Atorvastatin Inhibits High-Fat Diet-Induced Lipid Metabolism Disorders in Rats by Inhibiting Bacteroides Reduction and Improving Metabolism

Li, Huimin; Wang, Shue; Wang, Shuai; Yu, Hai; Yu, Wenhao; Ma, Xiaomin; He, Xiaodong

doi:10.2147/dddt.s379335

Cited by 3 publications

(5 citation statements)

References 51 publications

(64 reference statements)

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“…Patients with mental disorders often have a variety of sleep problems, such as sleep interruptions and a reduced duration of sleep ( Baglioni et al, 2016 ). Both Dialister related to carbohydrate metabolism ( Gonçalves et al, 2016 ) and Bacteroides related to fat metabolism ( Li et al, 2022 ) were increased in the intestinal tract of adolescents who slept longer, which might be the reason for the different distribution of intestinal microbiota in adolescents with different sleep duration. Given that adolescents are in a critical period of growth and development, a balanced diet could not only help in maintaining a stable intestinal microbiota but also promote a healthy psychological state and improve sleep quality.…”

Section: Discussionmentioning

confidence: 99%

Effects of urbanization and lifestyle habits on the intestinal microbiota of adolescents in eastern China

Zhao

Xie

et al. 2023

Front. Microbiol.

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IntroductionOwing to urbanization, living habits have changed widely, leading to alterations in the intestinal microbiota of urban residents. However, there are few studies on the characteristics of intestinal microbiota of adolescents living in different urbanized areas in China.MethodsA total of 302 fecal samples collected from adolescent students in eastern China were examined. 16S rRNA high-throughput sequencing was used to identify the fecal microbiota. These data were combined with questionnaire survey results to investigate the effect of urbanization on the intestinal microbiota of adolescents in eastern China. Moreover, the role of lifestyle habits in this relationship was also evaluated.ResultsThe results revealed significant differences in the structure of the intestinal microbiota among adolescents living in regions with different levels of urbanization. Adolescents living in urban regions had a significantly higher proportion of Bacteroides (p < 0.001, FDR = 0.004), whereas those living in towns and rural regions had higher proportions of Bifidobacterium (p < 0.001, FDR < 0.001) and Prevotella (p < 0.05, FDR = 0.019). The diversity of the intestinal microbiota was higher in urban residents than in adolescents living in towns and rural regions (p < 0.05). In addition, the differences in intestinal microbiota across individuals living in cities, towns, and rural regions were related to dietary preferences, flavor preferences, and sleep and exercise durations. Adolescents who ate more meat had more Dorea (LDA = 3.622, p = 0.04), while the abundance of Escherichia–Shigella is higher among adolescents who ate more condiments (LDA = 4.285, p = 0.02). The abundance of Dialister was significantly increased in adolescents with longer sleep durations (LDA = 4.066, p = 0.03). Adolescents who exercised for a long duration had more Faecalibacterium than those who exercised for a shorter duration (LDA = 4.303, p = 0.04).DiscussionOur research has preliminarily demonstrated that there were differences in the composition of Gut microbiome in stool samples of adolescents living in different urbanized areas, and provide a scientific basis for the maintenance of a healthy intentional microbota in adolescences.

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Section: Discussionmentioning

confidence: 99%

Effects of urbanization and lifestyle habits on the intestinal microbiota of adolescents in eastern China

Zhao

Xie

et al. 2023

Front. Microbiol.

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“…In recent years, various effective drugs, such as glucose-lowering drugs, antioxidants, lipid-lowering agents, and natural bile acid treatments, have been used to treat NAFLD ( Mantovani and Dalbeni, 2021 ). Interestingly, gut microbiota analysis has shown an increase in Bacteroides abundance after treatment with Raw Bowl Tea polyphenols, atorvastatin, Ganoderma meroterpene derivative, and the prebiotic inulin for NAFLD ( Liu et al, 2019 ; Qiao et al, 2020 ; Aoki et al, 2021 ; Li H. et al, 2022 ). For instance, atorvastatin was found to reduce lipid levels, improve HFD-induced hepatic steatosis, and increase Bacteroides abundance ( Li H. et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, gut microbiota analysis has shown an increase in Bacteroides abundance after treatment with Raw Bowl Tea polyphenols, atorvastatin, Ganoderma meroterpene derivative, and the prebiotic inulin for NAFLD ( Liu et al, 2019 ; Qiao et al, 2020 ; Aoki et al, 2021 ; Li H. et al, 2022 ). For instance, atorvastatin was found to reduce lipid levels, improve HFD-induced hepatic steatosis, and increase Bacteroides abundance ( Li H. et al, 2022 ). In fa/fa rats, the oral administration of Ganoderma meroterpene derivative was shown to reduce de novo lipogenesis, reverse non-alcoholic hepatic steatosis, and enhance Bacteroides abundance ( Qiao et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Bacteroides have been found to significantly modulate lipid metabolism in animal models ( Lee et al, 2021 ; López-Almela et al, 2021 ; Li H. et al, 2022 ; Xu et al, 2023 ). These studies indicate that Bacteroides ultimately reduce the accumulation of fat in the liver via inhibiting SREBP-1 and ChREBP expression, as well as related adipogenic genes, and by promoting FAO-related pathways.…”

Section: Introductionmentioning

confidence: 99%

“…In vivo evidence for Bacteroides Strain in the treatment of NAFLD -Almela et al, 2021;Li H. et al, 2022;Xu et al, 2023)…”

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Bacteroides and NAFLD: pathophysiology and therapy

Zhang,

Zhou,

et al. 2024

Front. Microbiol.

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Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition observed globally, with the potential to progress to non-alcoholic steatohepatitis (NASH), cirrhosis, and even hepatocellular carcinoma. Currently, the US Food and Drug Administration (FDA) has not approved any drugs for the treatment of NAFLD. NAFLD is characterized by histopathological abnormalities in the liver, such as lipid accumulation, steatosis, hepatic balloon degeneration, and inflammation. Dysbiosis of the gut microbiota and its metabolites significantly contribute to the initiation and advancement of NAFLD. Bacteroides, a potential probiotic, has shown strong potential in preventing the onset and progression of NAFLD. However, the precise mechanism by which Bacteroides treats NAFLD remains uncertain. In this review, we explore the current understanding of the role of Bacteroides and its metabolites in the treatment of NAFLD, focusing on their ability to reduce liver inflammation, mitigate hepatic steatosis, and enhance intestinal barrier function. Additionally, we summarize how Bacteroides alleviates pathological changes by restoring the metabolism, improving insulin resistance, regulating cytokines, and promoting tight-junctions. A deeper comprehension of the mechanisms through which Bacteroides is involved in the pathogenesis of NAFLD should aid the development of innovative drugs targeting NAFLD.

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The Application of Metabolomics in Hyperlipidemia: Insights into Biomarker Discovery and Treatment Efficacy Assessment

Alwahsh,

Alejel,

Hasan

et al. 2024

Metabolites

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Hyperlipidemia is a lipid metabolism disorder that refers to increased levels of total triglycerides (TGs), cholesterol (TC), and low-density lipoprotein-cholesterol (LDL-C) and decreased levels of high-density lipoprotein-cholesterol (HDL-C). It is a major public health issue with increased prevalence and incidence worldwide. The ability to identify individuals at risk of this disorder before symptoms manifest will facilitate timely intervention and management to avert potential complications. This can be achieved by employing metabolomics as an early detection method for the diagnostic biomarkers of hyperlipidemia. Metabolomics is an analytical approach used to detect and quantify metabolites. This provides the ability to explain the metabolic processes involved in the development and progression of certain diseases. In recent years, interest in the use of metabolomics to identify disease biomarkers has increased, and several biomarkers have been discovered, such as docosahexaenoic acid, glycocholic acid, citric acid, betaine, and carnitine. This review discusses the primary metabolic alterations in the context of hyperlipidemia. Furthermore, we provide an overview of recent studies on the application of metabolomics to the assessment of the efficacy of traditional herbal products and common lipid-lowering medications.

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Atorvastatin Inhibits High-Fat Diet-Induced Lipid Metabolism Disorders in Rats by Inhibiting Bacteroides Reduction and Improving Metabolism

Cited by 3 publications

References 51 publications

Effects of urbanization and lifestyle habits on the intestinal microbiota of adolescents in eastern China

Effects of urbanization and lifestyle habits on the intestinal microbiota of adolescents in eastern China

Bacteroides and NAFLD: pathophysiology and therapy

The Application of Metabolomics in Hyperlipidemia: Insights into Biomarker Discovery and Treatment Efficacy Assessment

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