recapitulate the extracellular microenvironment, we evaluate their potential to serve as a platform for studies specifically addressing viral interactions at the mucosal surface and detail techniques that can be employed to expand our understanding.

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ATP serves an anti-inflammatory role by enhancing β-defensin-2 response in acute pneumonia of rat

Cited by 3 publications

References 30 publications

Human beta-defensin 1 circulating level and gene polymorphism in non-segmental vitiligo Egyptian patients

Human beta-defensin 1 circulating level and gene polymorphism in non-segmental vitiligo Egyptian patients

Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug‐resistant Gram‐negatives

Leveraging 3D Model Systems to Understand Viral Interactions with the Respiratory Mucosa

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