ATP dependence of the non-specific ion channel in Torpedo synaptic vesicles

Ahdut-HaCohen, Ronit; Meiri, Halina; Rahamimoff, Rami

doi:10.1097/00001756-200604240-00019

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…2007). Interestingly the concentration of ATP measured in synaptic vesicles of Torpedo was rather high, approaching 120 m m (Ahdut‐Hacohen et al. 2006).…”

Section: Lower Vertebratesmentioning

confidence: 99%

Evolutionary origins of the purinergic signalling system

2009

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Purines appear to be the most primitive and widespread chemical messengers in the animal and plant kingdoms. The evidence for purinergic signalling in plants, invertebrates and lower vertebrates is reviewed. Much is based on pharmacological studies, but important recent studies have utilized the techniques of molecular biology and receptors have been cloned and characterized in primitive invertebrates, including the social amoeba Dictyostelium and the platyhelminth Schistosoma, as well as the green algae Ostreococcus, which resemble P2X receptors identified in mammals. This suggests that contrary to earlier speculations, P2X ion channel receptors appeared early in evolution, while G protein-coupled P1 and P2Y receptors were introduced either at the same time or perhaps even later. The absence of gene coding for P2X receptors in some animal groups [e.g. in some insects, roundworms (Caenorhabditis elegans) and the plant Arabidopsis] in contrast to the potent pharmacological actions of nucleotides in the same species, suggests that novel receptors are still to be discovered.

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“…2007). Interestingly the concentration of ATP measured in synaptic vesicles of Torpedo was rather high, approaching 120 m m (Ahdut‐Hacohen et al. 2006).…”

Section: Lower Vertebratesmentioning

confidence: 99%

Evolutionary origins of the purinergic signalling system

2009

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“…To date, much of the evidence for purinergic involvement in skeletal neuromuscular transmission has come from studies of the fish electric organ, frog and chick neuromuscular junctions (see [13] and [14][15][16][17][18][19][20][21]). …”

Section: Skeletal Neuromuscular Junctionmentioning

confidence: 99%

Purinergic signalling in the musculoskeletal system

Burnstock

Arnett

Orriss

2013

Purinergic Signalling

109

114

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It is now widely recognised that extracellular nucleotides, signalling via purinergic receptors, participate in numerous biological processes in most tissues. It has become evident that extracellular nucleotides have significant regulatory effects in the musculoskeletal system. In early development, ATP released from motor nerves along with acetylcholine acts as a cotransmitter in neuromuscular transmission; in mature animals, ATP functions as a neuromodulator. Purinergic receptors expressed by skeletal muscle and satellite cells play important pathophysiological roles in their development or repair. In many cell types, expression of purinergic receptors is often dependent on differentiation. For example, sequential expression of P2X5, P2Y 1 and P2X2 receptors occurs during muscle regeneration in the mdx model of muscular dystrophy. In bone and cartilage cells, the functional effects of purinergic signalling appear to be largely negative. ATP stimulates the formation and activation of osteoclasts, the bone-destroying cells. Another role appears to be as a potent local inhibitor of mineralisation. In osteoblasts, the bone-forming cells, ATP acts via P2 receptors to limit bone mineralisation by inhibiting alkaline phosphatase expression and activity. Extracellular ATP additionally exerts significant effects on mineralisation via its hydrolysis product, pyrophosphate. Evidence now suggests that purinergic signalling is potentially important in several bone and joint disorders including osteoporosis, rheumatoid arthritis and cancers. Strategies for future musculoskeletal therapies might involve modulation of purinergic receptor function or of the ecto-nucleotidases responsible for ATP breakdown or ATP transport inhibitors.

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Evolution of Purinergic Signalling

Burnstock

Verkhratsky

2012

Purinergic Signalling and the Nervous System

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ATP dependence of the non-specific ion channel in Torpedo synaptic vesicles

Cited by 6 publications

References 25 publications

Evolutionary origins of the purinergic signalling system

Evolutionary origins of the purinergic signalling system

Purinergic signalling in the musculoskeletal system

Evolution of Purinergic Signalling

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