ATP burst is the dominant driver of antibiotic lethality in Mycobacteria
Tejan Lodhiya,
Aseem Palande,
Anjali Veeram
et al.
Abstract:Antibiotic-tolerant bacteria, due to their unique physiology, are refractory to antimicrobial killing and pose challenges for successful therapy.M. tuberculosis, the causative agent of tuberculosis (TB), is exceptionally difficult to control due to antibiotic tolerance. Incomplete knowledge of how bactericidal antibiotics work has impeded our understanding of the development of antibiotic tolerance in mycobacteria. In this study, using quantitative proteomics,13C-isotopomer analysis, and biochemical assays, we… Show more
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