Atopy Is Associated with Asthma in Adults Living in Rural and Urban Southwestern Nigeria

Ige, Olusoji Mayowa; Arinola, OG; Oluwole, Oluwafemi; Falade, A G; Falusi, Adeyinka G.; Aderemi, Toyin Janet; Huo, Dezheng; Olopade, OI; Olopade, Christopher O.

doi:10.3109/02770903.2011.608458

Cited by 5 publications

(6 citation statements)

References 40 publications

(48 reference statements)

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“…Overall, the factors that determine asthma in African communities remain controversial with conflicting reports about the role of atopy and parasitic infestations [31,32]. Atopy does not fully explain the distribution of asthma in urban and rural African communities, neither does parasitic load clearly define the divide between asthma in rural and urban communities in Nigeria [25,33]. As in many previous reports on the influence of gender on asthma prevalence and severity, we found that older women tend to report more asthma symptoms than men compared with younger age groups.…”

Section: Discussionmentioning

confidence: 97%

Low prevalence of asthma in sub Saharan Africa: A cross sectional community survey in a suburban Nigerian town

Obaseki

Awoniyi

Awopeju

et al. 2014

Respiratory Medicine

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Section: Discussionmentioning

confidence: 97%

Low prevalence of asthma in sub Saharan Africa: A cross sectional community survey in a suburban Nigerian town

Obaseki

Awoniyi

Awopeju

et al. 2014

Respiratory Medicine

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“…This may have resulted in wide confidence intervals and thus reduced power to detect a statistically significant difference. Some studies had small sample sizes and are likely to have been underpowered . Although the prevalence of SPT was generally higher in many investigations, its association with helminths was not consistent for reasons that are not well understood.…”

Section: Helminths and Reported Or Diagnosed Allergy‐related Outcomesmentioning

confidence: 99%

Parasites and allergy: Observations from Africa

Mpairwe

Amoah

2018

Parasite Immunology

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Population studies from the African continent have observed a marked increase in the prevalence of allergy-related diseases over the past few decades, but the cause of this rise is not fully understood. The most investigated potential risk factor has been the relationship between exposure to helminths and allergy-related outcomes. Immunologically, parallels exist between responses to helminths and to allergens as both are associated with elevated levels of immunoglobulin E, increased numbers of T helper 2 cells and other immune cells. However, epidemiological studies from the African continent have found inconsistent results. In this review, observations from population studies carried out in Africa over the last decade that focus on the relationship between helminth infections and allergy-related outcomes are examined. How these findings advance our understanding of the complex interactions between helminths and allergies at the population level is also explored as well as some of the underlying immune mechanisms involved. This knowledge is important for better diagnosis, treatment and prevention of allergy-related diseases and has wider global significance.

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“…Serum samples were frozen and stored at -80 0 C until analysis was performed. Samples were analyzed for white blood cells, IgE, hemoglobin phenotype, eosinophils and G6PD status as previously described 14 .…”

Section: Blood Samplementioning

confidence: 99%

“…Allergy skin testing Allergy skin test was performed using the Skintestor OMNI TM (Greer Laboratories, Inc., Lenoir, North Carolina) on the volar side of the forearm with standardized extracts of eight groups of allergens as we previously described 14 . Skin response was measured after 15 minutes, considering skin wheal diameter.…”

Section: Blood Samplementioning

confidence: 99%

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Allergy sensitization and asthma among 13-14 year old school children in Nigeria

Oluwole¹,

Arinola²,

Falade³

et al. 2013

Af Hlth Sci

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Background: The prevalence of asthma and role of atopy in asthma among children has not been clearly defined in Nigeria. Objective: To determine the prevalence of asthma and investigate risk factors related to allergy sensitization among urban and rural school children in southwest Nigeria. Methods: Validated ISAAC questionnaire was administered to 1736 high school children in randomly selected schools in rural and urban communities. Identified asthma cases were matched to controls. Allergy skin tests, blood eosinophil count, serum IgE and stool examination for parasites were performed. Dust samples from homes were also collected and analyzed for allergens. Results: The prevalence of asthma was 7.5% (95% CI 6.0 to 9.2%) and 8% (95% CI 6.0-10.4%) in the rural and urban communities respectively . Risk factors for asthma included cigarette-smoking, cats in the home and family size. Eosinophil count (109/L) was elevated in asthmatics [0.70 (95% CI 0.48-1.11) vs. 0.32 (95% CI 0.19-0.69); p<0.01], but IgE levels were similar between the two groups (298±229 IU/mL vs. 288±257; p=0.97). Positive skin tests to cat hair, cockroach, mango blossom and mouse epithelium were more frequent in asthmatics than in healthy controls, especially in the rural communities. There was no correlation between allergens in dust collected from homes and skin test reactivity. Conclusion: Asthma prevalence is similar in rural and urban children in Southwest Nigeria and atopy with elevated IgE was not observed to be a major factor for asthma in our cohort of children in both communities.

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Atopy Is Associated with Asthma in Adults Living in Rural and Urban Southwestern Nigeria

Abstract: Atopy is associated with adult asthma in southwest Nigeria. Larger studies to confirm the nature of this association and to examine the role of helminthic infection and other environmental factors on the expression of asthma are needed.

Cited by 5 publications

References 40 publications

Low prevalence of asthma in sub Saharan Africa: A cross sectional community survey in a suburban Nigerian town

Low prevalence of asthma in sub Saharan Africa: A cross sectional community survey in a suburban Nigerian town

Parasites and allergy: Observations from Africa

Allergy sensitization and asthma among 13-14 year old school children in Nigeria

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