2012
DOI: 10.5897/ajpp11.615
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Atorvastatin modulates constitutive and lipopolysaccharide induced IL-6 secretion in precursors of human skeletal muscle

Abstract: It is well documented that, besides reducing blood LDL lipoproteins, HMG-CoA reductase inhibitors (statins) also suppress inflammatory markers and improve survival in sepsis. These beneficial effects can be at least partly explained by their capacity to inhibit the release of IL-6, which is generally regarded as a proinflammatory cytokine, although a variety of other actions including anti-inflammatory have been reported for this cytokine under various circumstances. In quantitative terms, IL-6 release is a ma… Show more

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Cited by 4 publications
(2 citation statements)
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“…We hypothesize that after inhibition of the blood AChE by neostigmine, increasing level of blood acetylcholine activates the cholinergic anti-inflammatory pathway. Though we have no direct evidence of neostigmine implication in the cholinergic anti-inflammatory pathway, the proved decreases of IFN-and IL-6 in an indirectly proportionally dose response manner confirm the hypothesis when immunological meaning of the markers is considered (Golicnik et al, 2012). Aggravated mortality in course of tularemia is another plausible proof confirming the hypothesis as well.…”
Section: Discussionsupporting
confidence: 47%
“…We hypothesize that after inhibition of the blood AChE by neostigmine, increasing level of blood acetylcholine activates the cholinergic anti-inflammatory pathway. Though we have no direct evidence of neostigmine implication in the cholinergic anti-inflammatory pathway, the proved decreases of IFN-and IL-6 in an indirectly proportionally dose response manner confirm the hypothesis when immunological meaning of the markers is considered (Golicnik et al, 2012). Aggravated mortality in course of tularemia is another plausible proof confirming the hypothesis as well.…”
Section: Discussionsupporting
confidence: 47%
“…All donors gave their written informed consent. Preparation of primary culture of human skeletal muscle cells was performed as previously described [3134]. Briefly, muscle samples were cleaned of connective and adipose tissue, cut into small pieces, and then trypsinised for 30 minutes in Earle's Balanced Salt Solution supplemented with trypsin-EDTA at 37°C.…”
Section: Methodsmentioning
confidence: 99%