Atopic manifestations in the acquired immune deficiency syndrome: response to recombinant interferon gamma.

Parkin, Jacqueline; Eales, L J; Galazka, Andrew; Pinching, A J

doi:10.1136/bmj.294.6581.1185

Cited by 83 publications

(17 citation statements)

References 3 publications

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“…Of note, AIDS is also characterized by a high incidence of drug reactions and other clinical manifestations that resemble IgE-mediated hypersensitivity reactions (25)(26)(27). Elevated levels of IgE have been reported in patients with AIDS, either with or without a previous history of atopy (27).…”

Section: Resultsmentioning

confidence: 99%

Formation of IgE-binding factors by T cells of patients infected with human immunodeficiency virus type 1.

Carini

Margolick

Yodoi

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

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Peripheral blood mononuclear cells of 10 out of 26 patients with human immunodeficiency virus type 1 (HIV-1) released IgE-binding factors, as determined by two independent assays. The formation of the factors by the mononudear cells was enhanced by incubation of the cells with homologous IgE. In the presence of IgE, peripheral blood mononuclear cells from 15 of the 26 patients formed a detectable amount of IgE-binding factors, whereas those of normal individuals or allergic rhinitis patients failed to do so. The major source of IgE-binding factors was the T cells of the HIV-1-infected patients. The CD8 + T cells from a HIV-1-infected patient formed IgE-binding factors upon incubation with IgE, and type II receptors for FcE were detected on both CD4' T cells and CD8' T cells in one of five patients studied.It was also found that culture supernatants of mononuclear cells from HIV-1-infected patients released soluble factors that induce normal human T cells to form IgE-binding factors. The results suggest that lymphocytes of some HIV-1-infected patients are activated to produce lymphokines regulating formation of IgE-binding factors.Previous experiments have shown that peripheral blood mononuclear cells (PBMCs) from ragweed-sensitive allergic individuals released soluble factors having affinity for IgE when the cells were incubated with allergen together with human IgE (1). Activation of normal PBMCs with phytohemagglutinin followed by incubation of the activated T cells with IgE also induced the formation of IgE-binding factors (IgE-BF). Young et al. (2) established FcE receptor-positive (FcR+) human T-cell clones from a patient with atopic dermatitis and found that these clones released IgE-BF.

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Section: Resultsmentioning

confidence: 99%

Formation of IgE-binding factors by T cells of patients infected with human immunodeficiency virus type 1.

Carini

Margolick

Yodoi

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

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“…[17,27] In infants, the disorder may take the form of severe erythema and scaling of the face, scalp, and diaper area, sometimes progressing to erythroderma. [28,36] Atopic dermatitis: Parkin et al [53] documented the association of atopic manifestations with established AIDS. Atopic dermatitis appears to be triggered by HIV sero-conversion in genetically predisposed individuals.…”

Section: Inflammatory Dermatoses Pruritic Papular Eruption (Ppe): Ppementioning

confidence: 98%

Mucocutaneous manifestations in children with human immunodeficiency virus infection

Mendiratta¹,

Mittal²,

Jain³

et al. 2010

Indian J Dermatol Venereol Leprol

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Skin is one of the most frequently involved organs in human immunodeficiency virus (HIV) infection, and mucocutaneous manifestations may be one of the earliest markers of AIDS. The prevalence of cutaneous abnormalities in HIV approaches nearly 90%. Mucocutaneous manifestations may also act as a prognostic marker of HIV infection. Children are increasingly being affected by HIV infection and it is important to realize the presence of the infection early in the disease process as their immune status is not mature enough to handle the stress of various infections. Skin manifestations can serve as early markers and prognostic indicators of HIV infection. This review highlights the epidemiology, transmission, pathogenesis, and the mucocutaneous manifestations of HIV infection in children.

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“…Recent studies have indicated that helper factors released by activated T lymphocytes play a major role in the regulation of IgE secretion [19], 1L-4 is a T-cell-derived lymphokine that strikingly enhances the secretion of IgG 1 and IgE and stimulates mast cell growth. Moreover, it has been suggested that the induction of Fc(;Ri /CD23 on B cells seems to be specific for 1L-4 [16]. Recent work from several laboratories has shown that murine helper/inducer T-cell clones are composed of at least two nonoverlapping subsets that can be distinguished on the basis of their patterns of lymphokine secretion [8,15].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, our re sults suggest that reduced IFNy generation may con tribute to defective NK cell activity in AD. Interest ingly, patients with AD treated with recombinant IFNy showed a striking improvement in symptoms and cellular immunity [16]. Generation of IFNy was analyzed in vitro because serum IFNy concentration in controls is normally below detectable levels.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin E and Immunoglobulin G Subclass Distribution in vivo and Relationship to in vitro Generation of Interferon-Gamma and Neopterin in Patients with Severe Atopic Dermatitis

Reinhold¹,

Pawelec²,

Wehrmann

et al. 1988

Int Arch Allergy Immunol

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In vitro interferon-gamma (IFNγ) and neopterin generation by peripheral blood mononuclear cells (PBMC) from 15 patients with severe atopic dermatitis (AD) and 10 healthy controls was investigated. A significant proportion of patients had an impaired capacity to secrete IFNγ after phytohemagglutinin (PHA) stimulation in vitro and therefore IFNγ production was significantly lower compared to controls. Neopterin generation in vitro did not differ significantly from that of controls and no correlation between in vitro IFNγ and neopterin production could be observed in either group. Analysis of serum IgG subclass distribution showed that patients with AD had increased IgG4 serum concentrations while IgG1, IgG2 and IgG3 levels did not differ significantly from those of controls. Surface marker analysis revealed increased numbers of CD23⁺ lymphocytes in patients with AD which was positively correlated with the serum IgG4 and IgE concentration. Furthermore, a significant correlation was found between IFNγ generation in vitro and IgE and IgG4 concentration in vivo in AD. The data suggest that a possible dysregulation of IFNγ, interleukin-4 or other lymphokine production may be related to increased IgE and IgG4 production and seems to be an important factor in the pathogenesis of AD.

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Atopic manifestations in the acquired immune deficiency syndrome: response to recombinant interferon gamma.

Cited by 83 publications

References 3 publications

Formation of IgE-binding factors by T cells of patients infected with human immunodeficiency virus type 1.

Formation of IgE-binding factors by T cells of patients infected with human immunodeficiency virus type 1.

Mucocutaneous manifestations in children with human immunodeficiency virus infection

Immunoglobulin E and Immunoglobulin G Subclass Distribution in vivo and Relationship to in vitro Generation of Interferon-Gamma and Neopterin in Patients with Severe Atopic Dermatitis

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