Atopy in HIV-infected children attending the pediatric antiretroviral clinic of LAUTECH Teaching Hospital, Osogbo

Oyedeji, OA; Aa, Afolabi; Odeyemi, A. O.; Kayode, VO; Agelebe, Efeturi

doi:10.4103/njcp.njcp_359_19

Cited by 3 publications

(5 citation statements)

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“…[30] Allergic conjunctivitis was the predominant atopic disease among both infected and noninfected groups but the prevalence was higher among the infected. Though the prevalence was within the range reported in previous studies, [13,31] It was lower than what Martin-Odoom et al [32] reported in Ghana. The difference may be due to the fact that many of the participants in the Ghanaian study were of older ages.…”

Section: Discussionsupporting

confidence: 57%

“…This was not a surprise because clinical manifestations of atopic diseases have been documented in individuals with HIV infection. [9,13] A possible disequilibrium in the Th1-Th2 cytokines with Th2 taking pre-eminence suggests a predilection for atopic diseases in these patients. [26] Th2 cytokines play important roles in the pathogenesis of Funso Abidemi Olagunju et.al.…”

Section: Discussionmentioning

confidence: 99%

“…[12] Similarly increased prevalence of atopic diseases in HIV-infected patients had also been documented. [9,13] However, in Nigeria, there still exists a paucity of data on the serum IgE levels and the prevalence of atopic diseases in HIVinfected children compared to their noninfected counterparts. Also and to the best of the authors' knowledge, only one study in Nigeria assessed the association between the levels of serum immunoglobulin classes except for IgE levels and the severity of HIV infection in children in terms of Cluster of differentiation (CD) 4+ T-lymphocyte count.…”

Section: Introductionmentioning

confidence: 99%

“…[14] In addition, only one study also assessed the association between the prevalence of atopic diseases and the severity of HIV infection in terms of World Health Organization (WHO) HIV clinical staging. [13] Therefore, this study assessed the serum IgE levels, prevalence, and pattern of atopic diseases in HIV-infected and non-infected children aged 1-16 years at a Nigerian tertiary hospital. Also, the association between the severity of HIV infection and the serum IgE levels and the prevalence of atopic diseases was assessed in terms of WHO HIV clinical staging, CD 4+ count, and HIV viral load.…”

Section: Introductionmentioning

confidence: 99%

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Serum Immunoglobulin E levels and Atopic Diseases in Human Immunodeficiency Virus-Infected and Non-Infected Children and Their Association with the Severity of HIV Infection at a Tertiary Hospital, South-West Nigeria

Olagunju

Oninla

Oyedeji

2022

Int J Health Sci Res

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Human immunodeficiency virus (HIV) infection had been reported to increase serum Immunoglobulin E (IgE) and the prevalence of atopic diseases. However, there is a paucity of data in the literature on the association between the severity of HIV infection and serum IgE and atopic diseases among children in the Sub-Sahara African region, particularly Nigeria. OBJECTIVES: To assess serum IgE levels, prevalence and pattern of atopic diseases, and their association with the severity of HIV infection in children on antiretroviral therapy. METHODS: One hundred HIV-infected children on antiretroviral therapy recruited consecutively into a cross-sectional study were age and sex-matched with 100 non-infected. International study of asthma and allergy in childhood (ISAAC) proforma was used to obtain information from all the participants. Serum IgE levels and Cluster of differentiation (CD) 4+ counts of all the participants were determined, as well as, HIV viral load of the infected participants. HIV viral load, CD 4 counts and WHO clinical staging were used to classified HIV severity. Data analysis was done using statistical package for social sciences (SPSS) version 21, and statistic significant level was put at p<0.05. RESULTS: Mean (SD) serum IgE of the HIV-infected and non HIV-infected children were 150.6 (12.7)iμ/ml and 94.8 (5.6)iμ/ml respectively (p=0.001). The overall prevalence of atopic diseases among HIV-infected and non-infected children were 15.0% and 6.0% respectively, p=0.031. Among HIV-infected, allergic conjunctivitis accounted for 11.0% and allergic rhinitis 4.0%, while among non-infected allergic conjunctivitis, atopic dermatitis and asthma accounted for 4.0%, 1.0% and 1.0% respectively. Based on WHO clinical staging, serum IgE level was significantly higher in advanced disease than in early (p<0.001), and likewise the prevalence of atopic diseases (p=0.011).Funso Abidemi Olagunju et.al. Serum immunoglobulin E levels and atopic diseases in human immunodeficiency virus-infected and non-infected children and their association with the severity of HIV infection at a tertiary hospital, south-west Nigeria

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum Immunoglobulin E levels and Atopic Diseases in Human Immunodeficiency Virus-Infected and Non-Infected Children and Their Association with the Severity of HIV Infection at a Tertiary Hospital, South-West Nigeria

Olagunju

Oninla

Oyedeji

2022

Int J Health Sci Res

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“…Kritzinger et al found a strong association between severely immunocompromised HIV patients and VKC-like disease (chi-square = 4.992, P value = 0.0255) [46]. Studies suggest an association between allergic conjunctivitis and HIV positivity in adult patients in Ghana and Kenya, and in HIV-positive children in Nigeria [47–49]. Whether these were cases of VKC or not, was not stated in the reports.…”

Section: Factors Associated To Vernal Keratoconjunctivitis In Sub-sah...mentioning

confidence: 99%

Prevalence and clinical characteristics of vernal keratoconjunctivitis in sub-Saharan Africa

Nche

Okwen

Solomon

2023

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Vernal keratoconjunctivitis (VKC) is a chronic bilateral allergic inflammatory disease of the conjunctiva and cornea that affects children and young adults, especially in sub-Saharan Africa. A limbal form (tropical endemic limbo conjunctivitis) is thought to be more common in the tropics where research on this vision-impairing condition is scanty. We sought to review current literature from sub-Saharan Africa, with a focus on the prevalence of VKC and its clinical presentation. Recent findings There is a variable prevalence of VKC in SSA, up to 32.9% of children, especially in male individuals less than 5 years old, and has been diagnosed in a 4-month-old baby. Associated factors include exposure to dust, personal and family history of atopy, Vitamin D3 deficiency and HIV. The mixed form of VKC is the most frequent form seen and conjunctival pigmentation might be an early diagnostic sign. Summary Childhood screening programs for VKC should be established to reduce the morbidity, decreased quality of life and school absenteeism that is seen in these patients. VKC-related research should be encouraged in this milieu to bring to light the particularities of VKC in SSA.

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Vernal Keratoconjunctivitis as the Only Clinical Manifestation of HIV Infection

Farias

Gama

Mendes

et al. 2021

Ocular Immunology and Inflammation

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Atopy in HIV-infected children attending the pediatric antiretroviral clinic of LAUTECH Teaching Hospital, Osogbo

Cited by 3 publications

References 2 publications

Serum Immunoglobulin E levels and Atopic Diseases in Human Immunodeficiency Virus-Infected and Non-Infected Children and Their Association with the Severity of HIV Infection at a Tertiary Hospital, South-West Nigeria

Serum Immunoglobulin E levels and Atopic Diseases in Human Immunodeficiency Virus-Infected and Non-Infected Children and Their Association with the Severity of HIV Infection at a Tertiary Hospital, South-West Nigeria

Prevalence and clinical characteristics of vernal keratoconjunctivitis in sub-Saharan Africa

Vernal Keratoconjunctivitis as the Only Clinical Manifestation of HIV Infection

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