Atorvastatin Can Modulate DNA Damage Repair in Endothelial Cells Exposed to Mitomycin C

Sinitsky, M. Yu.; Asanov, Maxim А.; Цепокина, А. В.; Шишкова, Д. К.; Khutornaya, M. V.; Минина, В. И.; Понасенко, А. В.

doi:10.3390/ijms24076783

Cited by 4 publications

(3 citation statements)

References 83 publications

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“…This task requires large amounts of ATP to rearrange the intercellular junctions and maintain intracellular Ca 2+ metabolism, which is also indispensable for the enzymatic digestion and biosynthesis of nitric oxide and prostacyclin, the potent vasodilators [121][122][123][124]. With regards to nucleotide metabolism, DNA repair defects have been associated with age-related and premature endothelial dysfunction which develops as reduced nitric oxide release and chronic low-grade inflammation [125][126][127][128][129][130][131]. The same has been reported for decreased ubiquitination and impaired autophagy, as removal of dysfunctional organelles, supramolecular complexes, and molecules also becomes compromised with age [132][133][134], and ubiquitination participates in regulating rearrangements of intercellular junctions and integrity of the endothelial barrier [135,136].…”

Section: Discussionmentioning

confidence: 99%

Multi-Omics Profiling of Human Endothelial Cells from the Coronary Artery and Internal Thoracic Artery Reveals Molecular but Not Functional Heterogeneity

Frolov,

Lobov,

Kabilov

et al. 2023

IJMS

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Major adverse cardiovascular events occurring upon coronary artery bypass graft surgery are typically accompanied by endothelial dysfunction. Total arterial revascularisation, which employs both left and right internal thoracic arteries instead of the saphenous vein to create a bypass, is associated with better mid- and long-term outcomes. We suggested that molecular profiles of human coronary artery endothelial cells (HCAECs) and human internal mammary artery endothelial cells (HITAECs) are coherent in terms of transcriptomic and proteomic signatures, which were then investigated by RNA sequencing and ultra-high performance liquid chromatography-mass spectrometry, respectively. Both HCAECs and HITAECs overexpressed molecules responsible for the synthesis of extracellular matrix (ECM) components, basement membrane assembly, cell-ECM adhesion, organisation of intercellular junctions, and secretion of extracellular vesicles. HCAECs were characterised by higher enrichment with molecular signatures of basement membrane construction, collagen biosynthesis and folding, and formation of intercellular junctions, whilst HITAECs were notable for augmented pro-inflammatory signaling, intensive synthesis of proteins and nitrogen compounds, and enhanced ribosome biogenesis. Despite HCAECs and HITAECs showing a certain degree of molecular heterogeneity, no specific markers at the protein level have been identified. Coherence of differentially expressed molecular categories in HCAECs and HITAECs suggests synergistic interactions between these ECs in a bypass surgery scenario.

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Section: Discussionmentioning

confidence: 99%

Multi-Omics Profiling of Human Endothelial Cells from the Coronary Artery and Internal Thoracic Artery Reveals Molecular but Not Functional Heterogeneity

Frolov,

Lobov,

Kabilov

et al. 2023

IJMS

Self Cite

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show abstract

“…Statins are widely used, but atropostatin(Atv) administration leads to oxidative stress and cellular damage. 213 Indicators of ferroptosis, such as iron overload, ROS accumulation, and lipid peroxidation, were observed in Atvtreated muscle cells, especially in the mitochondria of the cells. 214 One study reported that simvastatin causes ferroptosis in cancer cells by inhibiting HMGCR expression.…”

Section: Othersmentioning

confidence: 98%

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Luo,

Bai,

Zhang

et al. 2024

DDDT

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“…(Veerabhadrappa et al, 2021). Atorvastatin can modulate the DNA damage repair response in primary human endothelial cells exposed to MMC in a cell line-and incubation scheme-dependent manner (Sinitsky et al, 2023).…”

Section: Dna Fragmentation Percentmentioning

confidence: 99%

Evaluation of Antiproliferative activity of Taxol, Proanthocyanidin and Atorvastatin against human hepatocellular carcinoma cell line (HepG2).

maria,

Salim,

Abd El-Magid

2023

Benha Veterinary Medical Journal

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Liver cancer is the sixth most frequent cancer in the world, with a significant morbidity and mortality rate, is liver cancer. Discovery of a suitable therapeutic alternative for this disease is of greatest importance because various types of cancer annually result in thousands of fatalities worldwide. Atorvastatin is a competitive inhibitor of hydroxy methylglutaryl CoA reductase, which plays a role in anticancer activities in a range of malignancies, including human liver cancer. Proanthocynadin is a phytochemical that has a variety of pharmacological effects and chemotherapeutic properties. Taxol, an anti-microtubule chemotherapeutic medication, has been shown to be effective in the treatment of several HepG2 (liver carcinoma cell line). In this study, the antiproliferative and proapoptotic properties of Atorvastatin, Proanthocynadin and Taxol against HepG2 liver cancer cell line was evaluated in vitro. Cell survival and apoptosis in liver cancer cell lines were analyzed using MTT assay. The results showed that Taxol, Atorvastatin and Proanthcyanidin inhibited the viability of HepG2 cells in a time-and dosedependent manner, induced a significant enhancement of treated cancer cells compared to untreated cells.

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Atorvastatin Can Modulate DNA Damage Repair in Endothelial Cells Exposed to Mitomycin C

Cited by 4 publications

References 83 publications

Multi-Omics Profiling of Human Endothelial Cells from the Coronary Artery and Internal Thoracic Artery Reveals Molecular but Not Functional Heterogeneity

Multi-Omics Profiling of Human Endothelial Cells from the Coronary Artery and Internal Thoracic Artery Reveals Molecular but Not Functional Heterogeneity

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Evaluation of Antiproliferative activity of Taxol, Proanthocyanidin and Atorvastatin against human hepatocellular carcinoma cell line (HepG2).

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