Abstract:The effect of atorvastatin on digoxin pharmacokinetics was assessed in 24 healthy volunteers in two studies. Subjects received 0.25 mg digoxin daily for 20 days, administered alone for the first 10 days and concomitantly with 10 mg or 80 mg atorvastatin for the last 10 days. Mean steady‐state plasma digoxin concentrations were unchanged by administration of 10 mg atorvastatin. Mean steady‐state plasma digoxin concentrations following administration of digoxin with 80 mg atorvastatin were slightly higher than c… Show more
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