Atopy in children and parental social class.

Heinrich, Joachim; M, Popescu; Wjst, Matthias; Goldstein, Inge F.; Wichmann, H‐Erich

doi:10.2105/ajph.88.9.1319

Cited by 97 publications

(68 citation statements)

References 29 publications

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“…The association between socioeconomic status and asthma in children is complex [18] and is likely to depend on asthma severity, poverty, many lifestyle factors and potentially also country of residence. While (probably severe) asthma prevalence is higher in children from less privileged families in inner cities, we previously found that asthma is more prevalent in the higher social classes in a large cohort of German children, which is consistent with other German studies [19]. The impact of atopy on asthma remains unclear.…”

Section: Discussionsupporting

confidence: 89%

Prediction of new-onset asthma and nasal allergy by skin prick test and RAST in a cohort of adults

Gallmeier

Becker

Kirsten

et al. 2013

European Respiratory Journal

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Limited information exists regarding the incidence and predictors of asthma and nasal allergy in adulthood. We determined the incidence rate of asthma and nasal allergy in adults and assessed the predictive value of skin prick tests (SPTs) and radioallergosorbent tests (RASTs) for these two outcomes.Two German centres involved in the European Community Respiratory Health Survey conducted a follow-up assessment in 2012 of the baseline participants (1185 adults aged 21-47 years assessed in 1990). The predictive value of SPTs and RASTs on new-onset asthma and nasal allergy was assessed by Cox regression and by calculating the positive or negative predictive value.During the 20 years between baseline and follow-up, 3.1 and 4.4 per 1000 person-years of new-onset asthma and nasal allergy cases were recorded, respectively. The hazard ratios for SPTs of any specific and of all aeroallergens combined were slightly higher than those of RASTs for asthma and nasal allergy. The negative predictive values of both the SPT and RAST were very high and similar (0.94-0.96), whereas the postive predictive values were low (0.09-0.20).Positive SPT results showed a better association with new onset asthma and nasal allergy than positive RAST either to any specific aeroallergens or to all combined. @ERSpublications Positive SPT shows better association with new-onset asthma and nasal allergy than positive radioallergosorbent tests

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Section: Discussionsupporting

confidence: 89%

Prediction of new-onset asthma and nasal allergy by skin prick test and RAST in a cohort of adults

Gallmeier

Becker

Kirsten

et al. 2013

European Respiratory Journal

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“…This picture would seem to suggest that within communities, socioeconomic status is associated with asthma symptoms, but between communities with different lifestyles, asthma symptom prevalence is higher in affluent areas. This latter picture is consistent with the hygiene hypothesis and the picture of asthma prevalence in Europe [13,22,23].…”

Section: The Influence Of Socioeconomic Factorssupporting

confidence: 90%

Prevalence and socioeconomic associations of asthma and allergic rhinitis in nothern Africa

Georgy

Fahim²,

Gaafary³

et al. 2006

European Respiratory Journal

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The aims of the current study were to ascertain the prevalence of asthma and allergic rhinoconjunctivitis symptoms in Cairo, Egypt (nothern Africa), and to elucidate the socioeconomic factors associated with symptom prevalence and severity.A translated and adapted version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was distributed to a sample of 2,645 11-15-yr-olds in state and fee-paying schools in Cairo.The overall prevalences of wheeze ever, wheeze during the last year and physician-diagnosed asthma were 26.5% (697 out of 2,631), 14.7% (379 out of 2,570) and 9.4% (246 out of 2,609), respectively. The prevalence of rhinoconjunctivitis was 15.3% (399 out of 2,616). Asthma symptoms were independently associated with attendance at a state school, parental asthma, age, history of rhinitis and owning a pet cat. Rhinoconjunctivitis was independently associated with attendance at a state school, father's education, parental history of asthma, asthma symptoms and owning a pet cat. In spite of a higher prevalence of severe asthma symptoms in state schools prevalence of physician diagnosis of asthma was the same in both school types, suggesting inequalities in access to healthcare.In conclusion, the prevalence of physician-diagnosed asthma in Cairo was 9.4%, while the prevalence of rhinoconjunctivitis was 15.3%. There is a higher prevalence and increased severity of asthma symptoms in children of lower socioeconomic groups, as defined by state school attendance in Cairo.

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“…The use of animal skin might be a lifestyle factor, which is difficult to assess more specifically. Since we observed more common use of animal skin in more educated families and since asthma is more common in better-educated families in Germany [41], the reported protective effect of sleeping on animal skin on asthma is not likely to be confounded by social factors.…”

Section: Discussionmentioning

confidence: 59%

Sleeping on animal fur is related to asthma outcomes in later childhood

et al. 2015

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Animal furs might represent a "proxy" for high and diverse microbial exposures within a critical time window of immune development. We assessed whether sleeping on animal fur shortly after birth is associated with asthma and atopy up to the age of 10 years.LISAplus participants (n=2441) from Munich and Leipzig, Germany, were included in the analysis. Animal fur exposure, cofactors and health outcomes were obtained periodically up to 10 years of age by parental questionnaires. Information on specific IgE to aeroallergens was available at 10 years. Cytokineproducing peripheral T-cells were assessed in a subgroup of children at 2 and 3 years. Confounderadjusted associations were evaluated using logistic regression analyses.Sleeping on animal fur was very common (55%). In adjusted logistic regression analyses, sleeping on animal fur was inversely associated with recurrent early wheezing at 4 years (adjusted OR 0.75, 95% CI 0.61-0.93) and current asthma at 6 years (adjusted OR 0.56, 95% CI 0.31-1.01). Furthermore, sleeping on animal fur during the first 3 months of life was significantly associated with a persistently stimulated interferon-γ response until the age of 3 years.Animal fur could be an effective measure of creating environments associated with higher microbial exposure. @ERSpublications Use of animal fur could be effective for creating environments associated with possibly higher microbial exposure http://ow.ly/IWhTp

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Atopy in children and parental social class.

Cited by 97 publications

References 29 publications

Prediction of new-onset asthma and nasal allergy by skin prick test and RAST in a cohort of adults

Prediction of new-onset asthma and nasal allergy by skin prick test and RAST in a cohort of adults

Prevalence and socioeconomic associations of asthma and allergic rhinitis in nothern Africa

Sleeping on animal fur is related to asthma outcomes in later childhood

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