Atorvastatin-loaded emulsomes foam as a topical antifungal formulation

Eita, Alaa S.; Makky, Amna M. A.; Anter, Asem; Khalil, Islam A.

doi:10.1016/j.ijpx.2022.100140

Cited by 3 publications

(4 citation statements)

References 78 publications

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“…20,23 However, because of the many side effects associated with systemic statins and the drug-drug interactions between systemic statins and antifungals, it was appealing to investigate the antifungal efficacy of topical statins. Topical treatment requires the right vehicle to be delivered efficiently; the ones found to be effective were the emulgels containing the statin of choice 31 and statin emulsomes loaded into a foam system. 36 Topical statins were found to be efficient against oral and vaginal candidiasis, skin Candida albicans, Sporotrichosis, and Malassezia spp.…”

Section: Discussionmentioning

confidence: 99%

“…Another study, conducted by Eita et al 31 in 2022, studied the treatment of rats infected with Candida albicans using a modified form of the emulgel: the foam vehicle. Foams have recently been gaining popularity as the vehicles of preference in skin therapy.…”

Section: Topical Statinsmentioning

confidence: 99%

“…Another study, conducted by Eita et al 31 . in 2022, studied the treatment of rats infected with Candida albicans using a modified form of the emulgel: the foam vehicle.…”

Section: Clinical Applicationsmentioning

confidence: 99%

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Topical statins as antifungals: a review

Khoury,

Ghaoui,

El Tayar

et al. 2024

Int J Dermatology

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Cutaneous fungal infections affect millions around the world. However, severe, multi‐resistant fungal infections are increasingly being reported over the past years. As a result of the high rate of resistance which urged for drug repurposing, statins were studied and found to have multiple pleiotropic effects, especially when combined with other already‐existing drugs. An example of this is the synergism found between several typical antifungals and statins, such as antifungals Imidazole and Triazole with a wide range of statins shown in this review. The main mechanisms in which they exert an antifungal effect are ergosterol inhibition, protein prenylation, mitochondrial disruption, and morphogenesis/mating inhibition. This article discusses multiple in vitro studies that have proven the antifungal effect of systemic statins against many fungal species, whether used alone or in combination with other typical antifungals. However, as a result of the high rate of drug–drug interactions and the well‐known side effects of systemic statins, topical statins have become of increasing interest. Furthermore, patients with dyslipidemia treated with systemic statins who have a new topical fungal infection could benefit from the antifungal effect of their statin. However, it is still not indicated to initiate systemic statins in patients with topical mycotic infections if they do not have another indication for statin use, which raises the interest in using topical statins for fungal infections. This article also tackles the different formulations that have been studied to enhance topical statins' efficacy, as well as the effect of different topical statins on distinct dermatologic fungal diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Topical Statinsmentioning

confidence: 99%

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Topical statins as antifungals: a review

Khoury,

Ghaoui,

El Tayar

et al. 2024

Int J Dermatology

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“…The concept of repurposing involves exploring alternative therapeutic applications for drugs that have already been approved for different uses. In other words, it involves finding new ways to utilize previously authorized medications [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

The Exploitation of pH-Responsive Eudragit-Coated Mesoporous Silica Nanostructures in the Repurposing of Terbinafine Hydrochloride for Targeted Colon Cancer Inhibition: Design Optimization, In Vitro Characterization, and Cytotoxicity Assessment

Alyami,

Musallam,

Ibrahim

et al. 2023

Pharmaceutics

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Targeted drug delivery is achieving great success in cancer therapy due to its potential to deliver drugs directly to the action site. Terbinafine hydrochloride (TER) is a broad-spectrum anti-fungal drug that has been found to have some potential anti-tumor effects in the treatment of colon cancer. We aimed here to design and develop pH-sensitive Eudragit (Eud)-coated mesoporous silica nanostructures (MSNs) to control drug release in response to changes in pH. The diffusion-supported loading (DiSupLo) technique was applied for loading TER into the MSNs. The formulation was optimized by a D-optimal design, which permits the concurrent assessment of the influence of drug/MSN%, coat concentration, and MSN type on the drug entrapment efficiency (EE) and its release performance. The optimal formula displayed a high EE of 96.49%, minimizing the release in pH 1.2 to 16.15% and maximizing the release in pH 7.4 to 78.09%. The cytotoxicity of the optimal formula on the colon cancer cells HT-29 was higher than it was with TER alone by 2.8-fold. Apoptosis in cancer cells exposed to the optimum formula was boosted as compared to what it was with the plain TER by 1.2-fold and it was more efficient in arresting cells during the G0/G1 and S stages of the cell cycle. Accordingly, the repurposing of TER utilizing Eud/MSNs is a promising technique for targeted colon cancer therapy.

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