ATP-Binding Cassette Transporters in the Heart

The ATP-Binding Cassette Transporters and Their Implication in Drug Disposition: A Special Look at the Heart

“…These will not be discussed extensively in this manuscript but are discussed elsewhere (Solbach et al, 2006).…”

Functional characterization and substrate specificity of a novel gene encoding zinc finger-like protein, ZfLp, in <i>Xenopus laevis</i> oocytes

“…On the other hand, human organic solute transporters such as SLCO21A/ Slco21a, SLCO22A/Slco22a and SLC3A1/2 have several membrane-spanning domains. Similarly, ABC transporters are also predicted to have 6 to 12 membrane spanning domains (Solbach et al, 2006). One possible structural feature for activating the drug transport seems to require the transmembrane signature.…”

“…Rose hydropathyl analysis predicted that there are several transmembranes; however, no membrane-spanning domains were predicted by other analyses, suggesting that, at least partly, ZfLp may have transmembrane domain(s). Based on previous papers (Kanai et al, 1998;Ballatori et al, 2005;Kobayashi et al, 2005aKobayashi et al, , 2005bKobayashi et al, , 2010aKobayashi et al, and 2010bSolbach et al, 2006), we conducted uptake experiments using ZfLp-cRNA-injected oocytes. Surprisingly, we found that ZfLp mediates the transport of [ 3 H]paclitaxel (taxol) and [ 3 H]5-FU.…”

Ribosomal protein L3 mediated the transport of digoxin in Xenopus laevis oocyte

“…For example, the OAT (SLC22A), the OCT (SLC22A) and the OATP (SLCO21A/ SLC21A) families predict to have 10 to 12 membrane spanning domains. Similarly, ABC transporters also predicted to have 6 to 12 membrane spanning domains (Solbach et al, 2006). Based on these findings, Kyte and Doolittle hydropathy plot (window 9) analysis was firstly examined to examine whether RPL3 have membrane spanning domain(s).…”