Atorvastatin therapy in hypercholesterolemic patients suppresses cellular uptake of oxidized-LDL by differentiating monocytes

Pitavastatin Enhanced Lipoprotein Lipase Expression in 3T3-L1 Preadipocytes

“…Precise analysis showed that the inhibition of early cardiac events is not only due to the LDL-lowering effect (14), but also due to anti-atherogenic effects, such as the improvement of endotherial cells (15), anti-inflammatory effects (16), suppression of the migration and proliferation of smooth muscle cells (SMCs) (17), induction of the apoptosis of SMCs (18), and suppression of the cellular uptake of oxidized-LDL by monocytes. (19) The mechanism by which statins reduce serum triglyceride (TG) level is not controversial. It is considered that the TG-lowering effect was due to a reduction in the synthesis of very low-density lipoprotein (VLDL) in the liver (20)(21)(22).…”

Atorvastatin Downregulates Monocyte CD36 Expression, Nuclear NFκB and TNFα Levels in Type 2 Diabetes

“…Thus, lovastatin decreased the expression of CD36 mRNA during the early stages of the differentiation of these cells into macrophages, pitavastatin reduced CD36 surface protein expression in a human monocyte cell line (THP1 cells) and in human monocyte-derived macrophages, isolated from healthy donors 14,15) . Finally, atorvastatin treatment for one month decreased the CD36 gene expression in a culture of differentiating monocytes from hypercholesterolemic patients 16) . The molecular mechanism by which statins decrease CD36 cellular expression remains to be fully clarified.…”

CD36: Implications in cardiovascular disease

“…Most statins apparently down regulate CD36 expression, and this may contribute to their efficacy (Pietsch, Erl, & Lorenz, 1996,Fuhrman, Koren, Volkova, Keidar, Hayek, Aviram, 2002,Han, Zhou, Yokoyama, Hajjar, Gotto, & Nicholson, 2004,Puccetti, Sawamura, Pasqui, Pastorelli, Auteri, & Bruni, 2005,Ruiz-Velasco, Dominguez, & Vega, 2004. HIV protease inhibitors up regulate CD36 in male mice and increase atherosclerosis (Dressman, et al, 2003), but have an opposite effect in female mice (Allred, Smart, & Wilson, 2006).…”