Atorvastatin lowers lipoprotein(a) but not apolipoprotein(a) fragment levels in hypercholesterolemic subjects at high cardiovascular risk

A prospective study of lipoprotein(a) and risk of coronary heart disease among women with type 2 diabetes

“…Optimisation of glycaemic control does not affect serum Lp(a) levels in patients with type 2 diabetes [31]; most of the cholesterol-lowering drugs are targeted to LDL-c and are less effective against Lp(a) [32]. Favourable effects on Lp(a) levels have been suggested for fish intake [33], the use of nicotinic acid [34] and the use of oestrogen or testosterone [35].…”

Effect of statins on lipoprotein (a) in dyslipidemic patients

“…Gonbert et al (2002) performed a large cohort study, which showed a significant decrease in the Lp(a) concentration, after a 6 weeks monotherapy of atorvastatin and simvastatin. 24 In this clinical study, the 12 weeks monotherapies of atorvastatin and simvastatin have shown a similar decrease in Lp(a) concentration. At the same time, rosuvastatin monotherapy has shown to elevate the Lp(a) levels substantially.…”

Effects of Ezetimibe on Remnant-Like Particle Cholesterol, Lipoprotein (a), and Oxidized Low-Density Lipoprotein in Patients with Dyslipidemia

“…No specific Lp(a)-lowering agents have been discovered. The effect of statins on Lp(a) is controversial, although some studies have demonstrated that statins can reduce the Lp(a) level 17) . In the present study, the median level of Lp(a) was decreased by 29% due to ezetimibe monotherapy.…”

“…Increased levels of remnant-like particle (RLP)-C 12) , lipoprotein (a) [Lp(a)] 13) , and oxidized LDL (Ox-LDL) 14) have been recognized as risk factors for CAD. RLP-C 15,16) and Ox-LDL 16) are both decreased by statin therapy; however, the effect of statin therapy on Lp(a) is controversial, although some studies have demonstrated that statins can reduce the Lp(a) level 17) . It also remains unclear whether ezetimibe can reduce the levels of RLP-C, Lp(a), and Ox-LDL.…”