Atorvastatin Attenuates Endothelial Cell Injury in Atherosclerosis Through Inhibiting ACSL4‐Mediated Ferroptosis
Huilian Tan,
Ling Liu,
Yanchao Qi
et al.
Abstract:Objective: This study is aimed at investigating the effects of atorvastatin (ATV) on endothelial cell injury in atherosclerosis (AS) through inhibiting acyl‐CoA synthetase long‐chain family member 4 (ACSL4)‐mediated ferroptosis.Methods: Human umbilical vein endothelial cells (HUVECs) were treated with oxidized low‐density lipoprotein (ox‐LDL) to establish an in vitro model of AS. The cell viability, lactate dehydrogenase (LDH) release, apoptosis, and expression levels of apoptotic proteins were assessed. The l… Show more
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