Atorvastatin attenuates spinal cord injury by chronic fluorosis in rats

Shen, Qingshan; Cao, Yangjing; Yingpeng, Xia

doi:10.1097/wnr.0000000000001351

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…In acute SCI context, atorvastatin was evaluated in a 5 mg/kg dosage administered via oral gavage [148] and by intraperitoneal injection [149]. Atorvastatin revealed neuroprotective effects by decreasing biochemical markers of oxidative stress, mild glial cell infiltration, p53, and MMP-9, increasing spare axons [150], and upregulating MBP levels [151]. In addition, Haazza and colleagues also found atorvastatin to improve hindlimb function, sensory response to noxious stimuli, and placing/stepping reflex in a model of ischemia-reperfusion injury of the spinal cord.…”

Section: Molecular Therapymentioning

confidence: 99%

Pathophysiology and Therapeutic Approaches for Spinal Cord Injury

Lima

Monteiro

Salgado

et al. 2022

IJMS

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Spinal cord injury (SCI) is a disabling condition that disrupts motor, sensory, and autonomic functions. Despite extensive research in the last decades, SCI continues to be a global health priority affecting thousands of individuals every year. The lack of effective therapeutic strategies for patients with SCI reflects its complex pathophysiology that leads to the point of no return in its function repair and regeneration capacity. Recently, however, several studies started to uncover the intricate network of mechanisms involved in SCI leading to the development of new therapeutic approaches. In this work, we present a detailed description of the physiology and anatomy of the spinal cord and the pathophysiology of SCI. Additionally, we provide an overview of different molecular strategies that demonstrate promising potential in the modulation of the secondary injury events that promote neuroprotection or neuroregeneration. We also briefly discuss other emerging therapies, including cell-based therapies, biomaterials, and epidural electric stimulation. A successful therapy might target different pathologic events to control the progression of secondary damage of SCI and promote regeneration leading to functional recovery.

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