Abstract:Advanced understanding of
Alzheimer’s disease (AD) and several tauopathies over the past decades
indicates the pathological importance of tau aggregation in these diseases.
Herein, we demonstrated that adenosine triphosphate (ATP), a highly charged
anionic molecule abundant in the cytosol of cells, catalyses tau fibrillation via
supramolecular complexation with basic residues of tau. Our results showed that
ATP attracts multiple lysine residues of four-repeat domain of tau (K18),
thereby immediately forming di… Show more
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