Atorvastatin Improves Endothelial Function and Cardiac Performance in Patients with Dilated Cardiomyopathy: The Role of Inflammation

Liu, Miao; Wang, Fang; Wang, Yanrong; Jin, Runming

doi:10.1007/s10557-009-6186-3

Cited by 44 publications

(21 citation statements)

References 27 publications

(27 reference statements)

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“…Dilated cardiomyopathy (DCM) [1,2] is a primary chronic myocardial disease manifesting with systolic dysfunction which is not due to pericardial disease, coronary artery disease, hypertension, congenital heart disease, or valvular heart disease [3]. The diagnosis of DCM requires excluding the above listed etiologic factors.…”

Section: Introductionmentioning

confidence: 99%

Efekty leczenia atorwastatyną chorych w średnim wieku z zaawansowaną kardiomiopatią rozstrzeniową — prospektywne randomizowane badanie jednoośrodkowe

2017

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Section: Introductionmentioning

confidence: 99%

Efekty leczenia atorwastatyną chorych w średnim wieku z zaawansowaną kardiomiopatią rozstrzeniową — prospektywne randomizowane badanie jednoośrodkowe

2017

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“…Myocardial infarction (MI) is a common presentation of CVD (Liu et al 2009). Some clinical trials established the benefits of statins after MI.…”

Section: Introductionmentioning

confidence: 99%

“…Statins were reported to improve the endothelial function by mechanisms that are unrelated to a cholesterol-lowering effect. Some of these mechanisms involve prevention of inflammation, down-regulation of systemic inflammatory responses (Liu et al 2009) and induction of angiogenesis (Hamelin and Turgeon 1998). In a previous study, therapy with pravastatin was found to decrease the risk of recurrent coronary events after MI in patients with average cholesterol levels; this outcome may have resulted in part from anti-inflammatory as well as lipid-lowering properties of the drug (Ridker et al 1998).…”

Section: Introductionmentioning

confidence: 99%

Bone marrow mononuclear cells enhance anti-inflammatory effects of pravastatin against isoproterenol-induced myocardial infarction in rats

El-Mahdy

Salem

El-Sayad

et al. 2015

Journal of Immunotoxicology

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The current study investigated the combinatorial effect of pravastatin (PRAV) and bone marrow mononuclear cells (BM-MNC) on acute myocardial infarction (AMI) induced experimentally in rats. After induction of MI, rats were given oral PRAV (20 mg/kg/day) for 28 days or a bolus intravenous injection (via lateral vein) of a total of 14 Â 10 6 autologous BM-MNC or a combination of both. Serum brain natriuretic peptide (BNP) and histologic changes in cardiac tissues were assessed. Cardiac contents of lipid peroxides, superoxide dismutase (SOD) and inflammatory biomarkers including tumor necrosis factor (TNF)-and interleukin (IL)-1 as well as vascular endothelial growth factor (VEGF) and nitric oxide (NO) were also measured. Combined PRAV and BM-MNC treatment significantly suppressed serum BNP. Cardiac cell apoptosis and inflammatory cell infiltration in heart tissue decreased significantly in both the PRAV and the PRAV + BM-MNC groups. Cardiac lipid peroxides along with TNF and IL-1 levels were significantly reduced in both the PRAV and PRAV + BM-MNC hosts with an increase in SOD levels. However, the combined treatment increased cardiac NO levels and did not modify cardiac VEGF levels. The current results indicated that administration of BM-MNC improved the therapeutic efficacy of PRAV treatment by improving the morphology of infarcted hearts as well as decreasing inflammation in a host, but did not do so by inducing therapeutic angiogenesis. ARTICLE HISTORY

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“…Aumento de sICAM-1 pode ser uma consequência indireta de danos do tecido ou da inflamação (TEPPO et al, 2001). Em indivíduos sem manifestações clínicas de patologia cardiovascular, a sICAM-1 parece ser o melhor marcador de lesão endotelial (LIU et al, 2009).…”

Section: Introductionunclassified

Análise Da Concentração De Sicam-1 Em Crianças E Adolescentes Com Processo Inflamatório Com Desvio Nuclear À Esquerda

Peliser¹,

Merisio²

2015

Arq. Ciênc. Saúde Unipar

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PELISER, N. C.; MERISIO, P. R. Análise da concentração de SICAM-1 em crianças e adolescentes com processo inflamatório com desvio nuclear à esquerda. Arq. Cienc. Saúde UNIPAR, Umuarama, v. 19, n. 2, p, 89-93, maio/ago. 2015 RESUMO: Os neutrófilos são fagócitos e atuam no processo de defesa do organismo iniciando a cascata inflamatória quando ativados. Este processo envolve vários fatores, entre eles a liberação de bastonetes e o aumento na concentração de sICAM-1. Verificou-se o estado de ativação do endotélio em 37 pacientes de 0 a 18 anos sem doenças crônicas, de modo a investigar um possível aumento de sICAM-1 com o aumento de bastonetes. Os bastonetes foram analisados por meio de verificação de prontuário. A determinação das concentrações séricas de sICAM-1 foi realizada por meio da técnica imunoenzimática (ELISA) direto. Foi possível notar que não há correlação entre o aumento de bastonete e o aumento da molécula sICAM-1 (r=0,28). Dividindo-se os pacientes em dois grupos, um que possui sICAM-1 alterado e outro que possui sICAM-1 normal, observou-se mediante os dados que estes possuem diferença notável de bastonetes (p=0,047), onde a média de bastonetes é maior no grupo sICAM-1 alterado. A presença de sICAM-1 aumentada, normalmente, está ligada a casos inflamatórios, mas a mudança na sua expressão pode sofrer influência de outros fatores, tais como o uso de anti-inflamatórios esteroidais e tabagismo. Uma possível explicação para não ter ocorrido o aumento de sICAM-1 nos pacientes estudados, é de que estes estejam utilizando medicamentos do tipo anti-inflamatórios esteroidais. Segundo a literatura, a sICAM-1 parece ser um bom marcador para lesão endotelial em pacientes com doenças cardiovasculares, sugere-se então um estudo mais aprofundado para estes casos. PALAVRAS-CHAVES: Neutrófilos. Endotélio. ELISA. ANALYSIS OF sICAM-1 CONCENTRATION IN CHILDREN AND TEENS WITH INFLAMMATORY PROCESS WITH NUCLEAR SHIFT TO THE LEFT ABSTRACTS:Neutrophils are phagocytes and act in the body's defense process initiating the inflammatory cascade when activated. This process involves several factors, including the release of band cells and the increase in the concentration of sICAM-1. The activation state of the endothelium in 37 patients from 0 to 18 years old with no chronic diseases was checked, in order to investigate a possible increase of sICAM-1 with increased band cells. The band cells were analyzed through an investigation of medical records. Determination of sI-CAM-1 serum concentrations was performed by direct enzyme immunoassay (ELISA). No correlation between the increase in band cells and increase the sICAM-1 molecule (r = 0.28) could be observed. By dividing the patients into two groups, one with changed sICAM-1 and the other presenting standard sICAM-1, it could be observed by the data they have notable difference in band cells (p = 0.047), where the average number of band cells is greater in the group with altered sICAM-1. The presence of increased sICAM-1 is typically linked to inflammatory cases, but the chang...

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Atorvastatin Improves Endothelial Function and Cardiac Performance in Patients with Dilated Cardiomyopathy: The Role of Inflammation

Cited by 44 publications

References 27 publications

Efekty leczenia atorwastatyną chorych w średnim wieku z zaawansowaną kardiomiopatią rozstrzeniową — prospektywne randomizowane badanie jednoośrodkowe

Efekty leczenia atorwastatyną chorych w średnim wieku z zaawansowaną kardiomiopatią rozstrzeniową — prospektywne randomizowane badanie jednoośrodkowe

Bone marrow mononuclear cells enhance anti-inflammatory effects of pravastatin against isoproterenol-induced myocardial infarction in rats

Análise Da Concentração De Sicam-1 Em Crianças E Adolescentes Com Processo Inflamatório Com Desvio Nuclear À Esquerda

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