Atopic respiratory diseases and IgE sensitization are associated with leukocyte subset concentrations in 14,440 blood donors

Mikkelsen, Susan; Boldsen, Jens Kjærgaard; Møller, Bjarne Kuno; Dinh, Khoa Manh; Rostgaard, Klaus; Petersen, Mikkel Steen; Kaspersen, Kathrine Agergård; Pedersen, Ole Birger; Thørner, Lise Wegner; Handgaard, Linda Jenny; Ostrowski, Sisse Rye; Sigsgaard, Torben; Erikstrup, Christian

doi:10.1016/j.cca.2021.06.015

Cited by 2 publications

(2 citation statements)

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“…A recent study showed a clear association between specific IgE sensitization and an increase eosinophil concentration in an adult Danish population. 48 However, more studies are needed to understand the exact mechanism on the impact of blood eosinophilia and SPT positivity.…”

Section: Discussionmentioning

confidence: 99%

Aero-Allergen Sensitization in the General Population: Longitudinal Analyses of the LEAD (Lung Heart Social Body) Study

Kölli¹,

Breyer

Hartl³

et al. 2022

JAA

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Background: Monitoring of sensitization may become a non-invasive marker of impaired epithelial barrier function related to changing environmental conditions. Objective: To longitudinally evaluate the prevalence and associated factors for positive skin prick tests (SPT) in a general population cohort. Methods: Baseline and 4-year follow-up data from the longitudinal LEAD study are used for the current analyses. Risk factors for SPT were analyzed by multivariate binary logistic regression analyses, including residence (urban/rural), sex, socioeconomic status (SES), allergic and/or respiratory diseases, lung function testing, blood eosinophils, body composition, lifestyle habits, family history, pets in household, and exposure to tobacco smoke in childhood/adolescence (6-18 years) and adulthood (≥19 years). Results: In total, 1439 children/adolescents and 9844 adults with valid SPTs were included in these analyses. The prevalence of sensitization at baseline was 37.6% and was higher in males in every age group, except 10-<15 years. Individuals with doctor´s diagnosed allergy, asthma or parental allergy were more likely to have a positive SPT; in adulthood, sensitization was more common in those with a high SES. A lower occurrence of sensitization was associated with the presence of a dog in the household in childhood/ adolescence and with smoking in adulthood. The prevalence and intensity (number of positive SPT reactions) increased after a 4-year follow-up, especially in children/adolescents. Conclusion: Sensitization is common in the general Austrian population and more likely in males than females. Longitudinal monitoring of sensitization in children/adolescents may identify environmental triggers related to changes in urbanization, industrialization and domestic lifestyle. ClinicalTrials.gov NCT01727518.

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Section: Discussionmentioning

confidence: 99%

Aero-Allergen Sensitization in the General Population: Longitudinal Analyses of the LEAD (Lung Heart Social Body) Study

Kölli¹,

Breyer

Hartl³

et al. 2022

JAA

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several biomarkers have been measured in baseline and sequential plasma samples ( Table 2 ). 7 , 10 , 11 , 13–15 , 18 , 19 Additionally, the measurement of 54 immunological biomarkers using a V-PLEX Human Biomarker 54-Plex Kit (MesoScale) in 10 006 donors was recently finalized. Furthermore, genetic markers were assessed in a large fraction of the donors, counting 100 177 participants by February 2022 and growing.…”

Section: What Has Been Measured?mentioning

confidence: 99%