ATP‑binding cassette transporter A1: A promising therapy target for prostate cancer (Review)

Xiong, Tingting; Xu, Gang; Huang, Xue‐Long; Lu, Kaiqiang; Xie, Weiquan; Yin, Kai; Tu, Jian

doi:10.3892/mco.2017.1506

Cited by 13 publications

(11 citation statements)

References 57 publications

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“…Sadly, other interesting ABCs, e.g., antigen processing ABCB2/ABCB3 or the translation regulating ABCE1, belong to the less studied molecules, similar to the physiologically important ABCs from A, D, and G subfamilies ( Table 1 ). The role of physiological substrates and active ABCs in cancer is being increasingly studied [ 170 , 171 , 172 ].…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer

Vrána

Hlaváč

Brynychová

et al. 2018

IJMS

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The prognosis of esophageal cancer (EC) is poor, despite considerable effort of both experimental scientists and clinicians. The tri-modality treatment consisting of neoadjuvant chemoradiation followed by surgery has remained the gold standard over decades, unfortunately, without significant progress in recent years. Suitable prognostic factors indicating which patients will benefit from this tri-modality treatment are missing. Some patients rapidly progress on the neoadjuvant chemoradiotherapy, which is thus useless and sometimes even harmful. At the same time, other patients achieve complete remission on neoadjuvant chemoradiotherapy and subsequent surgery may increase their risk of morbidity and mortality. The prognosis of patients ranges from excellent to extremely poor. Considering these differences, the role of drug metabolizing enzymes and transporters, among other factors, in the EC response to chemotherapy may be more important compared, for example, with pancreatic cancer where all patients progress on chemotherapy regardless of the treatment or disease stage. This review surveys published literature describing the potential role of ATP-binding cassette transporters, the genetic polymorphisms, epigenetic regulations, and phenotypic changes in the prognosis and therapy of EC. The review provides knowledge base for further research of potential predictive biomarkers that will allow the stratification of patients into defined groups for optimal therapeutic outcome.

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Section: Conclusion and Future Prospectsmentioning

confidence: 99%

ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer

Vrána

Hlaváč

Brynychová

et al. 2018

IJMS

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“…For example, it has been reported that metabolic syndrome (MetS) is an obvious pathogenic factor for epithelial ovarian cancer [ 17 ]. The loss of cellular cholesterol homeostasis has been found frequently in prostate cancer cells [ 18 ]. Additionally, obesity has been confirmed to support the development and progression of melanoma and controlling body weight is effective for suppressing melanoma [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of ATP-binding cassette transporters on metabolic diseases

Lü

2020

Nutr Metab (Lond)

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Currently, many people worldwide suffer from metabolic diseases caused by heredity and external factors, such as diet. One of the symptoms of metabolic diseases is abnormal lipid metabolism. ATP binding cassette (ABC) transporters are one of the largest transport protein superfamilies that exist in nearly all living organisms and are mainly located on lipid-processing cells. ABC transporters have been confirmed to be closely related to the pathogenesis of diseases such as metabolic diseases, cancer and Alzheimer’s disease based on their transport abilities. Notably, the capability to transport lipids makes ABC transporters critical in metabolic diseases. In addition, gene polymorphism in ABC transporters has been reported to be a risk factor for metabolic diseases, and it has been reported that relevant miRNAs have significant roles in regulating ABC transporters. In this review, we integrate recent studies to examine the roles of ABC transporters in metabolic diseases and aim to build a network with ABC transporters as the core, linking their transport abilities with metabolic and other diseases.

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“…These are membrane-associated proteins that transport various molecules across extra- and intra-cellular membranes, and can expel drugs from the interior of the cell [101]. Indeed, increased ABCA1 expression has been previously observed to play a role in therapeutic resistance in other types of cancers [102, 103]. Thus, among other changes, the significant increase in ABCA1 expression observed in molm-13 R2 cells is consistent with the slow drug uptake predicted by the mathematical model.…”

Section: Resultsmentioning

confidence: 99%

A mean-field approach for modeling the propagation of perturbations in biochemical reaction networks

Przedborski

Sharon

Chan

et al. 2021

Preprint

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Often, the time evolution of a biochemical reaction network is crucial for determining the effects of combining multiple pharmaceuticals. Here we illustrate a mathematical framework for modeling the dominant temporal behaviour of a complicated molecular pathway or biochemical reaction network in response to an arbitrary perturbation, such as resulting from the administration of a therapeutic agent. The method enables the determination of the temporal evolution of a target protein as the perturbation propagates through its regulatory network. The mathematical approach is particularly useful when the experimental data that is available for characterizing or parameterizing the regulatory network is limited or incomplete. To illustrate the method, we consider the examples of the regulatory networks for the target proteins c-Myc and Chop, which play an important role in venetoclax resistance in acute myeloid leukemia. First we show how the networks that regulate each target protein can be reduced to a mean-field model by identifying the distinct effects that groups of proteins in the regulatory network have on the target protein. Then we show how limited proteinlevel data can be used to further simplify the mean-field model to pinpoint the dominant effects of the network perturbation on the target protein. This enables a further reduction in the number of parameters in the model. The result is an ordinary differential equation model that captures the temporal evolution of the expression of a target protein when one or more proteins in its regulatory network have been perturbed. Finally, we show how the dominant effects predicted by the mathematical model agree with RNA sequencing data for the regulatory proteins comprising the molecular network, despite the model not having a priori knowledge of this data. Thus, while the approach gives a simplified model for the expression of the target protein, it allows for the interpretation of the effects of the perturbation on the regulatory network itself. This method can be easily extended to sets of target proteins to model components of a larger systems biology model, and provides an approach for partially integrating RNA sequencing data and protein expression data. Moreover, it is a general approach that can be used to study drug effects on specific protein(s) in any disease or condition.

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ATP‑binding cassette transporter A1: A promising therapy target for prostate cancer (Review)

Cited by 13 publications

References 57 publications

ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer

ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer

The impact of ATP-binding cassette transporters on metabolic diseases

A mean-field approach for modeling the propagation of perturbations in biochemical reaction networks

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