Atosiban improves the outcome of embryo transfer. A systematic review and meta-analysis of randomized and non-randomized trials

Abstract

Objective: To estimate the effectiveness of Atosiban in improving the outcome after embryo transfer. The effectiveness of embryo transfer per cycle is still relatively low. One possible explanation might be uterine contractility that expels the transferred embryos. Atosiban improved the outcome of embryo transfer by reducing uterine contractility. Methods: Data sources: A systematic review of papers in English using MEDLINE and EMBASE (1990-2019). Search terms included Atosiban, embryo transfer. Study selection: We included studies that compared the outcomes of embryo transfer with Atosiban and a control group. Data Extracting: Independent extraction of papers by two authors, using predefined data fields, including study quality indicators. Results: All pooled analyses were based on a fixed-effect model. Four randomised controlled trials, including 1,025 women, and two non-randomised trials, including 686 patients, met our inclusion criteria. In both studies, the heterogeneity was moderate. Atosiban increased clinical pregnancy rates regardless of the indication for ART or type of embryo transferred. Pooled OR in randomized controlled trials reached 1.47 (1.18-1.82), and in non-randomised controlled trials it reached 1.50 (95% CI 1.10-2.05) Conclusion: Atosiban appears to increase the clinical pregnancy rates in women undergoing embryo transfer.

Effect of administration of atosiban at day of embryo transfer on in-vitro fertilization out come

“…Around 15% were detected in the vagina following ET [1] . The results of our research that Atosiban was related with better ART cycle outcomes, which may have therapeutic implications, are corroborated by Schwarze et al [6] . Atosiban enhances uterine receptivity in women undergoing embryo transfer by inhibiting the oxytocin and vasopressin V1a receptors.…”

Is oxytocin receptor antagonist administration around embryo transfer associated with IVF treatment success? A systematic review and meta-analysis

“…For atosiban, a previous SR and meta-analysis reported an increased likelihood of a clinical pregnancy with moderate between study heterogeneity, however with inclusion of observational studies (Schwarze et al, 2020). The present meta-analysis focuses on RCTs only and adds with respect to atosiban the study of Yuan et al, 2019.…”

“…The utilization of atosiban around embryo transfer has been reported for the first time in the literature within a case report on an implantation failure patient (Pierzynski et al, 2007) and has later been investigated by a number of clinical studies. A systematic review and meta-analysis including four RCTs and two observational studies suggested an association of atosiban administration with improved IVF-outcomes (Schwarze et al, 2020). As an alternative to atosiban, the OTR-a barusiban has been developed for subcutaneous administration (Bosch et al, 2019).…”

Efficacy of atosiban for repeated embryo implantation failure: A systematic review and meta-analysis

“…There were some previous systematic reviews and metaanalyses (43)(44)(45) published about the use of atosiban in IVF treatment, but not for patients with RIF. They concluded that in the majority of women who experienced IVF, atosiban might only have a little impact on pregnancy outcomes.…”