ATP‐Responsive Nanoparticles Covered with Biomolecular Machine “Chaperonin GroEL”

Shen, Hao K.; Morishita, Kiyoshi; Hashim, P. K.; Okuro, Kou; Kashiwagi, Daiki; Kimura, Akihiko; Yanagisawa, Haruaki; Kikkawa, Masahide; Niwa, Tatsuya; Taguchi, Hideki; Aida, Takuzo

doi:10.1002/anie.202304894

Cited by 3 publications

(3 citation statements)

References 69 publications

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“…The best molecular machines are often found in biological systems. They are called biomolecular machines [317,318]. For example, the contractile proteins actin and myosin are very attractive targets for nanotechnology [319,320].…”

Section: Molecular Machine In Surface Spacementioning

confidence: 99%

Confined Space Nanoarchitectonics for Dynamic Functions and Molecular Machines

Ariga

2024

Micromachines

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Nanotechnology has advanced the techniques for elucidating phenomena at the atomic, molecular, and nano-level. As a post nanotechnology concept, nanoarchitectonics has emerged to create functional materials from unit structures. Consider the material function when nanoarchitectonics enables the design of materials whose internal structure is controlled at the nanometer level. Material function is determined by two elements. These are the functional unit that forms the core of the function and the environment (matrix) that surrounds it. This review paper discusses the nanoarchitectonics of confined space, which is a field for controlling functional materials and molecular machines. The first few sections introduce some of the various dynamic functions in confined spaces, considering molecular space, materials space, and biospace. In the latter two sections, examples of research on the behavior of molecular machines, such as molecular motors, in confined spaces are discussed. In particular, surface space and internal nanospace are taken up as typical examples of confined space. What these examples show is that not only the central functional unit, but also the surrounding spatial configuration is necessary for higher functional expression. Nanoarchitectonics will play important roles in the architecture of such a total system.

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Section: Molecular Machine In Surface Spacementioning

confidence: 99%

Confined Space Nanoarchitectonics for Dynamic Functions and Molecular Machines

Ariga

2024

Micromachines

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“…Interestingly, in some tumor tissues, the ATP concentration is substantially higher compared to normal tissues, displaying a 1.2-fold increase in cancer cells. 113 Recent reports have illuminated four commonly used delivery systems that rely on ATP-sensitive moieties: Zinc-dipicolylamine (TDPA-Zn 2+ ), 114 phenylboronic acid-sugar-functional polymers, 115 ATP-consuming enzymes, 116 and ATP aptamers. 117 In the following sections, we will explore the application of these modules in ATP-sensitive delivery systems.…”

Section: Atp- Responsive Drug Delivery Systemsmentioning

confidence: 99%

“…In this system, GroEL contains cysteine residues that coordinate with merocyanine (MC)-Mg 2+ -MC, resulting in the formation of nanotubes (NB). 116 Cargos were then encapsulated within the NBs. The conformation of ATP-bound GroEL differed from apo-GroEL, leading to the disruption of MC-Mg 2+ -MC interaction.…”

Section: Atp- Responsive Drug Delivery Systemsmentioning

confidence: 99%

Smart Nanoplatforms Responding to the Tumor Microenvironment for Precise Drug Delivery in Cancer Therapy

Wang,

Deng,

Liu

et al. 2024

IJN

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Protein Nanotubes as Advanced Material Platforms and Delivery Systems

Liu,

Li,

Zhang

et al. 2023

Advanced Materials

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Protein nanotubes (PNTs) as state‐of‐the‐art nanocarriers are promising for various potential applications both in the food and pharmaceutical industries. Due to the edible starting sources, i.e., α‐lactalbumin, lysozyme, bovine serum albumin, and ovalbumin, PNTs bear properties of biocompatibility and biodegradability. Additionally, their large specific surface area and hydrophobic core can be used for chemical modification and loading of bioactive substances, respectively. Moreover, their enhanced permeability and penetration ability across biological barriers such as intestinal mucus, extracellular matrix, thrombus clot, and biofilms, make it a promising delivery platform and biomaterials for health‐related applications and biological systems. Most importantly, their simple preparation processes enable large‐scale production, making it possible targeting applications in the biomedical and nanotechnological fields. Understanding the self‐assembly principles for these systems is important for controlling their morphology, size, and shape, and thus provides the ground to a multitude of applications. Here, we comprehensively review the current state‐of‐the‐art of PNTs including their building materials, physicochemical properties, self‐assembly and formation mechanisms. We then discuss and highlight the advantages and limitations, as well as challenges and prospects of these PNTs for their successful application in biomaterial and pharmaceutical sectors. We also highlight potential cytotoxicity of PNTs and the need of regulations as a critical factor for enabling in vivo applications. In the end, a brief summary and future prospects for PNTs as advanced material platforms and delivery systems are included.This article is protected by copyright. All rights reserved

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ATP‐Responsive Nanoparticles Covered with Biomolecular Machine “Chaperonin GroEL”

Cited by 3 publications

References 69 publications

Confined Space Nanoarchitectonics for Dynamic Functions and Molecular Machines

Confined Space Nanoarchitectonics for Dynamic Functions and Molecular Machines

Smart Nanoplatforms Responding to the Tumor Microenvironment for Precise Drug Delivery in Cancer Therapy

Protein Nanotubes as Advanced Material Platforms and Delivery Systems

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